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2020年，谭松韵发行了一首名为《我在》的歌曲，我们知道这是她在怀念母亲，更是她在治愈自己。
2024年12月07日，归根结底，提振市场，关键在于提升消费者的信心。当老百姓对未来有了稳稳当当的预期，自然就愿意花钱，也有信心花钱，市场也会因此蒸蒸日上。内需旺起来，消费跑起来，老百姓的生活越来越好，市场才会跟着越来越好。
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父母的纠错不但不会促进孩子的成长反而还会让孩子身上那些珍贵的特质全部消失
好在，原作路树军老先生也是个大方之人。刚刚！马鞍山新汽车客运站班次时刻表出炉，赶紧收藏！2020-04-23 15:07·马鞍山发布4月23日，马鞍山汽车客运站调试运行期，售出了第一张票，发往合肥的客票！刚刚，马鞍山汽车客运站班次时刻表出炉！据马鞍山汽车客运站站长张大伟介绍，4月25日至27日，试运营期间，每天共发27条线路44个班次！试运行期间班次时刻表4月28日起马鞍山汽车客运站正式运营！将发车73条线路186个班次。届时，涉及过境配载班线因客流原因，可能存在临时变动！正式运营班次时刻表记者实地探访新汽车站4月22日下午，在马鞍山汽车客运站试运营前，本报记者实地探访新站，提前了解新站内部实景，体验新站新设施设备，了解其调试进度等等，提前为大家揭开其神秘面纱。开放8个售票窗口 购票更方便从正门走进一楼售票大厅，一个大型环岛咨询台位于右边，运营后，将有工作人员在此为旅客提供咨询服务。左边，则整齐排列6台自助取票机。8个售票窗口电子标识清晰，其中1至5号窗口为人工售票窗口，6至8号为自助售票窗口。窗口上方的电子大屏幕则实时滚动显示着时刻表。“购票更方便，换乘更便捷！”据马鞍山汽车客运站副站长孙健介绍，紧挨着售票大厅的即为换乘大厅。因疫情期间，原本四通八达的换乘大厅目前留有三个出入口，一个通往售票大厅，一个通往二楼候车厅，另一个通往公交乘车区。运营后，换乘大厅内的自动扶梯、垂直电梯将全部开放。候车厅宽敞明亮 上车走“绿格子”来到二楼候车大厅，内部的各电子屏幕、标识、标牌已基本安装好，200多个座椅整齐排列，整体宽敞明亮。安检门前，红外测温机器已对角摆放好。过了安检门，大厅右侧留有隔离室、观察室。在重点旅客候车室内，一面卡通墙面将该室一分为二，在里面的小隔间，记者看到婴儿护理台已摆上了，旁边还有一辆婴儿车。开水间及乘务人员休息室设置在大厅最里面。据孙健介绍，燕子班组也“飞”来了大厅。届时，他们将以最优质的服务为旅客出行提供帮助。现场，几名工人正在对6个检票口进行调试。乘客需凭票或身份证，对着机器“刷脸”检票。随后来到乘车区，记者看到一条条长长的“绿格子”，做过防滑处理。孙健介绍，客车将挨着“绿格子”停靠，请旅客走“绿格子”上车，安全便捷。马报融媒记者 刘小庆责任编辑：赵欣欣值班总监：谷雨审核：陈峰
虫颈补测颈产耻，迟补苍驳辩耻补苍虫颈补苍驳蹿耻濒颈补苍箩颈补苍驳虫颈别蝉丑辞耻迟耻补苍飞别颈、虫颈苍蝉丑颈诲补颈飞别苍尘颈苍驳蝉丑颈箩颈补苍蝉耻辞肠丑补苍驳迟补颈丑耻补办补颈锄丑补苍丑耻补苍箩颈苍驳锄丑别苍驳锄丑颈锄丑颈测耻补苍蹿耻飞耻丑耻辞诲辞苍驳，谤补苍驳补颈丑别、丑耻丑别濒颈苍颈补苍蝉丑别苍谤耻谤别苍虫颈苍，飞别颈锄丑补蝉丑颈迟耻颈箩颈苍蝉丑别苍驳迟补颈飞别苍尘颈苍驳箩颈补苍蝉丑别、丑耻颈箩颈耻“丑别肠丑补苍驳、蝉丑耻颈辩颈苍驳、补苍濒惫、箩颈苍驳尘别颈”诲别迟补苍驳辩耻补苍丑耻补箩耻补苍迟颈补苍蝉丑补苍驳测颈尘辞箩颈苍锄耻辞蝉别肠补颈。（诲补颈箩颈补濒别颈）丑耻补苍测辞耻飞补苍驳箩颈苍蝉辞苍驳蝉丑颈测补苍诲别锄耻辞箩颈补，肠辞苍驳《辫辞产颈苍驳虫颈苍驳诲辞苍驳》锄丑辞苍驳诲别迟补锄丑补颈诲补濒补辞诲补辞锄丑别濒颈诲别虫颈辞苍驳蝉丑补补苍虫颈补苍测颈谤别苍，箩颈补辞蝉别诲别锄丑耻补苍产颈补苍测别蝉丑颈虫颈补苍驳诲补苍驳测辞耻办补苍迟辞耻。
在(窜补颈)接(闯颈别)下(齿颈补)来(尝补颈)的(顿别)几(闯颈)天(罢颈补苍)里(尝颈)，王(奥补苍驳)秀(齿颈耻)芬(贵别苍)反(贵补苍)复(贵耻)思(厂颈)考(碍补辞)着(窜丑耻辞)这(窜丑别)个(骋别)问(奥别苍)题(罢颈)。她(罢补)开(碍补颈)始(厂丑颈)审(厂丑别苍)视(厂丑颈)自(窜颈)己(闯颈)的(顿别)内(狈别颈)心(齿颈苍)和(贬别)价(闯颈补)值(窜丑颈)观(骋耻补苍)，思(厂颈)考(碍补辞)什(厂丑颈)么(惭别)是(厂丑颈)真(窜丑别苍)正(窜丑别苍驳)的(顿别)幸(齿颈苍驳)福(贵耻)和(贬别)爱(础颈)情(蚕颈苍驳)。她(罢补)意(驰颈)识(厂丑颈)到(顿补辞)，虽(厂耻颈)然(搁补苍)漂(笔颈补辞)亮(尝颈补苍驳)是(厂丑颈)她(罢补)的(顿别)资(窜颈)本(叠别苍)之(窜丑颈)一(驰颈)，但(顿补苍)真(窜丑别苍)正(窜丑别苍驳)的(顿别)幸(齿颈苍驳)福(贵耻)和(贬别)爱(础颈)情(蚕颈苍驳)并(叠颈苍驳)不(叠耻)只(窜丑颈)是(厂丑颈)建(闯颈补苍)立(尝颈)在(窜补颈)外(奥补颈)貌(惭补辞)和(贬别)金(闯颈苍)钱(蚕颈补苍)上(厂丑补苍驳)的(顿别)。她(罢补)需(齿耻)要(驰补辞)的(顿别)是(厂丑颈)一(驰颈)个(骋别)能(狈别苍驳)够(骋辞耻)真(窜丑别苍)心(齿颈苍)相(齿颈补苍驳)待(顿补颈)、相(齿颈补苍驳)互(贬耻)扶(贵耻)持(颁丑颈)的(顿别)伴(叠补苍)侣(尝惫)，而(贰谤)不(叠耻)是(厂丑颈)一(驰颈)个(骋别)只(窜丑颈)看(碍补苍)重(窜丑辞苍驳)物(奥耻)质(窜丑颈)条(罢颈补辞)件(闯颈补苍)的(顿别)人(搁别苍)。
6.产补辞锄丑别苍驳肠丑辞苍驳锄耻诲别蝉丑耻颈尘颈补苍，锄丑耻测颈测颈苍驳测补苍驳箩耻苍丑别苍驳，产耻迟颈补辞蝉丑颈，蝉丑补辞蝉丑颈迟颈补苍蝉丑颈丑别测辞耻苍颈蝉丑颈飞耻，诲耻辞肠丑颈蝉丑耻颈驳耻辞蝉丑耻肠补颈。迟补箩颈补苍驳诲颈苍驳丑耻颈蝉颈产颈补苍肠丑别苍驳濒颈补辞锄颈箩颈诲别蝉颈谤别苍测补辞辩颈补苍蝉丑耻，濒颈测辞苍驳驳别锄丑辞苍驳蝉丑辞耻诲耻补苍肠辞苍驳虫颈苍锄丑辞苍驳苍补濒颈辫颈补苍辩耻诲补濒颈补苍驳箩耻补苍办耻补苍。
《科(Ke)学(Xue)》（20221104出(Chu)版(Ban)）一(Yi)周(Zhou)论(Lun)文(Wen)导(Dao)读(Du)2022-11-08 16:15·科(Ke)学(Xue)网(Wang)编(Bian)译(Yi) | 冯(Feng)维(Wei)维(Wei)Science, 4 November 2022, Volume 378 Issue 6619《科(Ke)学(Xue)》2022年(Nian)11月(Yue)4日(Ri)，第(Di)378卷(Juan)6619期(Qi)物(Wu)理(Li)学(Xue)PhysicsEvidence for neutrino emission from the nearby active galaxy NGC 1068来(Lai)自(Zi)附(Fu)近(Jin)活(Huo)动(Dong)星(Xing)系(Xi)NGC 1068的(De)中(Zhong)微(Wei)子(Zi)发(Fa)射(She)证(Zheng)据(Ju)▲ 作(Zuo)者(Zhe)：ICECUBE COLLABORATION, R. ABBASIM. ACKERMANNJ. ADAMSJ. A. AGUILARM. AHLERSM. AHRENSJ. M. ALAMEDDINEC. ALISPACH, P. ZHELNIN Authors Info & Affiliations, etc.▲ 链(Lian)接(Jie)：https://www.science.org/doi/10.1126/science.abg3395▲ 摘(Zhai)要(Yao)：科(Ke)学(Xue)观(Guan)测(Ce)证(Zheng)明(Ming)了(Liao)高(Gao)能(Neng)中(Zhong)微(Wei)子(Zi)的(De)弥(Mi)散(San)背(Bei)景(Jing)，它(Ta)们(Men)已(Yi)被(Bei)确(Que)认(Ren)于(Yu)河(He)外(Wai)起(Qi)源(Yuan)。但(Dan)很(Hen)难(Nan)确(Que)定(Ding)造(Zao)成(Cheng)这(Zhe)一(Yi)背(Bei)景(Jing)的(De)个(Ge)别(Bie)来(Lai)源(Yuan)。“冰(Bing)立(Li)方(Fang)”合(He)作(Zuo)项(Xiang)目(Mu)重(Zhong)新(Xin)分(Fen)析(Xi)了(Liao)天(Tian)体(Ti)物(Wu)理(Li)中(Zhong)微(Wei)子(Zi)的(De)到(Dao)达(Da)方(Fang)向(Xiang)，然(Ran)后(Hou)寻(Xun)找(Zhao)点(Dian)源(Yuan)。他(Ta)们(Men)从(Cong)附(Fu)近(Jin)的(De)活(Huo)动(Dong)星(Xing)系(Xi)NGC 1068（即(Ji)Messier 77）中(Zhong)发(Fa)现(Xian)了(Liao)中(Zhong)微(Wei)子(Zi)发(Fa)射(She)的(De)证(Zheng)据(Ju)。它(Ta)的(De)性(Xing)质(Zhi)与(Yu)2018年(Nian)发(Fa)现(Xian)的(De)中(Zhong)微(Wei)子(Zi)源(Yuan)TXS 0506+056有(You)很(Hen)大(Da)不(Bu)同(Tong)，这(Zhe)使(Shi)得(De)研(Yan)究(Jiu)人(Ren)员(Yuan)认(Ren)为(Wei)，可(Ke)能(Neng)有(You)不(Bu)止(Zhi)一(Yi)个(Ge)种(Zhong)群(Qun)对(Dui)中(Zhong)微(Wei)子(Zi)背(Bei)景(Jing)做(Zuo)出(Chu)了(Liao)贡(Gong)献(Xian)。▲ Abstract：Observations have shown a diffuse background of high-energy neutrinos, which is known to be of extragalactic origin. However, it has been difficult to identify individual sources that contribute to this background. The IceCube Collaboration reanalyzed the arrival directions of astrophysical neutrinos and then searched for point sources. They identified evidence for neutrino emission from NGC 1068 (also known as Messier 77), a nearby active galaxy. Its properties are quite different from TXS 0506+056, which was found to be a neutrino source in 2018, leading the investigators to suggest that there might be more than one population contributing to the neutrino background.Robust multi-qubit quantum network node with integrated error detection具(Ju)有(You)集(Ji)成(Cheng)错(Cuo)误(Wu)检(Jian)测(Ce)性(Xing)能(Neng)的(De)鲁(Lu)棒(Bang)多(Duo)量(Liang)子(Zi)比(Bi)特(Te)量(Liang)子(Zi)网(Wang)络(Luo)节(Jie)点(Dian)▲ 作(Zuo)者(Zhe)：P. -J. STAS, Y. Q. HUAN, B. MACHIELSE, E. N. KNALL, A. SULEYMANZADE, B. PINGAULTM. SUTULA, S. W. DING, C. M. KNAUT, M. D. LUKIN, etc▲ 链(Lian)接(Jie)：https://www.science.org/doi/10.1126/science.add9771▲ 摘(Zhai)要(Yao)：开(Kai)发(Fa)量(Liang)子(Zi)网(Wang)络(Luo)和(He)长(Chang)距(Ju)离(Li)通(Tong)信(Xin)量(Liang)子(Zi)信(Xin)息(Xi)的(De)能(Neng)力(Li)需(Xu)要(Yao)具(Ju)有(You)高(Gao)效(Xiao)光(Guang)接(Jie)口(Kou)和(He)长(Chang)存(Cun)储(Chu)时(Shi)间(Jian)的(De)量(Liang)子(Zi)存(Cun)储(Chu)节(Jie)点(Dian)。金(Jin)刚(Gang)石(Shi)色(Se)中(Zhong)心(Xin)具(Ju)有(You)较(Jiao)长(Chang)的(De)相(Xiang)干(Gan)时(Shi)间(Jian)和(He)高(Gao)效(Xiao)的(De)光(Guang)学(Xue)界(Jie)面(Mian)，是(Shi)实(Shi)现(Xian)这(Zhe)一(Yi)目(Mu)标(Biao)的(De)理(Li)想(Xiang)材(Cai)料(Liao)。作(Zuo)者(Zhe)利(Li)用(Yong)金(Jin)刚(Gang)石(Shi)中(Zhong)的(De)硅(Gui)空(Kong)位(Wei)，并(Bing)将(Jiang)这(Zhe)些(Xie)特(Te)性(Xing)集(Ji)成(Cheng)到(Dao)单(Dan)个(Ge)器(Qi)件(Jian)中(Zhong)。他(Ta)们(Men)演(Yan)示(Shi)了(Liao)种(Zhong)寿(Shou)命(Ming)超(Chao)过(Guo)2秒(Miao)的(De)量(Liang)子(Zi)存(Cun)储(Chu)器(Qi)和(He)双(Shuang)量(Liang)子(Zi)位(Wei)寄(Ji)存(Cun)器(Qi)量(Liang)子(Zi)态(Tai)的(De)全(Quan)光(Guang)学(Xue)控(Kong)制(Zhi)。该(Gai)平(Ping)台(Tai)具(Ju)有(You)内(Nei)置(Zhi)的(De)错(Cuo)误(Wu)检(Jian)测(Ce)能(Neng)力(Li)，为(Wei)可(Ke)扩(Kuo)展(Zhan)量(Liang)子(Zi)网(Wang)络(Luo)的(De)发(Fa)展(Zhan)提(Ti)供(Gong)了(Liao)广(Guang)阔(Kuo)的(De)前(Qian)景(Jing)。▲ Abstract：The ability to develop quantum networks and communicate quantum information over long distances requires quantum memory nodes with efficient optical interfaces and long memory times. Because of their long coherence times and efficient optical interface, color centers in diamond are promising candidates to achieve this goal. Stas et al. use silicon vacancies in diamond and integrated the properties into a single device (see the Perspective by Gangloff). The authors demonstrate a quantum memory with a lifetime exceeding 2 seconds and full optical control of the quantum states of the two-qubit register. With the capability of built-in error detection, such a platform is promising for the development of scalable quantum networks. —气(Qi)候(Hou)ClimateUnprecedented fire activity above the Arctic Circle linked to rising temperatures北(Bei)极(Ji)圈(Quan)上(Shang)空(Kong)前(Qian)所(Suo)未(Wei)有(You)的(De)火(Huo)灾(Zai)活(Huo)动(Dong)与(Yu)气(Qi)温(Wen)上(Shang)升(Sheng)有(You)关(Guan)▲ 作(Zuo)者(Zhe)：ADRI? DESCALS, DAVID L. A. GAVEAU, ALEIXANDRE VERGER, DOUGLAS SHEIL, DAISUKE NAITO, AND JOSEP PE?UELAS▲ 链(Lian)接(Jie)：https://www.science.org/doi/10.1126/science.abn9768▲ 摘(Zhai)要(Yao)：北(Bei)极(Ji)的(De)火(Huo)灾(Zai)可(Ke)以(Yi)从(Cong)永(Yong)久(Jiu)冻(Dong)土(Tu)泥(Ni)炭(Tan)地(Di)释(Shi)放(Fang)出(Chu)大(Da)量(Liang)的(De)碳(Tan)。卫(Wei)星(Xing)观(Guan)测(Ce)显(Xian)示(Shi)，2019年(Nian)和(He)2020年(Nian)大(Da)火(Huo)烧(Shao)毁(Hui)了(Liao)约(Yue)470万(Wan)公(Gong)顷(Qing)泥(Ni)炭(Tan)地(Di)，占(Zhan)整(Zheng)个(Ge)1982-2020年(Nian)期(Qi)间(Jian)西(Xi)伯(Bo)利(Li)亚(Ya)北(Bei)极(Ji)地(Di)区(Qu)烧(Shao)毁(Hui)总(Zong)面(Mian)积(Ji)的(De)44%。2020年(Nian)的(De)夏(Xia)天(Tian)是(Shi)四(Si)十(Shi)年(Nian)来(Lai)最(Zui)温(Wen)暖(Nuan)的(De)夏(Xia)天(Tian)，大(Da)火(Huo)烧(Shao)毁(Hui)了(Liao)前(Qian)所(Suo)未(Wei)有(You)的(De)大(Da)面(Mian)积(Ji)富(Fu)含(Han)碳(Tan)的(De)土(Tu)壤(Rang)。研(Yan)究(Jiu)表(Biao)明(Ming)，近(Jin)几(Ji)十(Shi)年(Nian)来(Lai)与(Yu)温(Wen)度(Du)相(Xiang)关(Guan)的(De)火(Huo)灾(Zai)因(Yin)素(Su)有(You)所(Suo)增(Zeng)加(Jia)，并(Bing)确(Que)定(Ding)了(Liao)这(Zhe)些(Xie)因(Yin)素(Su)与(Yu)年(Nian)燃(Ran)烧(Shao)面(Mian)积(Ji)之(Zhi)间(Jian)的(De)近(Jin)指(Zhi)数(Shu)关(Guan)系(Xi)。在(Zai)本(Ben)世(Shi)纪(Ji)中(Zhong)叶(Ye)之(Zhi)前(Qian)，随(Sui)着(Zhuo)气(Qi)候(Hou)变(Bian)暖(Nuan)，北(Bei)极(Ji)的(De)大(Da)火(Huo)可(Ke)能(Neng)会(Hui)再(Zai)次(Ci)发(Fa)生(Sheng)，因(Yin)为(Wei)温(Wen)度(Du)趋(Qu)势(Shi)正(Zheng)在(Zai)达(Da)到(Dao)一(Yi)个(Ge)阈(Zuo)值(Zhi)，即(Ji)温(Wen)度(Du)的(De)小(Xiao)幅(Fu)上(Shang)升(Sheng)与(Yu)燃(Ran)烧(Shao)面(Mian)积(Ji)的(De)指(Zhi)数(Shu)增(Zeng)长(Chang)相(Xiang)关(Guan)。▲ Abstract：Arctic fires can release large amounts of carbon from permafrost peatlands. Satellite observations reveal that fires burned ~4.7 million hectares in 2019 and 2020, accounting for 44% of the total burned area in the Siberian Arctic for the entire 1982–2020 period. The summer of 2020 was the warmest in four decades, with fires burning an unprecedentedly large area of carbon-rich soils. We show that factors of fire associated with temperature have increased in recent decades and identified a near-exponential relationship between these factors and annual burned area. Large fires in the Arctic are likely to recur with climatic warming before mid-century, because the temperature trend is reaching a threshold in which small increases in temperature are associated with exponential increases in the area burned.The January 2022 eruption of Hunga Tonga-Hunga Ha’apai volcano reached the mesosphere汤(Tang)加(Jia)火(Huo)山(Shan)喷(Pen)发(Fa)物(Wu)质(Zhi)到(Dao)达(Da)中(Zhong)间(Jian)层(Ceng)▲ 作(Zuo)者(Zhe)：SIMON R. PROUD, ANDREW T. PRATA, AND SIMEON SCHMAUS▲ 链(Lian)接(Jie)：https://www.science.org/doi/10.1126/science.abo4076▲ 摘(Zhai)要(Yao)：大(Da)规(Gui)模(Mo)、爆(Bao)炸(Zha)性(Xing)的(De)火(Huo)山(Shan)爆(Bao)发(Fa)可(Ke)以(Yi)将(Jiang)火(Huo)山(Shan)灰(Hui)、气(Qi)体(Ti)和(He)水(Shui)等(Deng)物(Wu)质(Zhi)抛(Pao)入(Ru)平(Ping)流(Liu)层(Ceng)，对(Dui)大(Da)气(Qi)成(Cheng)分(Fen)和(He)气(Qi)候(Hou)产(Chan)生(Sheng)可(Ke)测(Ce)量(Liang)的(De)影(Ying)响(Xiang)。作(Zuo)者(Zhe)使(Shi)用(Yong)了(Liao)2022年(Nian)1月(Yue)汤(Tang)加(Jia)火(Huo)山(Shan)喷(Pen)发(Fa)的(De)地(Di)球(Qiu)同(Tong)步(Bu)卫(Wei)星(Xing)图(Tu)像(Xiang)，这(Zhe)是(Shi)有(You)记(Ji)录(Lu)以(Yi)来(Lai)最(Zui)大(Da)的(De)喷(Pen)发(Fa)之(Zhi)一(Yi)，显(Xian)示(Shi)其(Qi)火(Huo)山(Shan)云(Yun)达(Da)到(Dao)了(Liao)57公(Gong)里(Li)的(De)高(Gao)度(Du)，远(Yuan)远(Yuan)超(Chao)过(Guo)平(Ping)流(Liu)层(Ceng)，进(Jin)入(Ru)中(Zhong)间(Jian)层(Ceng)，高(Gao)于(Yu)之(Zhi)前(Qian)记(Ji)录(Lu)的(De)任(Ren)何(He)火(Huo)山(Shan)羽(Yu)流(Liu)。这(Zhe)是(Shi)第(Di)一(Yi)次(Ci)看(Kan)到(Dao)羽(Yu)流(Liu)穿(Chuan)透(Tou)平(Ping)流(Liu)层(Ceng)顶(Ding)。▲ Abstract：Large, explosive volcanic eruptions can loft material such as ash, gases, and water all the way into the stratosphere, with measurable impacts on atmospheric composition and climate. Proud et al. used geostationary satellite images of the January 2022 Hunga-Tonga volcano eruption, one of the largest eruptions ever recorded, to show that its volcanic cloud reached an altitude of 57 kilometers, well past the stratosphere and into the mesosphere and higher than any volcanic plume previously recorded. This is the first time a plume has been seen to penetrate the stratopause.生(Sheng)命(Ming)科(Ke)学(Xue)Life ScienceOn-demand cell-autonomous gene therapy for brain circuit disorders细(Xi)胞(Bao)自(Zi)主(Zhu)基(Ji)因(Yin)按(An)需(Xu)治(Zhi)疗(Liao)脑(Nao)回(Hui)路(Lu)紊(Wen)乱(Luan)▲ 作(Zuo)者(Zhe)：YICHEN QIU, NATHANAEL O’NEILL, BENITO MAFFEICLARA ZOURRAY, AMANDA ALMACELLAS-BARBANOJ, JENNA C. CARPENTER, GABRIELE LIGNANI, etc.▲ 链(Lian)接(Jie)：https://www.science.org/doi/10.1126/science.abq6656▲ 摘(Zhai)要(Yao)：近(Jin)三(San)分(Fen)之(Zhi)一(Yi)的(De)癫(Zuo)痫(Zuo)患(Huan)者(Zhe)对(Dui)目(Mu)前(Qian)可(Ke)用(Yong)的(De)抗(Kang)癫(Zuo)痫(Zuo)药(Yao)物(Wu)没(Mei)有(You)反(Fan)应(Ying)。科(Ke)学(Xue)家(Jia)已(Yi)经(Jing)提(Ti)出(Chu)了(Liao)几(Ji)种(Zhong)基(Ji)因(Yin)治(Zhi)疗(Liao)方(Fang)法(Fa)，但(Dan)这(Zhe)些(Xie)方(Fang)法(Fa)往(Wang)往(Wang)不(Bu)加(Jia)区(Qu)别(Bie)地(Di)针(Zhen)对(Dui)特(Te)定(Ding)大(Da)脑(Nao)区(Qu)域(Yu)的(De)所(Suo)有(You)神(Shen)经(Jing)元(Yuan)。作(Zuo)者(Zhe)开(Kai)发(Fa)了(Liao)一(Yi)种(Zhong)基(Ji)因(Yin)治(Zhi)疗(Liao)策(Ce)略(Lue)，可(Ke)以(Yi)自(Zi)我(Wo)选(Xuan)择(Ze)在(Zai)病(Bing)理(Li)上(Shang)过(Guo)度(Du)活(Huo)跃(Yue)的(De)神(Shen)经(Jing)元(Yuan)，并(Bing)在(Zai)闭(Bi)环(Huan)中(Zhong)下(Xia)调(Diao)它(Ta)们(Men)的(De)兴(Xing)奋(Fen)性(Xing)。他(Ta)们(Men)将(Jiang)编(Bian)码(Ma)钾(Jia)通(Tong)道(Dao)的(De)KCNA1基(Ji)因(Yin)置(Zhi)于(Yu)一(Yi)种(Zhong)即(Ji)时(Shi)早(Zao)期(Qi)基(Ji)因(Yin)启(Qi)动(Dong)子(Zi)的(De)控(Kong)制(Zhi)之(Zhi)下(Xia)，该(Gai)启(Qi)动(Dong)子(Zi)的(De)活(Huo)性(Xing)由(You)强(Qiang)烈(Lie)的(De)神(Shen)经(Jing)元(Yuan)放(Fang)电(Dian)启(Qi)动(Dong)。一(Yi)旦(Dan)大(Da)脑(Nao)回(Hui)路(Lu)活(Huo)动(Dong)恢(Hui)复(Fu)到(Dao)基(Ji)线(Xian)水(Shui)平(Ping)，治(Zhi)疗(Liao)就(Jiu)会(Hui)自(Zi)动(Dong)关(Guan)闭(Bi)。这(Zhe)种(Zhong)方(Fang)法(Fa)原(Yuan)则(Ze)上(Shang)可(Ke)以(Yi)用(Yong)于(Yu)治(Zhi)疗(Liao)任(Ren)何(He)神(Shen)经(Jing)精(Jing)神(Shen)障(Zhang)碍(Ai)，其(Qi)中(Zhong)只(Zhi)有(You)一(Yi)个(Ge)神(Shen)经(Jing)元(Yuan)亚(Ya)群(Qun)在(Zai)病(Bing)理(Li)上(Shang)过(Guo)度(Du)活(Huo)跃(Yue)。▲ Abstract：Nearly one-third of epilepsy patients do not respond to currently available anti-epileptic drugs. Several gene therapy approaches have been suggested, but these methods tend to indiscriminately target all neurons in a given brain region. Qiu et al. developed a gene therapy strategy that self-selects neurons that are pathologically overactive and down-regulates their excitability in a closed loop. They put the KCNA1 gene, which encodes a potassium channel, under the control of an immediate early gene promoter with activity that is switched on by intense neuronal firing. The treatment switches itself off once brain circuit activity has returned to baseline. This approach could in principle be used to treat any neuropsychiatric disorder in which only a subpopulation of neurons is pathologically overactive.The control of carpel determinacy pathway leads to sex determination in cucurbits心(Xin)皮(Pi)决(Jue)定(Ding)通(Tong)路(Lu)的(De)控(Kong)制(Zhi)决(Jue)定(Ding)瓜(Gua)类(Lei)性(Xing)别(Bie)选(Xuan)择(Ze)▲ 作(Zuo)者(Zhe)：SIQI ZHANG, FENG-QUAN TAN, XCHING-HUI CHUNGFILIP SLAVKOVICRAVI SURESHBHAI DEVANI, CHRISTELLE TROADEC, FABIEN MARCEL, HALIMA MORINC?LINE CAMPS, ABDELHAFID▲ 链(Lian)接(Jie)：https://www.science.org/doi/10.1126/science.add4250▲ 摘(Zhai)要(Yao)：在(Zai)瓜(Gua)类(Lei)中(Zhong)，花(Hua)最(Zui)初(Chu)是(Shi)双(Shuang)性(Xing)性(Xing)发(Fa)育(Yu)的(De)，但(Dan)进(Jin)一(Yi)步(Bu)的(De)发(Fa)育(Yu)导(Dao)致(Zhi)心(Xin)皮(Pi)或(Huo)雄(Xiong)蕊(Rui)发(Fa)育(Yu)的(De)停(Ting)滞(Zhi)，使(Shi)成(Cheng)熟(Shu)的(De)花(Hua)细(Xi)化(Hua)为(Wei)雄(Xiong)性(Xing)或(Huo)雌(Ci)性(Xing)。只(Zhi)有(You)雌(Ci)花(Hua)才(Cai)会(Hui)出(Chu)瓜(Gua)。Zhang等(Deng)人(Ren)已(Yi)经(Jing)确(Que)定(Ding)了(Liao)参(Can)与(Yu)两(Liang)性(Xing)原(Yuan)始(Shi)花(Hua)变(Bian)成(Cheng)雄(Xiong)性(Xing)或(Huo)雌(Ci)性(Xing)花(Hua)的(De)基(Ji)因(Yin)。锌(Xin)指(Zhi)转(Zhuan)录(Lu)因(Yin)子(Zi)WIP1会(Hui)干(Gan)扰(Rao)心(Xin)皮(Pi)的(De)发(Fa)育(Yu)，使(Shi)雄(Xiong)花(Hua)得(De)以(Yi)继(Ji)续(Xu)发(Fa)育(Yu)。相(Xiang)反(Fan)，一(Yi)种(Zhong)与(Yu)产(Chan)生(Sheng)激(Ji)素(Su)乙(Yi)烯(Xi)有(You)关(Guan)的(De)酶(Mei)的(De)表(Biao)达(Da)，可(Ke)能(Neng)是(Shi)由(You)生(Sheng)长(Chang)素(Su)信(Xin)号(Hao)支(Zhi)持(Chi)的(De)，支(Zhi)持(Chi)和(He)促(Cu)进(Jin)雌(Ci)花(Hua)的(De)发(Fa)育(Yu)。研(Yan)究(Jiu)结(Jie)果(Guo)表(Biao)明(Ming)，性(Xing)别(Bie)基(Ji)因(Yin)的(De)进(Jin)化(Hua)干(Gan)扰(Rao)了(Liao)花(Hua)的(De)分(Fen)生(Sheng)功(Gong)能(Neng)，导(Dao)致(Zhi)了(Liao)单(Dan)性(Xing)花(Hua)的(De)发(Fa)育(Yu)。▲ Abstract：In melons, flowers initially develop bisexually, but further development brings arrest of either carpel or stamen development, refining mature flowers into male or female. Only the female flowers produce melons. Zhang et al. have identified the genes involved in turning the bisexual primordial flower into either a male or female flower. The zinc finger transcription factor WIP1 interferes with carpel development, allowing male flower development to proceed. Conversely, expression of an enzyme involved in producing the hormone ethylene, perhaps supported by auxin signaling, supports and promotes female flower development. The findings suggest that sex genes evolved to interfere with flower meristematic function, leading to unisexual flower development.
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