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浩(Hao)如(Ru)繁(Fan)星(Xing)的(De)人(Ren)类(Lei)肿(Zhong)瘤(Liu)威(Wei)胁(Xie)?WHO的(De)肿(Zhong)瘤(Liu)分(Fen)类(Lei)2020-06-24 21:22·制(Zhi)药(Yao)学(Xue)砖(Zhuan)家(Jia)相(Xiang)声(Sheng)里(Li)说(Shuo),人(Ren)纵(Zong)是(Shi)浑(Hun)身(Shen)是(Shi)铁(Tie),又(You)能(Neng)钉(Ding)几(Ji)根(Gen)钉(Ding)子(Zi)?何(He)曾(Zeng)想(Xiang)到(Dao),这(Zhe)样(Yang)一(Yi)个(Ge)躯(Qu)壳(Ke)内(Nei),在(Zai)滚(Gun)滚(Gun)而(Er)来(Lai)的(De)时(Shi)代(Dai)发(Fa)展(Zhan)浪(Lang)潮(Chao)中(Zhong),竟(Jing)然(Ran)会(Hui)面(Mian)对(Dui)数(Shu)不(Bu)胜(Sheng)数(Shu)的(De)肿(Zhong)瘤(Liu)类(Lei)型(Xing)的(De)侵(Qin)害(Hai)。起(Qi)始(Shi)于(Yu)19世(Shi)纪(Ji)60-70年(Nian)代(Dai),世(Shi)界(Jie)卫(Wei)生(Sheng)组(Zu)织(Zhi)(WHO)为(Wei)了(Liao)便(Bian)于(Yu)肿(Zhong)瘤(Liu)临(Lin)床(Chuang)诊(Zhen)疗(Liao)和(He)临(Lin)床(Chuang)研(Yan)究(Jiu),尽(Jin)其(Qi)所(Suo)能(Neng)地(Di)汇(Hui)编(Bian)了(Liao)人(Ren)类(Lei)迄(Qi)今(Jin)为(Wei)止(Zhi)遇(Yu)到(Dao)的(De)所(Suo)有(You)肿(Zhong)瘤(Liu)类(Lei)型(Xing)。主(Zhu)流(Liu)的(De)肿(Zhong)瘤(Liu)编(Bian)码(Ma)规(Gui)则(Ze)分(Fen)部(Bu)位(Wei)编(Bian)码(Ma)和(He)形(Xing)态(Tai)学(Xue)编(Bian)码(Ma)两(Liang)种(Zhong),WHO沿(Yan)用(Yong)了(Liao)形(Xing)态(Tai)学(Xue)编(Bian)码(Ma),来(Lai)源(Yuan)于(Yu)国(Guo)际(Ji)疾(Ji)病(Bing)分(Fen)类(Lei)(ICD-O)(898A)。作(Zuo)这(Zhe)样(Yang)选(Xuan)择(Ze)概(Gai)因(Yin)肿(Zhong)瘤(Liu)是(Shi)机(Ji)体(Ti)内(Nei)细(Xi)胞(Bao)在(Zai)内(Nei)部(Bu)和(He)外(Wai)界(Jie)致(Zhi)癌(Ai)因(Yin)素(Su)长(Chang)期(Qi)作(Zuo)用(Yong)下(Xia)诱(You)发(Fa),并(Bing)且(Qie)演(Yan)化(Hua)发(Fa)展(Zhan)的(De)生(Sheng)长(Chang)物(Wu),形(Xing)态(Tai)学(Xue)编(Bian)码(Ma)不(Bu)仅(Jin)区(Qu)分(Fen)了(Liao)肿(Zhong)瘤(Liu)的(De)大(Da)致(Zhi)发(Fa)病(Bing)部(Bu)位(Wei),还(Huan)能(Neng)够(Gou)准(Zhun)确(Que)锁(Suo)定(Ding)其(Qi)发(Fa)展(Zhan)阶(Jie)段(Duan),为(Wei)临(Lin)床(Chuang)诊(Zhen)疗(Liao)和(He)研(Yan)究(Jiu)提(Ti)供(Gong)了(Liao)便(Bian)利(Li)。WHO的(De)肿(Zhong)瘤(Liu)分(Fen)类(Lei)目(Mu)录(Lu)也(Ye)一(Yi)直(Zhi)与(Yu)时(Shi)俱(Ju)进(Jin),并(Bing)积(Ji)极(Ji)采(Cai)纳(Na)肺(Fei)腺(Xian)癌(Ai)国(Guo)际(Ji)肺(Fei)癌(Ai)研(Yan)究(Jiu)协(Xie)会(Hui)/美(Mei)国(Guo)胸(Xiong)科(Ke)学(Xue)会(Hui)/欧(Ou)洲(Zhou)呼(Hu)吸(Xi)学(Xue)会(Hui)(IASLC/ATS/ERS)国(Guo)际(Ji)多(Duo)学(Xue)科(Ke)分(Fen)类(Lei)方(Fang)法(Fa)来(Lai)自(Zi)我(Wo)完(Wan)善(Shan)。肿(Zhong)瘤(Liu)类(Lei)型(Xing)一(Yi)级(Ji)分(Fen)类(Lei)多(Duo)达(Da)11类(Lei),包(Bao)括(Kuo)淋(Lin)巴(Ba)造(Zao)血(Xue)、内(Nei)分(Fen)泌(Mi)、肺(Fei)与(Yu)纵(Zong)膈(Zuo)、乳(Ru)腺(Xian)、消(Xiao)化(Hua)系(Xi)统(Tong)、泌(Mi)尿(Niao)和(He)男(Nan)性(Xing)生(Sheng)殖(Zhi) 、女(Nv)性(Xing)生(Sheng)殖(Zhi)、头(Tou)颈(Jing)、中(Zhong)枢(Shu)神(Shen)经(Jing)、皮(Pi)肤(Fu)、骨(Gu)及(Ji)软(Ruan)组(Zu)织(Zhi)。二(Er)级(Ji)分(Fen)类(Lei)为(Wei)35类(Lei),其(Qi)中(Zhong)消(Xiao)化(Hua)系(Xi)统(Tong)和(He)头(Tou)颈(Jing)一(Yi)级(Ji)分(Fen)类(Lei)下(Xia)的(De)二(Er)级(Ji)分(Fen)类(Lei)最(Zui)多(Duo),均(Jun)为(Wei)8种(Zhong)。试(Shi)看(Kan)《2015年(Nian)版(Ban)WHO胸(Xiong)腺(Xian)及(Ji)纵(Zong)膈(Zuo)肿(Zhong)瘤(Liu)分(Fen)类(Lei)》一(Yi)种(Zhong),其(Qi)下(Xia)分(Fen)上(Shang)皮(Pi)性(Xing)肿(Zhong)瘤(Liu)、混(Hun)合(He)性(Xing)胸(Xiong)腺(Xian)癌(Ai)、髓(Sui)系(Xi)肉(Rou)瘤(Liu)和(He)髓(Sui)外(Wai)急(Ji)性(Xing)髓(Sui)系(Xi)白(Bai)血(Xue)病(Bing)4种(Zhong),再(Zai)往(Wang)下(Xia)还(Huan)分(Fen)出(Chu)8小(Xiao)类(Lei)。胸(Xiong)腺(Xian)及(Ji)纵(Zong)膈(Zuo)肿(Zhong)瘤(Liu)分(Fen)类(Lei)下(Xia)对(Dui)应(Ying)到(Dao)具(Ju)体(Ti)肿(Zhong)瘤(Liu)共(Gong)计(Ji)有(You)82种(Zhong),由(You)此(Ci)反(Fan)观(Guan)整(Zheng)个(Ge)肿(Zhong)瘤(Liu)族(Zu)谱(Pu),种(Zhong)类(Lei)总(Zong)数(Shu)量(Liang)可(Ke)见(Jian)一(Yi)斑(Ban)。在(Zai)如(Ru)此(Ci)众(Zhong)多(Duo)的(De)肿(Zhong)瘤(Liu)疾(Ji)病(Bing)中(Zhong),人(Ren)们(Men)也(Ye)是(Shi)作(Zuo)着(Zhuo)不(Bu)屈(Qu)不(Bu)挠(Nao)的(De)抗(Kang)争(Zheng)。不(Bu)计(Ji)其(Qi)数(Shu)的(De)药(Yao)物(Wu)被(Bei)开(Kai)发(Fa)出(Chu)来(Lai),或(Huo)者(Zhe)正(Zheng)在(Zai)研(Yan)制(Zhi)的(De)途(Tu)中(Zhong),比(Bi)如(Ru)已(Yi)上(Shang)市(Shi)的(De)国(Guo)内(Nei)首(Shou)个(Ge)自(Zi)主(Zhu)创(Chuang)新(Xin)药(Yao)盐(Yan)酸(Suan)埃(Ai)克(Ke)替(Ti)尼(Ni),用(Yong)于(Yu)治(Zhi)疗(Liao)非(Fei)小(Xiao)细(Xi)胞(Bao)肺(Fei)癌(Ai)(NSCLC)的(De);ALK抑(Yi)制(Zhi)剂(Ji)盐(Yan)酸(Suan)恩(En)沙(Sha)替(Ti)尼(Ni)正(Zheng)在(Zai)研(Yan)究(Jiu)开(Kai)发(Fa)中(Zhong),能(Neng)够(Gou)治(Zhi)疗(Liao)ALK阳(Yang)性(Xing)非(Fei)小(Xiao)细(Xi)胞(Bao)肺(Fei)癌(Ai)。虽(Sui)千(Qian)万(Wan)里(Li),吾(Wu)往(Wang)矣(Yi)。人(Ren)类(Lei)对(Dui)抗(Kang)肿(Zhong)瘤(Liu)的(De)历(Li)程(Cheng)也(Ye)注(Zhu)定(Ding)是(Shi)可(Ke)歌(Ge)可(Ke)泣(Qi)的(De)不(Bu)朽(Xiu)历(Li)史(Shi)。
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最(窜耻颈)后(贬辞耻)拐(骋耻补颈)一(驰颈)句(闯耻),驴(尝惫)子(窜颈)在(窜补颈)西(齿颈)方(贵补苍驳)文(奥别苍)化(贬耻补)中(窜丑辞苍驳)象(齿颈补苍驳)征(窜丑别苍驳)什(厂丑颈)么(惭别),与(驰耻)在(窜补颈)中(窜丑辞苍驳)国(骋耻辞)有(驰辞耻)不(叠耻)少(厂丑补辞)相(齿颈补苍驳)似(厂颈)之(窜丑颈)处(颁丑耻),毕(叠颈)竟(闯颈苍驳)驴(尝惫)不(叠耻)如(搁耻)马(惭补)强(蚕颈补苍驳)壮(窜丑耻补苍驳)迅(齿耻苍)捷(闯颈别)却(蚕耻别)比(叠颈)马(惭补)便(叠颈补苍)宜(驰颈),这(窜丑别)在(窜补颈)欧(翱耻)亚(驰补)大(顿补)陆(尝耻)的(顿别)东(顿辞苍驳)端(顿耻补苍)或(贬耻辞)西(齿颈)端(顿耻补苍),并(叠颈苍驳)不(叠耻)会(贬耻颈)有(驰辞耻)什(厂丑颈)么(惭别)区(蚕耻)别(叠颈别)。基(闯颈)督(顿耻)教(闯颈补辞)起(蚕颈)先(齿颈补苍)是(厂丑颈)穷(蚕颈辞苍驳)人(搁别苍)的(顿别)宗(窜辞苍驳)教(闯颈补辞),所(厂耻辞)以(驰颈)耶(驰别)稣(窜耻辞)去(蚕耻)耶(驰别)路(尝耻)撒(厂补)冷(尝别苍驳),骑(蚕颈)的(顿别)自(窜颈)然(搁补苍)是(厂丑颈)驴(尝惫)。驴(尝惫)子(窜颈)既(闯颈)被(叠别颈)当(顿补苍驳)作(窜耻辞)蠢(颁丑耻苍)笨(叠别苍)的(顿别)代(顿补颈)表(叠颈补辞),又(驰辞耻)仿(贵补苍驳)佛(贵辞)有(驰辞耻)某(惭辞耻)种(窜丑辞苍驳)智(窜丑颈)慧(贬耻颈)的(顿别)神(厂丑别苍)性(齿颈苍驳)。正(窜丑别苍驳)如(搁耻)中(窜丑辞苍驳)国(骋耻辞)文(奥别苍)化(贬耻补)人(搁别苍)和(贬别)驴(尝惫)子(窜颈)在(窜补颈)一(驰颈)起(蚕颈),构(骋辞耻)成(颁丑别苍驳)一(驰颈)幅(贵耻)既(闯颈)寒(贬补苍)窘(闯颈辞苍驳)又(驰辞耻)孤(骋耻)高(骋补辞),既(闯颈)落(尝耻辞)寞(惭辞)又(驰辞耻)超(颁丑补辞)逸(驰颈)的(顿别)画(贬耻补)面(惭颈补苍),西(齿颈)方(贵补苍驳)的(顿别)文(奥别苍)艺(驰颈)作(窜耻辞)品(笔颈苍)中(窜丑辞苍驳),也(驰别)常(颁丑补苍驳)有(驰辞耻)驴(尝惫)背(叠别颈)上(厂丑补苍驳)的(顿别)智(窜丑颈)者(窜丑别),或(贬耻辞)者(窜丑别)如(搁耻)《动(顿辞苍驳)物(奥耻)农(狈辞苍驳)庄(窜丑耻补苍驳)》里(尝颈),象(齿颈补苍驳)征(窜丑别苍驳)知(窜丑颈)识(厂丑颈)分(贵别苍)子(窜颈)的(顿别),干(骋补苍)脆(颁耻颈)就(闯颈耻)是(厂丑颈)一(驰颈)头(罢辞耻)驴(尝惫)。
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