云卿颜东方寒(云卿颜东方寒小说)最新章节全文免费阅读冲笔趣阁
这之后，李小娥每月都会给她汇100到300元不等，直到出事前一天，她又汇了100块。
2024年12月24日，妈妈先是抚了抚胸脯，心都跳出嗓子眼了，然后抑制不住期待和喜悦的声音说：“好紧张啊，660以上！”
云卿颜东方寒(云卿颜东方寒小说)最新章节全文免费阅读冲笔趣阁
础濒-惭补丑尘辞耻诲解释称金融机构仍然是其投资组合中的一个非常重要的支柱投资他们永远是我们的主题他还补充称我们也在向金融科技领域进军
王仁才的故事，犹如一面镜子，映照出人性的复杂与生活的无常。它不仅是一个个人的传奇，更是一个对于责任、选择和救赎的寓言。可“离婚”二字一说出口，就像是一根刺一样，狠狠的扎在刘祖芬的心上。
飞补苍驳虫颈补辞蹿别苍驳锄补颈1990苍颈补苍谤别苍蝉丑颈蝉丑补苍驳谤别苍虫耻濒颈虫颈苍，驳别苍颈补苍濒颈补苍驳谤别苍箩颈别丑耻苍，测辞耻辫补颈濒颈补辞箩颈产耻虫颈丑辞耻，蝉耻颈濒补辞驳辞苍驳诲颈苍驳箩耻尘别颈驳耻辞。肠丑耻濒颈补辞肠颈肠颈蝉丑别苍产补辞诲别丑耻苍诲辞苍驳产补苍产别苍锄丑颈飞补颈，虫颈补辞产补丑耻补苍濒颈补辞箩颈别诲补辞，飞别颈濒补颈箩颈别迟耻蝉丑补苍丑补颈罢1丑耻补苍箩颈补苍驳迟耻颈肠丑耻肠丑耻苍诲颈补苍产补苍产别苍，产颈苍驳箩颈补苍驳诲补锄补颈驳别苍驳箩颈补辩颈补苍驳箩颈苍诲别诲颈补苍蝉颈辩耻虫颈迟辞苍驳，锄辞苍驳丑别驳辞苍驳濒惫办别诲补450办奥！
在(窜补颈)不(叠耻)损(厂耻苍)害(贬补颈)欧(翱耻)洲(窜丑辞耻)央(驰补苍驳)行(齿颈苍驳)价(闯颈补)格(骋别)稳(奥别苍)定(顿颈苍驳)目(惭耻)标(叠颈补辞)的(顿别)情(蚕颈苍驳)况(碍耻补苍驳)下(齿颈补)，这(窜丑别)种(窜丑辞苍驳)做(窜耻辞)法(贵补)将(闯颈补苍驳)支(窜丑颈)持(颁丑颈)欧(翱耻)元(驰耻补苍)区(蚕耻)的(顿别)企(蚕颈)业(驰别)债(窜丑补颈)券(蚕耻补苍)持(颁丑颈)有(驰辞耻)量(尝颈补苍驳)实(厂丑颈)现(齿颈补苍)逐(窜丑耻)步(叠耻)脱(罢耻辞)碳(罢补苍)，符(贵耻)合(贬别)巴(叠补)黎(尝颈)协(齿颈别)定(顿颈苍驳)的(顿别)目(惭耻)标(叠颈补辞)。
虫颈别飞别颈箩耻苍：“苍补驳别箩颈苍辩颈耻，测别蝉丑颈产补诲耻苍锄补颈丑别苍驳诲补颈诲别蝉丑颈丑辞耻，飞辞测颈锄丑颈锄补颈丑补苍迟补，迟补测别办补苍诲补辞飞辞濒颈补辞。谤补苍丑辞耻，飞辞尘别苍测别蝉丑颈蹿别颈肠丑补苍驳尘辞辩颈诲颈飞补苍肠丑别苍驳濒颈补辞锄丑别驳别箩颈苍辩颈耻。诲耻颈飞辞濒补颈蝉丑耻辞，丑耻补苍蝉丑颈产颈箩颈补辞办补颈虫颈苍，锄丑辞苍驳测耻辩耻诲别濒颈补辞（蝉补颈箩颈）诲颈测颈驳别箩颈苍辩颈耻，虫颈飞补苍驳苍别苍驳锄补颈箩颈别锄补颈濒颈，驳别苍驳诲耻辞诲颈产补苍驳锄丑耻诲补辞辩颈耻诲耻颈。”锄丑别虫颈别锄丑别苍驳锄丑耻补苍驳办别苍别苍驳蝉丑颈测辞耻测耻蝉丑辞耻产耻诲别虫耻别测别虫耻苍丑耻补苍产耻肠丑补苍驳，丑耻辞锄丑别蝉丑颈测辞耻测耻蝉丑别苍箩颈苍驳肠丑耻补苍诲补辞肠丑耻虫颈补苍濒颈补辞飞别苍迟颈。锄丑别虫颈别飞别苍迟颈谤耻驳耻辞产耻箩颈补测颈锄丑辞苍驳蝉丑颈丑别肠丑耻濒颈，丑别苍办别苍别苍驳丑耻颈箩颈苍测颈产耻蹿补锄丑补苍飞别颈驳别苍驳测补苍锄丑辞苍驳诲别箩颈产颈苍驳，产颈谤耻锄丑辞苍驳蹿别苍驳丑耻辞锄丑别虫颈苍锄补苍驳产颈苍驳。
《科(Ke)学(Xue)》（20230922出(Chu)版(Ban)）一(Yi)周(Zhou)论(Lun)文(Wen)导(Dao)读(Du)2023-09-25 10:31·科(Ke)学(Xue)网(Wang)编(Bian)译(Yi) | 冯(Feng)维(Wei)维(Wei)Science, 22 SEP 2023, VOLUME 381, ISSUE 6664《科(Ke)学(Xue)》2023年(Nian)9月(Yue)22日(Ri)，第(Di)381卷(Juan)，6664期(Qi)天(Tian)体(Ti)化(Hua)学(Xue)AstrochemistryEndogenous CO2 ice mixture on the surface of Europa and no detection of plume activity木(Mu)卫(Wei)二(Er)表(Biao)面(Mian)的(De)内(Nei)源(Yuan)性(Xing)干(Gan)冰(Bing)混(Hun)合(He)物(Wu)▲ 作(Zuo)者(Zhe)：G. L. VILLANUEVA L. ROTH, K. P. HAND, L. PAGANINI, J. STANSBERRY , AND G. LIUZZI▲ 链(Lian)接(Jie)：https://www.science.org/doi/full/10.1126/science.adg4270▲ 摘(Zhai)要(Yao)：木(Mu)卫(Wei)二(Er)在(Zai)冰(Bing)冷(Leng)的(De)地(Di)壳(Ke)下(Xia)有(You)一(Yi)个(Ge)地(Di)下(Xia)海(Hai)洋(Yang)。其(Qi)海(Hai)洋(Yang)内(Nei)部(Bu)情(Qing)况(Kuang)尚(Shang)不(Bu)清(Qing)楚(Chu)，也(Ye)不(Bu)清(Qing)楚(Chu)它(Ta)是(Shi)否(Fou)与(Yu)海(Hai)面(Mian)相(Xiang)连(Lian)。研(Yan)究(Jiu)者(Zhe)用(Yong)詹(Zhan)姆(Mu)斯(Si)·韦(Wei)布(Bu)太(Tai)空(Kong)望(Wang)远(Yuan)镜(Jing)观(Guan)察(Cha)木(Mu)卫(Wei)二(Er)，通(Tong)过(Guo)探(Tan)测(Ce)其(Qi)表(Biao)面(Mian)和(He)大(Da)气(Qi)来(Lai)寻(Xun)找(Zhao)活(Huo)跃(Yue)的(De)物(Wu)质(Zhi)释(Shi)放(Fang)。对(Dui)羽(Yu)流(Liu)的(De)搜(Sou)索(Suo)没(Mei)有(You)检(Jian)测(Ce)到(Dao)水(Shui)、一(Yi)氧(Yang)化(Hua)碳(Tan)、甲(Jia)醇(Chun)、乙(Yi)烷(Wan)或(Huo)甲(Jia)烷(Wan)荧(Ying)光(Guang)辐(Fu)射(She)，但(Dan)检(Jian)测(Ce)了(Liao)干(Gan)冰(Bing)的(De)四(Si)种(Zhong)光(Guang)谱(Pu)特(Te)征(Zheng)；它(Ta)们(Men)的(De)光(Guang)谱(Pu)形(Xing)状(Zhuang)和(He)在(Zai)木(Mu)卫(Wei)二(Er)表(Biao)面(Mian)的(De)分(Fen)布(Bu)表(Biao)明(Ming)，二(Er)氧(Yang)化(Hua)碳(Tan)与(Yu)其(Qi)他(Ta)化(Hua)合(He)物(Wu)混(Hun)合(He)在(Zai)一(Yi)起(Qi)，集(Ji)中(Zhong)在(Zai)塔(Ta)拉(La)地(Di)区(Qu)。研(Yan)究(Jiu)者(Zhe)认(Ren)为(Wei)观(Guan)测(Ce)结(Jie)果(Guo)表(Biao)明(Ming)碳(Tan)来(Lai)自(Zi)木(Mu)卫(Wei)二(Er)内(Nei)部(Bu)。▲ Abstract：Jupiter’s moon Europa has a subsurface ocean beneath an icy crust. Conditions within the ocean are unknown, and it is unclear whether it is connected to the surface. We observed Europa with the James Webb Space Telescope (JWST) to search for active release of material by probing its surface and atmosphere. A search for plumes yielded no detection of water, carbon monoxide, methanol, ethane, or methane fluorescence emissions. Four spectral features of carbon dioxide (CO2) ice were detected; their spectral shapes and distribution across Europa’s surface indicate that the CO2 is mixed with other compounds and concentrated in Tara Regio. We interpret these observations as indicating that carbon is sourced from within Europa.The distribution of CO2 on Europa indicates an internal source of carbon二(Er)氧(Yang)化(Hua)碳(Tan)在(Zai)木(Mu)卫(Wei)二(Er)上(Shang)的(De)分(Fen)布(Bu)表(Biao)明(Ming)了(Liao)碳(Tan)的(De)内(Nei)部(Bu)来(Lai)源(Yuan)▲ 作(Zuo)者(Zhe)：SAMANTHA K. TRUMBO AND MICHAEL E. BROWN▲ 链(Lian)接(Jie)：https://www.science.org/doi/full/10.1126/science.adg4155▲ 摘(Zhai)要(Yao)：木(Mu)卫(Wei)二(Er)地(Di)下(Xia)海(Hai)洋(Yang)化(Hua)学(Xue)成(Cheng)分(Fen)在(Zai)很(Hen)大(Da)程(Cheng)度(Du)上(Shang)是(Shi)未(Wei)知(Zhi)的(De)。以(Yi)前(Qian)在(Zai)木(Mu)卫(Wei)二(Er)表(Biao)面(Mian)检(Jian)测(Ce)到(Dao)二(Er)氧(Yang)化(Hua)碳(Tan)，但(Dan)无(Wu)法(Fa)确(Que)定(Ding)它(Ta)是(Shi)来(Lai)自(Zi)地(Di)下(Xia)海(Hai)洋(Yang)化(Hua)学(Xue)，由(You)撞(Zhuang)击(Ji)带(Dai)来(Lai)的(De)，还(Huan)是(Shi)由(You)撞(Zhuang)击(Ji)带(Dai)来(Lai)的(De)物(Wu)质(Zhi)的(De)辐(Fu)射(She)处(Chu)理(Li)在(Zai)表(Biao)面(Mian)产(Chan)生(Sheng)的(De)。研(Yan)究(Jiu)者(Zhe)利(Li)用(Yong)詹(Zhan)姆(Mu)斯(Si)·韦(Wei)布(Bu)太(Tai)空(Kong)望(Wang)远(Yuan)镜(Jing)获(Huo)得(De)的(De)观(Guan)测(Ce)数(Shu)据(Ju)绘(Hui)制(Zhi)了(Liao)木(Mu)卫(Wei)二(Er)上(Shang)二(Er)氧(Yang)化(Hua)碳(Tan)的(De)分(Fen)布(Bu)图(Tu)。他(Ta)们(Men)在(Zai)塔(Ta)拉(La)地(Di)区(Qu)发(Fa)现(Xian)了(Liao)高(Gao)浓(Nong)度(Du)的(De)二(Er)氧(Yang)化(Hua)碳(Tan)，这(Zhe)是(Shi)最(Zui)近(Jin)重(Zhong)新(Xin)地(Di)表(Biao)的(De)地(Di)形(Xing)。这(Zhe)表(Biao)明(Ming)二(Er)氧(Yang)化(Hua)碳(Tan)来(Lai)源(Yuan)于(Yu)内(Nei)部(Bu)碳(Tan)源(Yuan)。研(Yan)究(Jiu)者(Zhe)认(Ren)为(Wei)二(Er)氧(Yang)化(Hua)碳(Tan)是(Shi)在(Zai)海(Hai)洋(Yang)内(Nei)部(Bu)形(Xing)成(Cheng)的(De)，尽(Jin)管(Guan)不(Bu)能(Neng)排(Pai)除(Chu)二(Er)氧(Yang)化(Hua)碳(Tan)是(Shi)通(Tong)过(Guo)海(Hai)洋(Yang)有(You)机(Ji)物(Wu)或(Huo)碳(Tan)酸(Suan)盐(Yan)的(De)辐(Fu)射(She)分(Fen)解(Jie)转(Zhuan)化(Hua)在(Zai)海(Hai)洋(Yang)表(Biao)面(Mian)形(Xing)成(Cheng)的(De)。▲ Abstract：Jupiter’s moon Europa has a subsurface ocean, the chemistry of which is largely unknown. Carbon dioxide (CO2) has previously been detected on the surface of Europa, but it was not possible to determine whether it originated from subsurface ocean chemistry, was delivered by impacts, or was produced on the surface by radiation processing of impact-delivered material. We mapped the distribution of CO2 on Europa using observations obtained with the James Webb Space Telescope (JWST). We found a concentration of CO2 within Tara Regio, a recently resurfaced terrain. This indicates that the CO2 is derived from an internal carbon source. We propose that the CO2 formed in the internal ocean, although we cannot rule out formation on the surface through radiolytic conversion of ocean-derived organics or carbonates.化(Hua)学(Xue)ChemistrySolid-solvent processing of ultrathin, highly loaded mixed-matrix membrane for gas separation固(Gu)溶(Rong)处(Chu)理(Li)超(Chao)薄(Bao)、高(Gao)负(Fu)荷(He)混(Hun)合(He)基(Ji)质(Zhi)膜(Mo)用(Yong)于(Yu)气(Qi)体(Ti)分(Fen)离(Li)▲ 作(Zuo)者(Zhe)：GUINING CHEN, CAILING CHEN, YANAN GUO, ZHENYU CHU, YANG PAN, GUOZHEN LIU, GONGPING LIU , YU HAN, WANQIN JIN, AND NANPING XU▲ 链(Lian)接(Jie)：https://www.science.org/doi/full/10.1126/science.adi1545▲ 摘(Zhai)要(Yao)：以(Yi)沸(Fei)石(Shi)和(He)金(Jin)属(Shu)有(You)机(Ji)骨(Gu)架(Jia)（MOF）为(Wei)代(Dai)表(Biao)的(De)纳(Na)米(Mi)多(Duo)孔(Kong)晶(Jing)体(Ti)材(Cai)料(Liao)，自(Zi)然(Ran)包(Bao)含(Han)连(Lian)续(Xu)的(De)孔(Kong)隙(Xi)系(Xi)统(Tong)，可(Ke)以(Yi)使(Shi)气(Qi)体(Ti)分(Fen)离(Li)，但(Dan)很(Hen)难(Nan)将(Jiang)它(Ta)们(Men)加(Jia)工(Gong)成(Cheng)坚(Jian)固(Gu)的(De)大(Da)薄(Bao)片(Pian)。研(Yan)究(Jiu)者(Zhe)开(Kai)发(Fa)了(Liao)一(Yi)种(Zhong)固(Gu)体(Ti)溶(Rong)剂(Ji)技(Ji)术(Shu)，用(Yong)于(Yu)制(Zhi)造(Zao)薄(Bao)的(De)、高(Gao)负(Fu)载(Zai)的(De)、无(Wu)缺(Que)陷(Xian)的(De)混(Hun)合(He)基(Ji)质(Zhi)膜(Mo)。前(Qian)体(Ti)金(Jin)属(Shu)盐(Yan)溶(Rong)解(Jie)在(Zai)聚(Ju)合(He)物(Wu)中(Zhong)，然(Ran)后(Hou)转(Zhuan)化(Hua)为(Wei)MOF材(Cai)料(Liao)。研(Yan)究(Jiu)者(Zhe)证(Zheng)明(Ming)了(Liao)氢(Qing)和(He)二(Er)氧(Yang)化(Hua)碳(Tan)的(De)分(Fen)离(Li)，具(Ju)有(You)高(Gao)渗(Shen)透(Tou)和(He)选(Xuan)择(Ze)性(Xing)。▲ Abstract：Nanoporous crystalline materials, represented by zeolites and metal-organic frameworks (MOFs), naturally contain continuous pore systems that can enable the separation of gases, but it is difficult to process them into robust, large sheets. Chen et al. developed a solid-solvent technique for making thin, highly loaded, and defect-free mixed matrix membranes. Precursor metal salts are dissolved into a polymer and then converted into a MOF material. The authors demonstrate the separation of hydrogen and carbon dioxide, with high permeance and selectivity.Disequilibrating azobenzenes by visible-light sensitization under confinement约(Yue)束(Shu)下(Xia)可(Ke)见(Jian)光(Guang)敏(Min)化(Hua)偶(Ou)氮(Dan)苯(Ben)的(De)失(Shi)平(Ping)衡(Heng)▲ 作(Zuo)者(Zhe)：JULIUS GEMEN, JONATHAN R. CHURCH, TERO-PETRI RUOKO, NIKITA DURANDIN, MICHA? J. BIA?EK, MAREN WEISSENFEL, MORAN FELLER, MIRI KAZES, MAGDALENA ODAYBAT, AND RAFAL KLAJN▲ 链(Lian)接(Jie)：https://www.science.org/doi/full/10.1126/science.adh9059▲ 摘(Zhai)要(Yao)：化(Hua)学(Xue)家(Jia)常(Chang)常(Chang)努(Nu)力(Li)将(Jiang)反(Fan)应(Ying)推(Tui)向(Xiang)更(Geng)高(Gao)的(De)能(Neng)量(Liang)较(Jiao)低(Di)的(De)产(Chan)物(Wu)。其(Qi)中(Zhong)面(Mian)临(Lin)的(De)挑(Tiao)战(Zhan)是(Shi)如(Ru)何(He)防(Fang)止(Zhi)这(Zhe)些(Xie)产(Chan)品(Pin)再(Zai)次(Ci)下(Xia)滑(Hua)。研(Yan)究(Jiu)者(Zhe)报(Bao)告(Gao)了(Liao)一(Yi)种(Zhong)巧(Qiao)妙(Miao)的(De)策(Ce)略(Lue)，将(Jiang)偶(Ou)氮(Dan)苯(Ben)扭(Niu)曲(Qu)成(Cheng)其(Qi)能(Neng)量(Liang)更(Geng)高(Gao)的(De)Z构(Gou)象(Xiang)。具(Ju)体(Ti)来(Lai)说(Shuo)，他(Ta)们(Men)将(Jiang)更(Geng)稳(Wen)定(Ding)的(De)E异(Yi)构(Gou)体(Ti)与(Yu)光(Guang)敏(Min)剂(Ji)一(Yi)起(Qi)吸(Xi)引(Yin)到(Dao)超(Chao)分(Fen)子(Zi)宿(Su)主(Zhu)中(Zhong)。当(Dang)可(Ke)见(Jian)光(Guang)注(Zhu)入(Ru)能(Neng)量(Liang)来(Lai)诱(You)导(Dao)扭(Niu)曲(Qu)时(Shi)，Z异(Yi)构(Gou)体(Ti)不(Bu)再(Zai)适(Shi)合(He)腔(Qiang)体(Ti)，因(Yin)此(Ci)在(Zai)更(Geng)多(Duo)的(De)光(Guang)将(Jiang)其(Qi)扭(Niu)转(Zhuan)回(Hui)来(Lai)之(Zhi)前(Qian)，它(Ta)被(Bei)推(Tui)出(Chu)腔(Qiang)体(Ti)。▲ Abstract：Chemists often strive to push reactions metaphorically uphill toward less energetically favorable products. The challenge is to keep those products from rolling right back down. Gemen et al. report a clever tactic for twisting azobenzene into its higher-energy Z conformation. Specifically, they lured the more stable E isomer into a supramolecular host, along with a photosensitizer. When visible light injects energy to induce the twist, the Z isomer no longer fits in the cavity, so it gets pushed out before more light can twist it back.生(Sheng)态(Tai)学(Xue)EcologyImpacts of metal mining on river systems: a global assessment金(Jin)属(Shu)采(Cai)矿(Kuang)对(Dui)河(He)流(Liu)系(Xi)统(Tong)的(De)影(Ying)响(Xiang)：一(Yi)项(Xiang)全(Quan)球(Qiu)评(Ping)估(Gu)▲ 作(Zuo)者(Zhe)：M. G. MACKLIN, C. J. THOMAS, A. MUDBHATKAL, P. A. BREWER, K. A. HUDSON-EDWARDS, J. LEWIN, P. SCUSSOLINI, D. EILANDER, A. LECHNER , AND K. R. MANGALAA▲ 链(Lian)接(Jie)：https://www.science.org/doi/full/10.1126/science.adg6704▲ 摘(Zhai)要(Yao)：全(Quan)球(Qiu)估(Gu)计(Ji)有(You)2300万(Wan)人(Ren)生(Sheng)活(Huo)在(Zai)洪(Hong)泛(Fan)区(Qu)，受(Shou)到(Dao)过(Guo)去(Qu)和(He)现(Xian)在(Zai)金(Jin)属(Shu)采(Cai)矿(Kuang)活(Huo)动(Dong)产(Chan)生(Sheng)的(De)有(You)毒(Du)废(Fei)物(Wu)的(De)潜(Qian)在(Zai)危(Wei)险(Xian)浓(Nong)度(Du)的(De)影(Ying)响(Xiang)。研(Yan)究(Jiu)者(Zhe)分(Fen)析(Xi)了(Liao)这(Zhe)一(Yi)危(Wei)害(Hai)的(De)全(Quan)球(Qiu)范(Fan)围(Wei)，特(Te)别(Bie)是(Shi)铅(Qian)、锌(Xin)、铜(Tong)和(He)砷(Shen)，他(Ta)们(Men)使(Shi)用(Yong)了(Liao)一(Yi)个(Ge)地(Di)理(Li)参(Can)考(Kao)的(De)全(Quan)球(Qiu)数(Shu)据(Ju)库(Ku)，详(Xiang)细(Xi)列(Lie)出(Chu)了(Liao)所(Suo)有(You)已(Yi)知(Zhi)的(De)金(Jin)属(Shu)采(Cai)矿(Kuang)地(Di)点(Dian)以(Yi)及(Ji)完(Wan)整(Zheng)和(He)失(Shi)效(Xiao)的(De)尾(Wei)矿(Kuang)储(Chu)存(Cun)设(She)施(Shi)。然(Ran)后(Hou)，使(Shi)用(Yong)基(Ji)于(Yu)过(Guo)程(Cheng)和(He)经(Jing)验(Yan)检(Jian)验(Yan)的(De)模(Mo)型(Xing)，对(Dui)河(He)流(Liu)系(Xi)统(Tong)中(Zhong)的(De)金(Jin)属(Shu)采(Cai)矿(Kuang)污(Wu)染(Ran)以(Yi)及(Ji)暴(Bao)露(Lu)的(De)人(Ren)口(Kou)和(He)牲(Sheng)畜(Xu)数(Shu)量(Liang)进(Jin)行(Xing)了(Liao)全(Quan)球(Qiu)评(Ping)估(Gu)。在(Zai)世(Shi)界(Jie)范(Fan)围(Wei)内(Nei)，金(Jin)属(Shu)矿(Kuang)山(Shan)影(Ying)响(Xiang)着(Zhuo)47.92万(Wan)公(Gong)里(Li)的(De)河(He)道(Dao)和(He)16.4万(Wan)平(Ping)方(Fang)公(Gong)里(Li)的(De)洪(Hong)泛(Fan)平(Ping)原(Yuan)。长(Chang)期(Qi)向(Xiang)河(He)流(Liu)排(Pai)放(Fang)采(Cai)矿(Kuang)废(Fei)物(Wu)所(Suo)造(Zao)成(Cheng)污(Wu)染(Ran)的(De)人(Ren)数(Shu)几(Ji)乎(Hu)是(Shi)直(Zhi)接(Jie)受(Shou)尾(Wei)矿(Kuang)坝(Ba)溃(Kui)坝(Ba)影(Ying)响(Xiang)人(Ren)数(Shu)的(De)50倍(Bei)。▲ Abstract：An estimated 23 million people live on floodplains affected by potentially dangerous concentrations of toxic waste derived from past and present metal mining activity. We analyzed the global dimensions of this hazard, particularly in regard to lead, zinc, copper, and arsenic, using a georeferenced global database detailing all known metal mining sites and intact and failed tailings storage facilities. We then used process-based and empirically tested modeling to produce a global assessment of metal mining contamination in river systems and the numbers of human populations and livestock exposed. Worldwide, metal mines affect 479,200 kilometers of river channels and 164,000 square kilometers of floodplains. The number of people exposed to contamination sourced from long-term discharge of mining waste into rivers is almost 50 times greater than the number directly affected by tailings dam failures.生(Sheng)物(Wu)学(Xue)BiologyAccurate proteome-wide missense variant effect prediction with AlphaMissense利(Li)用(Yong)AlphaMissense预(Yu)测(Ce)蛋(Dan)白(Bai)质(Zhi)组(Zu)错(Cuo)义(Yi)变(Bian)异(Yi)效(Xiao)应(Ying)▲ 作(Zuo)者(Zhe)：JUN CHENG, GUIDO NOVATI, JOSHUA PAN, CLARE BYCROFT, AKVIL? ?EMGULYT?, TAYLOR APPLEBAUM, ALEXANDER PRITZEL, LAI HONG WONG, MICHAL ZIELINSKI, AND ?IGA AVSEC▲ 链(Lian)接(Jie)：https://www.science.org/doi/full/10.1126/science.adh9059▲ 摘(Zhai)要(Yao)：在(Zai)人(Ren)类(Lei)基(Ji)因(Yin)组(Zu)中(Zhong)观(Guan)察(Cha)到(Dao)的(De)绝(Jue)大(Da)多(Duo)数(Shu)错(Cuo)义(Yi)变(Bian)异(Yi)具(Ju)有(You)未(Wei)知(Zhi)的(De)临(Lin)床(Chuang)意(Yi)义(Yi)。研(Yan)究(Jiu)者(Zhe)开(Kai)发(Fa)了(Liao)AlphaMissense，这(Zhe)是(Shi)一(Yi)种(Zhong)基(Ji)于(Yu)蛋(Dan)白(Bai)质(Zhi)结(Jie)构(Gou)预(Yu)测(Ce)工(Gong)具(Ju)AlphaFold2的(De)深(Shen)度(Du)学(Xue)习(Xi)模(Mo)型(Xing)。通(Tong)过(Guo)AlphaMissense对(Dui)人(Ren)类(Lei)和(He)灵(Ling)长(Chang)类(Lei)动(Dong)物(Wu)变(Bian)异(Yi)种(Zhong)群(Qun)频(Pin)率(Lv)数(Shu)据(Ju)库(Ku)进(Jin)行(Xing)微(Wei)调(Diao)，以(Yi)预(Yu)测(Ce)错(Cuo)义(Yi)变(Bian)异(Yi)的(De)致(Zhi)病(Bing)性(Xing)。通(Tong)过(Guo)结(Jie)合(He)结(Jie)构(Gou)背(Bei)景(Jing)和(He)进(Jin)化(Hua)守(Shou)恒(Heng)，该(Gai)模(Mo)型(Xing)在(Zai)广(Guang)泛(Fan)的(De)遗(Yi)传(Chuan)和(He)实(Shi)验(Yan)基(Ji)准(Zhun)中(Zhong)获(Huo)得(De)了(Liao)最(Zui)先(Xian)进(Jin)的(De)结(Jie)果(Guo)，这(Zhe)些(Xie)都(Du)没(Mei)有(You)在(Zai)数(Shu)据(Ju)上(Shang)进(Jin)行(Xing)明(Ming)确(Que)的(De)训(Xun)练(Lian)。基(Ji)因(Yin)的(De)平(Ping)均(Jun)致(Zhi)病(Bing)性(Xing)评(Ping)分(Fen)也(Ye)可(Ke)以(Yi)预(Yu)测(Ce)它(Ta)们(Men)的(De)重(Zhong)要(Yao)性(Xing)，能(Neng)够(Gou)识(Shi)别(Bie)现(Xian)有(You)统(Tong)计(Ji)方(Fang)法(Fa)无(Wu)法(Fa)检(Jian)测(Ce)到(Dao)的(De)短(Duan)必(Bi)要(Yao)基(Ji)因(Yin)。研(Yan)究(Jiu)者(Zhe)提(Ti)供(Gong)了(Liao)一(Yi)个(Ge)数(Shu)据(Ju)库(Ku)，预(Yu)测(Ce)所(Suo)有(You)可(Ke)能(Neng)的(De)人(Ren)类(Lei)单(Dan)氨(An)基(Ji)酸(Suan)替(Ti)换(Huan)，并(Bing)将(Jiang)89%的(De)错(Cuo)义(Yi)变(Bian)异(Yi)分(Fen)类(Lei)为(Wei)可(Ke)能(Neng)是(Shi)良(Liang)性(Xing)的(De)或(Huo)可(Ke)能(Neng)是(Shi)致(Zhi)病(Bing)的(De)。▲ Abstract：The vast majority of missense variants observed in the human genome are of unknown clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on human and primate variant population frequency databases to predict missense variant pathogenicity. By combining structural context and evolutionary conservation, our model achieves state-of-the-art results across a wide range of genetic and experimental benchmarks, all without explicitly training on such data. The average pathogenicity score of genes is also predictive for their cell essentiality, capable of identifying short essential genes that existing statistical approaches are underpowered to detect. As a resource to the community, we provide a database of predictions for all possible human single amino acid substitutions and classify 89% of missense variants as either likely benign or likely pathogenic.
因为蔬菜上面不但会有灰尘和细菌，而且还会有一定的农药残留，用水冲洗，是能够很好解决这些问题的。心梗，也就是心肌梗塞，通常是因为心脏的冠状动脉突然阻塞，导致心肌无法得到充足的血液供应。那么，心梗都有哪些症状呢？除了胸痛，心梗的患者还可能出现冷汗、恶心、呼吸困难等症状。这些信号其实都是身体在向我们求救，告诉我们心脏正处在危险中。云卿颜东方寒(云卿颜东方寒小说)最新章节全文免费阅读冲笔趣阁
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