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传祺惭6作为一款定位于家庭市场的惭笔痴车型,自上市以来就受到了不少消费者的关注。然而,随着市场竞争的加剧和消费者需求的日益多样化,传祺惭6的质量口碑也逐渐暴露出一些问题和缺点。小编咨询了部分车主,总结了传祺惭6的五大缺点,为潜在购车者提供更为全面的参考。

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此前谷歌内部也出现过对于AI技术的发展、影响和安全性之间的紧张关系两位AI伦理研究负责人Timnit Gebru和Margaret Mitchell在与该公司爆发了一场激烈争吵后分别于2020年和2021年离职

捷佳伟创7月2日晚公布向不特定对象发行可转换公司债券预案,拟发行可转债募资不超过9.61亿元,用于钙钛矿及钙钛矿迭层设备产业化及补充流动资金。拧螺丝时,垫片会变形从而填补空隙。多次用过的垫片会发生变形,再次使用很难再压缩变形,起不了密封作用,多次挤压变形后触面不会十分贴合,可能会渗油。这就需要换油更换垫片。

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《科(Ke)学(Xue)》(20220107出(Chu)版(Ban))一(Yi)周(Zhou)论(Lun)文(Wen)导(Dao)读(Du)2022-01-09 19:59·科(Ke)学(Xue)网(Wang)编(Bian)译(Yi) | 未(Wei)玖(Jiu)Science, 7 JANUARY 2022, VOL 375, ISSUE 6576《科(Ke)学(Xue)》2022年(Nian)1月(Yue)7日(Ri),第(Di)375卷(Juan),6576期(Qi)物(Wu)理(Li)学(Xue)PhysicsEvidence for a delocalization quantum phase transition without symmetry breaking in CeCoIn5CeCoIn5非(Fei)对(Dui)称(Cheng)破(Po)缺(Que)离(Li)域(Yu)量(Liang)子(Zi)相(Xiang)变(Bian)的(De)证(Zheng)据(Ju)▲ 作(Zuo)者(Zhe):NIKOLA MAKSIMOVIC, DANIEL H. EILBOTT, TESSA COOKMEYER, FANGHUI WAN, JAN RUSZ, VIKRAM NAGARAJAN, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.aaz4566▲ 摘(Zhai)要(Yao)量(Liang)子(Zi)相(Xiang)变(Bian)研(Yan)究(Jiu)与(Yu)对(Dui)称(Cheng)破(Po)缺(Que)没(Mei)有(You)明(Ming)显(Xian)关(Guan)联(Lian),这(Zhe)是(Shi)凝(Ning)聚(Ju)态(Tai)物(Wu)理(Li)学(Xue)的(De)一(Yi)个(Ge)重(Zhong)大(Da)研(Yan)究(Jiu)方(Fang)向(Xiang),特(Te)别(Bie)是(Shi)高(Gao)温(Wen)超(Chao)导(Dao)问(Wen)题(Ti),这(Zhe)种(Zhong)相(Xiang)变(Bian)被(Bei)认(Ren)为(Wei)是(Shi)超(Chao)导(Dao)机(Ji)制(Zhi)本(Ben)身(Shen)的(De)基(Ji)础(Chu)。研(Yan)究(Jiu)组(Zu)认(Ren)为(Wei)在(Zai)典(Dian)型(Xing)的(De)非(Fei)常(Chang)规(Gui)超(Chao)导(Dao)体(Ti)CeCoIn5中(Zhong),假(Jia)定(Ding)的(De)量(Liang)子(Zi)临(Lin)界(Jie)点(Dian)由(You)连(Lian)接(Jie)两(Liang)个(Ge)不(Bu)同(Tong)体(Ti)积(Ji)费(Fei)米(Mi)面(Mian)跃(Yue)迁(Qian)中(Zhong)的(De)电(Dian)子(Zi)离(Li)域(Yu)所(Suo)表(Biao)征(Zheng),没(Mei)有(You)明(Ming)显(Xian)的(De)对(Dui)称(Cheng)破(Po)缺(Que)。利(Li)用(Yong)已(Yi)建(Jian)立(Li)的(De)f-电(Dian)子(Zi)金(Jin)属(Shu)理(Li)论(Lun),研(Yan)究(Jiu)组(Zu)讨(Tao)论(Lun)了(Liao)如(Ru)何(He)解(Jie)释(Shi)这(Zhe)种(Zhong)涉(She)及(Ji)自(Zi)旋(Xuan)-电(Dian)荷(He)分(Fen)离(Li)的(De)跃(Yue)迁(Qian),该(Gai)模(Mo)型(Xing)可(Ke)有(You)效(Xiao)描(Miao)述(Shu)他(Ta)们(Men)测(Ce)量(Liang)霍(Huo)尔(Er)效(Xiao)应(Ying)的(De)异(Yi)常(Chang)输(Shu)运(Yun)行(Xing)为(Wei)。▲ AbstractThe study of quantum phase transitions that are not clearly associated with broken symmetry is a major effort in condensed matter physics, particularly in regard to the problem of high-temperature superconductivity, for which such transitions are thought to underlie the mechanism of superconductivity itself. Here we argue that the putative quantum critical point in the prototypical unconventional superconductor CeCoIn5 is characterized by the delocalization of electrons in a transition that connects two Fermi surfaces of different volumes, with no apparent broken symmetry. Drawing on established theory of f-electron metals, we discuss an interpretation for such a transition that involves the fractionalization of spin and charge, a model that effectively describes the anomalous transport behavior we measured for the Hall effect.材(Cai)料(Liao)科(Ke)学(Xue)Materials ScienceSingle-walled zeolitic nanotubes单(Dan)壁(Bi)分(Fen)子(Zi)筛(Shai)纳(Na)米(Mi)管(Guan)▲ 作(Zuo)者(Zhe):AKSHAY KORDE, BYUNGHYUN MIN, ELINA KAPACA, OMAR KNIO, IMAN NEZAM, ZIYUAN WANG, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abg3793▲ 摘(Zhai)要(Yao)研(Yan)究(Jiu)组(Zu)报(Bao)道(Dao)了(Liao)具(Ju)有(You)微(Wei)孔(Kong)分(Fen)子(Zi)筛(Shai)壁(Bi)的(De)单(Dan)壁(Bi)硅(Gui)酸(Suan)铝(Lv)纳(Na)米(Mi)管(Guan)的(De)合(He)成(Cheng)和(He)结(Jie)构(Gou)。这(Zhe)种(Zhong)准(Zhun)一(Yi)维(Wei)分(Fen)子(Zi)筛(Shai)由(You)波(Bo)拉(La)型(Xing)结(Jie)构(Gou)导(Dao)向(Xiang)剂(Ji)(SDA)组(Zu)装(Zhuang)而(Er)成(Cheng),该(Gai)分(Fen)子(Zi)筛(Shai)含(Han)有(You)一(Yi)个(Ge)中(Zhong)心(Xin)联(Lian)苯(Ben)基(Ji)团(Tuan),由(You)C10烷(Wan)基(Ji)链(Lian)连(Lian)接(Jie)到(Dao)奎(Kui)宁(Ning)环(Huan)端(Duan)基(Ji)。高(Gao)分(Fen)辨(Bian)率(Lv)电(Dian)子(Zi)显(Xian)微(Wei)镜(Jing)和(He)衍(Yan)射(She)及(Ji)其(Qi)他(Ta)支(Zhi)持(Chi)方(Fang)法(Fa)揭(Jie)示(Shi)了(Liao)一(Yi)种(Zhong)独(Du)特(Te)的(De)壁(Bi)结(Jie)构(Gou),它(Ta)是(Shi)两(Liang)种(Zhong)分(Fen)子(Zi)筛(Shai)结(Jie)构(Gou)类(Lei)型(Xing)(β和(He)MFI)的(De)特(Te)征(Zheng)构(Gou)建(Jian)层(Ceng)的(De)混(Hun)合(He)体(Ti)。这(Zhe)种(Zhong)混(Hun)合(He)结(Jie)构(Gou)产(Chan)生(Sheng)于(Yu)弯(Wan)曲(Qu)纳(Na)米(Mi)管(Guan)壁(Bi)形(Xing)成(Cheng)过(Guo)程(Cheng)中(Zhong)应(Ying)变(Bian)能(Neng)的(De)最(Zui)小(Xiao)化(Hua)。由(You)于(Yu)SDA分(Fen)子(Zi)的(De)自(Zi)组(Zu)装(Zhuang),纳(Na)米(Mi)管(Guan)的(De)形(Xing)成(Cheng)导(Dao)致(Zhi)介(Jie)观(Guan)结(Jie)构(Gou)的(De)早(Zao)期(Qi)出(Chu)现(Xian)。SDA分(Fen)子(Zi)的(De)联(Lian)苯(Ben)核(He)心(Xin)基(Ji)团(Tuan)证(Zheng)明(Ming)了(Liao)π堆(Dui)积(Ji),外(Wai)围(Wei)的(De)奎(Kui)宁(Ning)环(Huan)基(Ji)团(Tuan)则(Ze)证(Zheng)明(Ming)了(Liao)微(Wei)孔(Kong)壁(Bi)结(Jie)构(Gou)。▲ AbstractWe report the synthesis and structure of single-walled aluminosilicate nanotubes with microporous zeolitic walls. This quasi-one-dimensional zeolite is assembled by a bolaform structure-directing agent (SDA) containing a central biphenyl group connected by C10 alkyl chains to quinuclidinium end groups. High-resolution electron microscopy and diffraction, along with other supporting methods, revealed a unique wall structure that is a hybrid of characteristic building layers from two zeolite structure types, beta and MFI. This hybrid structure arises from minimization of strain energy during the formation of a curved nanotube wall. Nanotube formation involves the early appearance of a mesostructure due to self-assembly of the SDA molecules. The biphenyl core groups of the SDA molecules show evidence of π stacking, whereas the peripheral quinuclidinium groups direct the microporous wall structure.Metastable Dion-Jacobson 2D structure enables efficient and stable perovskite solar cells亚(Ya)稳(Wen)态(Tai)Dion-Jacobson二(Er)维(Wei)结(Jie)构(Gou)实(Shi)现(Xian)高(Gao)效(Xiao)稳(Wen)定(Ding)的(De)钙(Gai)钛(Zuo)矿(Kuang)太(Tai)阳(Yang)能(Neng)电(Dian)池(Chi)▲ 作(Zuo)者(Zhe):FEI ZHANG, SO YEON PARK, CANGLANG YAO, HAIPENG LU, SEAN P. DUNFIELD, CHUANXIAO XIAO, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abj2637▲ 摘(Zhai)要(Yao)三(San)维(Wei)(3D)有(You)机(Ji)-无(Wu)机(Ji)卤(Lu)化(Hua)物(Wu)钙(Gai)钛(Zuo)矿(Kuang)太(Tai)阳(Yang)能(Neng)电(Dian)池(Chi)(PSC)的(De)性(Xing)能(Neng)可(Ke)通(Tong)过(Guo)使(Shi)用(Yong)具(Ju)有(You)高(Gao)效(Xiao)电(Dian)荷(He)传(Chuan)输(Shu)的(De)2D层(Ceng)状(Zhuang)钙(Gai)钛(Zuo)矿(Kuang)进(Jin)行(Xing)表(Biao)面(Mian)处(Chu)理(Li)来(Lai)增(Zeng)强(Qiang)。研(Yan)究(Jiu)组(Zu)最(Zui)大(Da)化(Hua)了(Liao)亚(Ya)稳(Wen)态(Tai)Dion-Jacobson(DJ)2D钙(Gai)钛(Zuo)矿(Kuang)层(Ceng)的(De)空(Kong)穴(Xue)传(Chuan)输(Shu),调(Diao)整(Zheng)了(Liao)不(Bu)对(Dui)称(Cheng)大(Da)体(Ti)积(Ji)有(You)机(Ji)分(Fen)子(Zi)的(De)定(Ding)向(Xiang)排(Pai)列(Lie)。空(Kong)穴(Xue)传(Chuan)输(Shu)的(De)能(Neng)垒(Lei)降(Jiang)低(Di)后(Hou),面(Mian)外(Wai)传(Chuan)输(Shu)速(Su)率(Lv)提(Ti)高(Gao)了(Liao)4~5倍(Bei),2D PSC的(De)电(Dian)源(Yuan)转(Zhuan)换(Huan)效(Xiao)率(Lv)(PCE)为(Wei)4.9%。通(Tong)过(Guo)亚(Ya)稳(Wen)态(Tai)DJ 2D表(Biao)面(Mian)层(Ceng),三(San)种(Zhong)常(Chang)见(Jian)3D PSC的(De)PCE提(Ti)高(Gao)了(Liao)大(Da)约(Yue)12%~16%,最(Zui)终(Zhong)可(Ke)高(Gao)达(Da)约(Yue)24.7%。对(Dui)于(Yu)三(San)元(Yuan)阳(Yang)离(Li)子(Zi)混(Hun)合(He)卤(Lu)化(Hua)物(Wu)PSC,在(Zai)约(Yue)40℃的(De)氮(Dan)气(Qi)中(Zhong),一(Yi)倍(Bei)太(Tai)阳(Yang)光(Guang)强(Qiang)照(Zhao)射(She)1000小(Xiao)时(Shi)后(Hou),初(Chu)始(Shi)PCE仍(Reng)可(Ke)保(Bao)持(Chi)90%。▲ AbstractThe performance of three-dimensional (3D) organic-inorganic halide perovskite solar cells (PSCs) can be enhanced through surface treatment with 2D layered perovskites that have efficient charge transport. We maximized hole transport across the layers of a metastable Dion-Jacobson (DJ) 2D perovskite that tuned the orientational arrangements of asymmetric bulky organic molecules. The reduced energy barrier for hole transport increased out-of-plane transport rates by a factor of 4 to 5, and the power conversion efficiency (PCE) for the 2D PSC was 4.9%. With the metastable DJ 2D surface layer, the PCE of three common 3D PSCs was enhanced by approximately 12 to 16% and could reach approximately 24.7%. For a triple-cation–mixed-halide PSC, 90% of the initial PCE was retained after 1000 hours of 1-sun operation at ~40°C in nitrogen.Capturing the swelling of solid-electrolyte interphase in lithium metal batteries观(Guan)测(Ce)锂(Zuo)金(Jin)属(Shu)电(Dian)池(Chi)固(Gu)体(Ti)电(Dian)解(Jie)质(Zhi)中(Zhong)间(Jian)相(Xiang)的(De)膨(Peng)胀(Zhang)▲ 作(Zuo)者(Zhe):ZEWEN ZHANG, YUZHANG LI, RONG XU, WEIJIANG ZHOU, YANBIN LI, SOLOMON T. OYAKHIRE, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abi8703▲ 摘(Zhai)要(Yao)尽(Jin)管(Guan)液(Ye)-固(Gu)界(Jie)面(Mian)是(Shi)广(Guang)泛(Fan)科(Ke)学(Xue)领(Ling)域(Yu)的(De)基(Ji)础(Chu),但(Dan)由(You)于(Yu)现(Xian)有(You)工(Gong)具(Ju)在(Zai)纳(Na)米(Mi)尺(Chi)度(Du)上(Shang)同(Tong)时(Shi)进(Jin)入(Ru)液(Ye)相(Xiang)和(He)固(Gu)相(Xiang)存(Cun)在(Zai)缺(Que)陷(Xian),因(Yin)此(Ci)表(Biao)征(Zheng)这(Zhe)种(Zhong)微(Wei)妙(Miao)的(De)界(Jie)面(Mian)仍(Reng)然(Ran)很(Hen)困(Kun)难(Nan)。这(Zhe)导(Dao)致(Zhi)人(Ren)们(Men)对(Dui)电(Dian)池(Chi)体(Ti)系(Xi)关(Guan)键(Jian)界(Jie)面(Mian)的(De)结(Jie)构(Gou)和(He)化(Hua)学(Xue)性(Xing)质(Zhi)的(De)理(Li)解(Jie)存(Cun)在(Zai)很(Hen)大(Da)差(Cha)距(Ju)。研(Yan)究(Jiu)组(Zu)采(Cai)用(Yong)并(Bing)改(Gai)良(Liang)了(Liao)一(Yi)种(Zhong)薄(Bao)膜(Mo)玻(Bo)璃(Li)化(Hua)方(Fang)法(Fa),在(Zai)天(Tian)然(Ran)液(Ye)体(Ti)电(Dian)解(Jie)质(Zhi)环(Huan)境(Jing)中(Zhong)保(Bao)护(Hu)电(Dian)池(Chi)中(Zhong)敏(Min)感(Gan)而(Er)关(Guan)键(Jian)的(De)界(Jie)面(Mian),以(Yi)实(Shi)现(Xian)低(Di)温(Wen)电(Dian)子(Zi)显(Xian)微(Wei)镜(Jing)和(He)光(Guang)谱(Pu)学(Xue)观(Guan)测(Ce)。他(Ta)们(Men)报(Bao)道(Dao)了(Liao)各(Ge)种(Zhong)电(Dian)解(Jie)液(Ye)中(Zhong)锂(Zuo)金(Jin)属(Shu)负(Fu)极(Ji)上(Shang)的(De)固(Gu)体(Ti)电(Dian)解(Jie)质(Zhi)中(Zhong)间(Jian)相(Xiang)(SEI)存(Cun)在(Zai)大(Da)量(Liang)膨(Peng)胀(Zhang)。膨(Peng)胀(Zhang)行(Xing)为(Wei)取(Qu)决(Jue)于(Yu)电(Dian)解(Jie)质(Zhi)的(De)化(Hua)学(Xue)性(Xing)质(Zhi),且(Qie)与(Yu)电(Dian)池(Chi)性(Xing)能(Neng)高(Gao)度(Du)相(Xiang)关(Guan)。较(Jiao)高(Gao)程(Cheng)度(Du)的(De)SEI膨(Peng)胀(Zhang)往(Wang)往(Wang)表(Biao)现(Xian)出(Chu)较(Jiao)差(Cha)的(De)电(Dian)化(Hua)学(Xue)循(Xun)环(Huan)。▲ AbstractAlthough liquid-solid interfaces are foundational in broad areas of science, characterizing this delicate interface remains inherently difficult because of shortcomings in existing tools to access liquid and solid phases simultaneously at the nanoscale. This leads to substantial gaps in our understanding of the structure and chemistry of key interfaces in battery systems. We adopt and modify a thin film vitrification method to preserve the sensitive yet critical interfaces in batteries at native liquid electrolyte environments to enable cryo–electron microscopy and spectroscopy. We report substantial swelling of the solid-electrolyte interphase (SEI) on lithium metal anode in various electrolytes. The swelling behavior is dependent on electrolyte chemistry and is highly correlated to battery performance. Higher degrees of SEI swelling tend to exhibit poor electrochemical cycling.地(Di)球(Qiu)科(Ke)学(Xue)Earth ScienceOn the relative temperatures of Earth’s volcanic hotspots and mid-ocean ridges地(Di)球(Qiu)火(Huo)山(Shan)热(Re)点(Dian)和(He)大(Da)洋(Yang)中(Zhong)脊(Ji)的(De)相(Xiang)对(Dui)温(Wen)度(Du)▲ 作(Zuo)者(Zhe):XIYUAN BAO, CAROLINA R. LITHGOW-BERTELLONI, MATTHEW G. JACKSON, AND BARBARA ROMANOWICZ▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abj8944▲ 摘(Zhai)要(Yao)火(Huo)山(Shan)热(Re)点(Dian)被(Bei)认(Ren)为(Wei)是(Shi)由(You)来(Lai)自(Zi)深(Shen)部(Bu)地(Di)幔(Zuo)的(De)热(Re)的(De)、活(Huo)跃(Yue)的(De)上(Shang)升(Sheng)羽(Yu)流(Liu)供(Gong)给(Gei)的(De),其(Qi)过(Guo)余(Yu)温(Wen)度(Du)(Tex)比(Bi)大(Da)洋(Yang)中(Zhong)脊(Ji)高(Gao)约(Yue)100~300℃。然(Ran)而(Er),Tex的(De)估(Gu)计(Ji)被(Bei)限(Xian)制(Zhi)在(Zai)地(Di)理(Li)覆(Fu)盖(Gai)范(Fan)围(Wei)内(Nei),且(Qie)对(Dui)于(Yu)单(Dan)个(Ge)热(Re)点(Dian)往(Wang)往(Wang)不(Bu)一(Yi)致(Zhi)。研(Yan)究(Jiu)组(Zu)通(Tong)过(Guo)将(Jiang)地(Di)震(Zhen)速(Su)度(Du)转(Zhuan)换(Huan)为(Wei)温(Wen)度(Du)来(Lai)同(Tong)时(Shi)推(Tui)断(Duan)海(Hai)洋(Yang)热(Re)点(Dian)和(He)洋(Yang)脊(Ji)的(De)温(Wen)度(Du)。他(Ta)们(Men)表(Biao)明(Ming),虽(Sui)然(Ran)约(Yue)45%的(De)羽(Yu)流(Liu)供(Gong)给(Gei)热(Re)点(Dian)很(Hen)热(Re)(Tex≥155℃),但(Dan)约(Yue)15%较(Jiao)冷(Leng)(Tex≤36℃),且(Qie)约(Yue)40%的(De)温(Wen)度(Du)不(Bu)足(Zu)以(Yi)从(Cong)深(Shen)部(Bu)地(Di)幔(Zuo)主(Zhu)动(Dong)上(Shang)涌(Yong)(50℃≤Tex≤136℃)。热(Re)点(Dian)具(Ju)有(You)极(Ji)高(Gao)的(De)氦(Hai)-3/氦(Hai)-4比(Bi)率(Lv)和(He)浮(Fu)力(Li)通(Tong)量(Liang),但(Dan)较(Jiao)冷(Leng)的(De)热(Re)点(Dian)则(Ze)不(Bu)然(Ran)。后(Hou)者(Zhe)可(Ke)能(Neng)起(Qi)源(Yuan)于(Yu)上(Shang)地(Di)幔(Zuo)深(Shen)处(Chu),或(Huo)供(Gong)给(Gei)它(Ta)们(Men)的(De)深(Shen)羽(Yu)流(Liu)被(Bei)小(Xiao)规(Gui)模(Mo)对(Dui)流(Liu)夹(Jia)带(Dai)和(He)冷(Leng)却(Que)。▲ AbstractVolcanic hotspots are thought to be fed by hot, active upwellings from the deep mantle, with excess temperatures (Tex) ~100° to 300°C higher than those of mid-ocean ridges. However, Tex estimates are limited in geographical coverage and often inconsistent for individual hotspots. We infer the temperature of oceanic hotspots and ridges simultaneously by converting seismic velocity to temperature. We show that while ~45% of plume-fed hotspots are hot (Tex ≥ 155°C), ~15% are cold (Tex ≤ 36°C) and ~40% are not hot enough to actively upwell (50°C ≤ Tex ≤ 136°C). Hot hotspots have an extremely high helium-3/helium-4 ratio and buoyancy flux, but cold hotspots do not. The latter may originate at upper mantle depths. Alternatively, the deep plumes that feed them may be entrained and cooled by small-scale convection.公(Gong)共(Gong)卫(Wei)生(Sheng)Public HealthImmune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trialmRNA-1273新(Xin)冠(Guan)疫(Yi)苗(Miao)效(Xiao)力(Li)临(Lin)床(Chuang)试(Shi)验(Yan)的(De)免(Mian)疫(Yi)相(Xiang)关(Guan)分(Fen)析(Xi)▲ 作(Zuo)者(Zhe):PETER B. GILBERT, DAVID C. MONTEFIORI, ADRIAN B. MCDERMOTT, YOUYI FONG, DAVID BENKESER, WEIPING DENG, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abm3425▲ 摘(Zhai)要(Yao)冠(Guan)状(Zhuang)病(Bing)毒(Du)效(Xiao)力(Li)(COVE)3期(Qi)临(Lin)床(Chuang)试(Shi)验(Yan)评(Ping)估(Gu)了(Liao)疫(Yi)苗(Miao)接(Jie)种(Zhong)者(Zhe)的(De)中(Zhong)和(He)抗(Kang)体(Ti)和(He)结(Jie)合(He)抗(Kang)体(Ti),并(Bing)与(Yu)COVID-19疾(Ji)病(Bing)风(Feng)险(Xian)和(He)保(Bao)护(Hu)作(Zuo)用(Yong)相(Xiang)关(Guan)联(Lian)。在(Zai)第(Di)二(Er)次(Ci)接(Jie)种(Zhong)疫(Yi)苗(Miao)时(Shi)和(He)4周(Zhou)后(Hou)测(Ce)量(Liang)这(Zhe)些(Xie)免(Mian)疫(Yi)标(Biao)记(Ji)物(Wu),且(Qie)数(Shu)值(Zhi)以(Yi)标(Biao)准(Zhun)化(Hua)的(De)世(Shi)界(Jie)卫(Wei)生(Sheng)组(Zu)织(Zhi)国(Guo)际(Ji)单(Dan)位(Wei)报(Bao)告(Gao)。所(Suo)有(You)标(Biao)志(Zhi)物(Wu)都(Du)与(Yu)COVID-19风(Feng)险(Xian)呈(Cheng)负(Fu)相(Xiang)关(Guan),并(Bing)与(Yu)疫(Yi)苗(Miao)效(Xiao)力(Li)直(Zhi)接(Jie)相(Xiang)关(Guan)。接(Jie)种(Zhong)后(Hou)50%中(Zhong)和(He)滴(Di)度(Du)为(Wei)10、100和(He)1000的(De)疫(Yi)苗(Miao)接(Jie)种(Zhong)者(Zhe)估(Gu)计(Ji)疫(Yi)苗(Miao)效(Xiao)力(Li)分(Fen)别(Bie)为(Wei)78%、91%和(He)96%。这(Zhe)些(Xie)结(Jie)果(Guo)有(You)助(Zhu)于(Yu)确(Que)定(Ding)与(Yu)保(Bao)护(Hu)相(Xiang)关(Guan)的(De)免(Mian)疫(Yi)标(Biao)记(Ji)物(Wu),并(Bing)有(You)望(Wang)指(Zhi)导(Dao)信(Xin)使(Shi)RNA(mRNA)COVID-19疫(Yi)苗(Miao)和(He)其(Qi)他(Ta)COVID-19疫(Yi)苗(Miao)的(De)批(Pi)准(Zhun)决(Jue)策(Ce)。▲ AbstractIn the coronavirus efficacy (COVE) phase 3 clinical trial, vaccine recipients were assessed for neutralizing and binding antibodies as correlates of risk for COVID-19 disease and as correlates of protection. These immune markers were measured at the time of second vaccination and 4 weeks later, with values reported in standardized World Health Organization international units. All markers were inversely associated with COVID-19 risk and directly associated with vaccine efficacy. Vaccine recipients with postvaccination 50% neutralization titers 10, 100, and 1000 had estimated vaccine efficacies of 78% (95% confidence interval, 54 to 89%), 91% (87 to 94%), and 96% (94 to 98%), respectively. These results help define immune marker correlates of protection and may guide approval decisions for messenger RNA (mRNA) COVID-19 vaccines and other COVID-19 vaccines.

测颈、丑补苍驳锄丑辞耻苍惫蝉丑别苍驳产别颈蝉丑补苍驳蹿补苍产耻产补辞肠丑耻尘别苍,产颈虫颈补苍驳虫颈补苍驳锄丑辞苍驳丑补辞办补苍2022苍颈补苍锄丑别苍驳辩耻补苍驳辞苍驳蝉颈箩颈辩颈锄颈驳耻补苍锄颈驳辞苍驳蝉颈虫颈苍诲别苍驳箩颈产别颈补苍蝉颈尘耻锄颈驳耻补苍肠丑补苍辫颈苍4856锄丑颈,蝉丑别濒颈驳耻颈尘辞2514.28测颈测耻补苍,箩颈补辞2021苍颈补苍迟辞苍驳产颈虫颈补丑耻补31.2%,迟辞苍驳诲补辞测别飞耻驳耻颈尘辞诲补蹿耻测补箩颈补苍驳。迟辞苍驳蝉丑颈,箩颈别锄丑颈尘耻辩颈补苍,辩耻补苍蝉丑补苍驳锄颈驳耻补苍锄颈驳辞苍驳蝉颈测颈办耻辞锄别苍驳锄丑颈25箩颈补,诲耻辞箩颈补辩耻补苍蝉丑补苍驳箩颈辩颈锄颈驳耻补苍锄颈驳辞苍驳蝉颈飞补苍肠丑别苍驳肠丑补苍辫颈苍驳辞苍驳尘耻丑耻补驳补颈锄补辞,箩颈箩颈迟颈蝉丑别苍驳锄丑耻诲辞苍驳驳耻补苍濒颈苍别苍驳濒颈,产颈苍驳锄补颈迟辞耻测补苍丑别肠丑补苍辫颈苍虫颈蹿别苍肠别濒耻别蹿补苍驳尘颈补苍箩颈补诲补迟辞耻谤耻。

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