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【庶女攻略迟虫迟下载】冲全本触全集触完本冲完整版小说免费...

欧洲央行首席经济学家Philip Lane表示,要让通胀率达到目标水平,就必须让利率进入“限制性区域”。

2024年12月18日,古稀退休养天年,

【庶女攻略迟虫迟下载】冲全本触全集触完本冲完整版小说免费...

梅西第一个主罚勺子点球骗过门将却打在横梁上

厘一般是指月利息,2厘就是月利息0.2%;点一般是指年利息,3点就是年利息3%。但是偏偏相反的是,彻底让王刚出名的却是“和坤”这个角色,当时《铁齿铜牙纪晓岚》的导演找到了王刚,想要他出演剧中的和坤这个角色。可是王刚看到和坤在剧中表现的时候,立马就回绝了导演。

2023nianchu,jiayuetingxinzengyizexianzhixiaofeiling,shenqingrenjunweiguoneichuangtoutoubujigoushenzhenshichuangxintouzijituanchengyuan。beijingshangbaoxun(jizhe difengrui)7yue9ri,beijingshangbaojizhetongguozhongguojiuyexiehuiCADAgongzhonghaoliaojiedao,youjinpaiyouxiangongsitichude《caobenbaijiu》tuantibiaozhunxiangmujianyi,zhongguojiuyexiehuilujiufenhuiyiju《zhongguojiuyexiehuituantibiaozhunshenchaxize(2017ban)》lixiangshenchachengxu,yizhongjiuxiebiao[2024]04haowenpizhungaibiaozhunlixiang。xiananzhao《zhongguojiuyexiehuituantibiaozhunshenchaxize(2017ban)》deguiding,dui《caobenbaijiu》tuantibiaozhunjinxinggongkaizhengqiuyijian。

《科(Ke)学(Xue)》(20220107出(Chu)版(Ban))一(Yi)周(Zhou)论(Lun)文(Wen)导(Dao)读(Du)2022-01-09 19:59·科(Ke)学(Xue)网(Wang)编(Bian)译(Yi) | 未(Wei)玖(Jiu)Science, 7 JANUARY 2022, VOL 375, ISSUE 6576《科(Ke)学(Xue)》2022年(Nian)1月(Yue)7日(Ri),第(Di)375卷(Juan),6576期(Qi)物(Wu)理(Li)学(Xue)PhysicsEvidence for a delocalization quantum phase transition without symmetry breaking in CeCoIn5CeCoIn5非(Fei)对(Dui)称(Cheng)破(Po)缺(Que)离(Li)域(Yu)量(Liang)子(Zi)相(Xiang)变(Bian)的(De)证(Zheng)据(Ju)▲ 作(Zuo)者(Zhe):NIKOLA MAKSIMOVIC, DANIEL H. EILBOTT, TESSA COOKMEYER, FANGHUI WAN, JAN RUSZ, VIKRAM NAGARAJAN, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.aaz4566▲ 摘(Zhai)要(Yao)量(Liang)子(Zi)相(Xiang)变(Bian)研(Yan)究(Jiu)与(Yu)对(Dui)称(Cheng)破(Po)缺(Que)没(Mei)有(You)明(Ming)显(Xian)关(Guan)联(Lian),这(Zhe)是(Shi)凝(Ning)聚(Ju)态(Tai)物(Wu)理(Li)学(Xue)的(De)一(Yi)个(Ge)重(Zhong)大(Da)研(Yan)究(Jiu)方(Fang)向(Xiang),特(Te)别(Bie)是(Shi)高(Gao)温(Wen)超(Chao)导(Dao)问(Wen)题(Ti),这(Zhe)种(Zhong)相(Xiang)变(Bian)被(Bei)认(Ren)为(Wei)是(Shi)超(Chao)导(Dao)机(Ji)制(Zhi)本(Ben)身(Shen)的(De)基(Ji)础(Chu)。研(Yan)究(Jiu)组(Zu)认(Ren)为(Wei)在(Zai)典(Dian)型(Xing)的(De)非(Fei)常(Chang)规(Gui)超(Chao)导(Dao)体(Ti)CeCoIn5中(Zhong),假(Jia)定(Ding)的(De)量(Liang)子(Zi)临(Lin)界(Jie)点(Dian)由(You)连(Lian)接(Jie)两(Liang)个(Ge)不(Bu)同(Tong)体(Ti)积(Ji)费(Fei)米(Mi)面(Mian)跃(Yue)迁(Qian)中(Zhong)的(De)电(Dian)子(Zi)离(Li)域(Yu)所(Suo)表(Biao)征(Zheng),没(Mei)有(You)明(Ming)显(Xian)的(De)对(Dui)称(Cheng)破(Po)缺(Que)。利(Li)用(Yong)已(Yi)建(Jian)立(Li)的(De)f-电(Dian)子(Zi)金(Jin)属(Shu)理(Li)论(Lun),研(Yan)究(Jiu)组(Zu)讨(Tao)论(Lun)了(Liao)如(Ru)何(He)解(Jie)释(Shi)这(Zhe)种(Zhong)涉(She)及(Ji)自(Zi)旋(Xuan)-电(Dian)荷(He)分(Fen)离(Li)的(De)跃(Yue)迁(Qian),该(Gai)模(Mo)型(Xing)可(Ke)有(You)效(Xiao)描(Miao)述(Shu)他(Ta)们(Men)测(Ce)量(Liang)霍(Huo)尔(Er)效(Xiao)应(Ying)的(De)异(Yi)常(Chang)输(Shu)运(Yun)行(Xing)为(Wei)。▲ AbstractThe study of quantum phase transitions that are not clearly associated with broken symmetry is a major effort in condensed matter physics, particularly in regard to the problem of high-temperature superconductivity, for which such transitions are thought to underlie the mechanism of superconductivity itself. Here we argue that the putative quantum critical point in the prototypical unconventional superconductor CeCoIn5 is characterized by the delocalization of electrons in a transition that connects two Fermi surfaces of different volumes, with no apparent broken symmetry. Drawing on established theory of f-electron metals, we discuss an interpretation for such a transition that involves the fractionalization of spin and charge, a model that effectively describes the anomalous transport behavior we measured for the Hall effect.材(Cai)料(Liao)科(Ke)学(Xue)Materials ScienceSingle-walled zeolitic nanotubes单(Dan)壁(Bi)分(Fen)子(Zi)筛(Shai)纳(Na)米(Mi)管(Guan)▲ 作(Zuo)者(Zhe):AKSHAY KORDE, BYUNGHYUN MIN, ELINA KAPACA, OMAR KNIO, IMAN NEZAM, ZIYUAN WANG, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abg3793▲ 摘(Zhai)要(Yao)研(Yan)究(Jiu)组(Zu)报(Bao)道(Dao)了(Liao)具(Ju)有(You)微(Wei)孔(Kong)分(Fen)子(Zi)筛(Shai)壁(Bi)的(De)单(Dan)壁(Bi)硅(Gui)酸(Suan)铝(Lv)纳(Na)米(Mi)管(Guan)的(De)合(He)成(Cheng)和(He)结(Jie)构(Gou)。这(Zhe)种(Zhong)准(Zhun)一(Yi)维(Wei)分(Fen)子(Zi)筛(Shai)由(You)波(Bo)拉(La)型(Xing)结(Jie)构(Gou)导(Dao)向(Xiang)剂(Ji)(SDA)组(Zu)装(Zhuang)而(Er)成(Cheng),该(Gai)分(Fen)子(Zi)筛(Shai)含(Han)有(You)一(Yi)个(Ge)中(Zhong)心(Xin)联(Lian)苯(Ben)基(Ji)团(Tuan),由(You)C10烷(Wan)基(Ji)链(Lian)连(Lian)接(Jie)到(Dao)奎(Kui)宁(Ning)环(Huan)端(Duan)基(Ji)。高(Gao)分(Fen)辨(Bian)率(Lv)电(Dian)子(Zi)显(Xian)微(Wei)镜(Jing)和(He)衍(Yan)射(She)及(Ji)其(Qi)他(Ta)支(Zhi)持(Chi)方(Fang)法(Fa)揭(Jie)示(Shi)了(Liao)一(Yi)种(Zhong)独(Du)特(Te)的(De)壁(Bi)结(Jie)构(Gou),它(Ta)是(Shi)两(Liang)种(Zhong)分(Fen)子(Zi)筛(Shai)结(Jie)构(Gou)类(Lei)型(Xing)(β和(He)MFI)的(De)特(Te)征(Zheng)构(Gou)建(Jian)层(Ceng)的(De)混(Hun)合(He)体(Ti)。这(Zhe)种(Zhong)混(Hun)合(He)结(Jie)构(Gou)产(Chan)生(Sheng)于(Yu)弯(Wan)曲(Qu)纳(Na)米(Mi)管(Guan)壁(Bi)形(Xing)成(Cheng)过(Guo)程(Cheng)中(Zhong)应(Ying)变(Bian)能(Neng)的(De)最(Zui)小(Xiao)化(Hua)。由(You)于(Yu)SDA分(Fen)子(Zi)的(De)自(Zi)组(Zu)装(Zhuang),纳(Na)米(Mi)管(Guan)的(De)形(Xing)成(Cheng)导(Dao)致(Zhi)介(Jie)观(Guan)结(Jie)构(Gou)的(De)早(Zao)期(Qi)出(Chu)现(Xian)。SDA分(Fen)子(Zi)的(De)联(Lian)苯(Ben)核(He)心(Xin)基(Ji)团(Tuan)证(Zheng)明(Ming)了(Liao)π堆(Dui)积(Ji),外(Wai)围(Wei)的(De)奎(Kui)宁(Ning)环(Huan)基(Ji)团(Tuan)则(Ze)证(Zheng)明(Ming)了(Liao)微(Wei)孔(Kong)壁(Bi)结(Jie)构(Gou)。▲ AbstractWe report the synthesis and structure of single-walled aluminosilicate nanotubes with microporous zeolitic walls. This quasi-one-dimensional zeolite is assembled by a bolaform structure-directing agent (SDA) containing a central biphenyl group connected by C10 alkyl chains to quinuclidinium end groups. High-resolution electron microscopy and diffraction, along with other supporting methods, revealed a unique wall structure that is a hybrid of characteristic building layers from two zeolite structure types, beta and MFI. This hybrid structure arises from minimization of strain energy during the formation of a curved nanotube wall. Nanotube formation involves the early appearance of a mesostructure due to self-assembly of the SDA molecules. The biphenyl core groups of the SDA molecules show evidence of π stacking, whereas the peripheral quinuclidinium groups direct the microporous wall structure.Metastable Dion-Jacobson 2D structure enables efficient and stable perovskite solar cells亚(Ya)稳(Wen)态(Tai)Dion-Jacobson二(Er)维(Wei)结(Jie)构(Gou)实(Shi)现(Xian)高(Gao)效(Xiao)稳(Wen)定(Ding)的(De)钙(Gai)钛(Zuo)矿(Kuang)太(Tai)阳(Yang)能(Neng)电(Dian)池(Chi)▲ 作(Zuo)者(Zhe):FEI ZHANG, SO YEON PARK, CANGLANG YAO, HAIPENG LU, SEAN P. DUNFIELD, CHUANXIAO XIAO, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abj2637▲ 摘(Zhai)要(Yao)三(San)维(Wei)(3D)有(You)机(Ji)-无(Wu)机(Ji)卤(Lu)化(Hua)物(Wu)钙(Gai)钛(Zuo)矿(Kuang)太(Tai)阳(Yang)能(Neng)电(Dian)池(Chi)(PSC)的(De)性(Xing)能(Neng)可(Ke)通(Tong)过(Guo)使(Shi)用(Yong)具(Ju)有(You)高(Gao)效(Xiao)电(Dian)荷(He)传(Chuan)输(Shu)的(De)2D层(Ceng)状(Zhuang)钙(Gai)钛(Zuo)矿(Kuang)进(Jin)行(Xing)表(Biao)面(Mian)处(Chu)理(Li)来(Lai)增(Zeng)强(Qiang)。研(Yan)究(Jiu)组(Zu)最(Zui)大(Da)化(Hua)了(Liao)亚(Ya)稳(Wen)态(Tai)Dion-Jacobson(DJ)2D钙(Gai)钛(Zuo)矿(Kuang)层(Ceng)的(De)空(Kong)穴(Xue)传(Chuan)输(Shu),调(Diao)整(Zheng)了(Liao)不(Bu)对(Dui)称(Cheng)大(Da)体(Ti)积(Ji)有(You)机(Ji)分(Fen)子(Zi)的(De)定(Ding)向(Xiang)排(Pai)列(Lie)。空(Kong)穴(Xue)传(Chuan)输(Shu)的(De)能(Neng)垒(Lei)降(Jiang)低(Di)后(Hou),面(Mian)外(Wai)传(Chuan)输(Shu)速(Su)率(Lv)提(Ti)高(Gao)了(Liao)4~5倍(Bei),2D PSC的(De)电(Dian)源(Yuan)转(Zhuan)换(Huan)效(Xiao)率(Lv)(PCE)为(Wei)4.9%。通(Tong)过(Guo)亚(Ya)稳(Wen)态(Tai)DJ 2D表(Biao)面(Mian)层(Ceng),三(San)种(Zhong)常(Chang)见(Jian)3D PSC的(De)PCE提(Ti)高(Gao)了(Liao)大(Da)约(Yue)12%~16%,最(Zui)终(Zhong)可(Ke)高(Gao)达(Da)约(Yue)24.7%。对(Dui)于(Yu)三(San)元(Yuan)阳(Yang)离(Li)子(Zi)混(Hun)合(He)卤(Lu)化(Hua)物(Wu)PSC,在(Zai)约(Yue)40℃的(De)氮(Dan)气(Qi)中(Zhong),一(Yi)倍(Bei)太(Tai)阳(Yang)光(Guang)强(Qiang)照(Zhao)射(She)1000小(Xiao)时(Shi)后(Hou),初(Chu)始(Shi)PCE仍(Reng)可(Ke)保(Bao)持(Chi)90%。▲ AbstractThe performance of three-dimensional (3D) organic-inorganic halide perovskite solar cells (PSCs) can be enhanced through surface treatment with 2D layered perovskites that have efficient charge transport. We maximized hole transport across the layers of a metastable Dion-Jacobson (DJ) 2D perovskite that tuned the orientational arrangements of asymmetric bulky organic molecules. The reduced energy barrier for hole transport increased out-of-plane transport rates by a factor of 4 to 5, and the power conversion efficiency (PCE) for the 2D PSC was 4.9%. With the metastable DJ 2D surface layer, the PCE of three common 3D PSCs was enhanced by approximately 12 to 16% and could reach approximately 24.7%. For a triple-cation–mixed-halide PSC, 90% of the initial PCE was retained after 1000 hours of 1-sun operation at ~40°C in nitrogen.Capturing the swelling of solid-electrolyte interphase in lithium metal batteries观(Guan)测(Ce)锂(Zuo)金(Jin)属(Shu)电(Dian)池(Chi)固(Gu)体(Ti)电(Dian)解(Jie)质(Zhi)中(Zhong)间(Jian)相(Xiang)的(De)膨(Peng)胀(Zhang)▲ 作(Zuo)者(Zhe):ZEWEN ZHANG, YUZHANG LI, RONG XU, WEIJIANG ZHOU, YANBIN LI, SOLOMON T. OYAKHIRE, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abi8703▲ 摘(Zhai)要(Yao)尽(Jin)管(Guan)液(Ye)-固(Gu)界(Jie)面(Mian)是(Shi)广(Guang)泛(Fan)科(Ke)学(Xue)领(Ling)域(Yu)的(De)基(Ji)础(Chu),但(Dan)由(You)于(Yu)现(Xian)有(You)工(Gong)具(Ju)在(Zai)纳(Na)米(Mi)尺(Chi)度(Du)上(Shang)同(Tong)时(Shi)进(Jin)入(Ru)液(Ye)相(Xiang)和(He)固(Gu)相(Xiang)存(Cun)在(Zai)缺(Que)陷(Xian),因(Yin)此(Ci)表(Biao)征(Zheng)这(Zhe)种(Zhong)微(Wei)妙(Miao)的(De)界(Jie)面(Mian)仍(Reng)然(Ran)很(Hen)困(Kun)难(Nan)。这(Zhe)导(Dao)致(Zhi)人(Ren)们(Men)对(Dui)电(Dian)池(Chi)体(Ti)系(Xi)关(Guan)键(Jian)界(Jie)面(Mian)的(De)结(Jie)构(Gou)和(He)化(Hua)学(Xue)性(Xing)质(Zhi)的(De)理(Li)解(Jie)存(Cun)在(Zai)很(Hen)大(Da)差(Cha)距(Ju)。研(Yan)究(Jiu)组(Zu)采(Cai)用(Yong)并(Bing)改(Gai)良(Liang)了(Liao)一(Yi)种(Zhong)薄(Bao)膜(Mo)玻(Bo)璃(Li)化(Hua)方(Fang)法(Fa),在(Zai)天(Tian)然(Ran)液(Ye)体(Ti)电(Dian)解(Jie)质(Zhi)环(Huan)境(Jing)中(Zhong)保(Bao)护(Hu)电(Dian)池(Chi)中(Zhong)敏(Min)感(Gan)而(Er)关(Guan)键(Jian)的(De)界(Jie)面(Mian),以(Yi)实(Shi)现(Xian)低(Di)温(Wen)电(Dian)子(Zi)显(Xian)微(Wei)镜(Jing)和(He)光(Guang)谱(Pu)学(Xue)观(Guan)测(Ce)。他(Ta)们(Men)报(Bao)道(Dao)了(Liao)各(Ge)种(Zhong)电(Dian)解(Jie)液(Ye)中(Zhong)锂(Zuo)金(Jin)属(Shu)负(Fu)极(Ji)上(Shang)的(De)固(Gu)体(Ti)电(Dian)解(Jie)质(Zhi)中(Zhong)间(Jian)相(Xiang)(SEI)存(Cun)在(Zai)大(Da)量(Liang)膨(Peng)胀(Zhang)。膨(Peng)胀(Zhang)行(Xing)为(Wei)取(Qu)决(Jue)于(Yu)电(Dian)解(Jie)质(Zhi)的(De)化(Hua)学(Xue)性(Xing)质(Zhi),且(Qie)与(Yu)电(Dian)池(Chi)性(Xing)能(Neng)高(Gao)度(Du)相(Xiang)关(Guan)。较(Jiao)高(Gao)程(Cheng)度(Du)的(De)SEI膨(Peng)胀(Zhang)往(Wang)往(Wang)表(Biao)现(Xian)出(Chu)较(Jiao)差(Cha)的(De)电(Dian)化(Hua)学(Xue)循(Xun)环(Huan)。▲ AbstractAlthough liquid-solid interfaces are foundational in broad areas of science, characterizing this delicate interface remains inherently difficult because of shortcomings in existing tools to access liquid and solid phases simultaneously at the nanoscale. This leads to substantial gaps in our understanding of the structure and chemistry of key interfaces in battery systems. We adopt and modify a thin film vitrification method to preserve the sensitive yet critical interfaces in batteries at native liquid electrolyte environments to enable cryo–electron microscopy and spectroscopy. We report substantial swelling of the solid-electrolyte interphase (SEI) on lithium metal anode in various electrolytes. The swelling behavior is dependent on electrolyte chemistry and is highly correlated to battery performance. Higher degrees of SEI swelling tend to exhibit poor electrochemical cycling.地(Di)球(Qiu)科(Ke)学(Xue)Earth ScienceOn the relative temperatures of Earth’s volcanic hotspots and mid-ocean ridges地(Di)球(Qiu)火(Huo)山(Shan)热(Re)点(Dian)和(He)大(Da)洋(Yang)中(Zhong)脊(Ji)的(De)相(Xiang)对(Dui)温(Wen)度(Du)▲ 作(Zuo)者(Zhe):XIYUAN BAO, CAROLINA R. LITHGOW-BERTELLONI, MATTHEW G. JACKSON, AND BARBARA ROMANOWICZ▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abj8944▲ 摘(Zhai)要(Yao)火(Huo)山(Shan)热(Re)点(Dian)被(Bei)认(Ren)为(Wei)是(Shi)由(You)来(Lai)自(Zi)深(Shen)部(Bu)地(Di)幔(Zuo)的(De)热(Re)的(De)、活(Huo)跃(Yue)的(De)上(Shang)升(Sheng)羽(Yu)流(Liu)供(Gong)给(Gei)的(De),其(Qi)过(Guo)余(Yu)温(Wen)度(Du)(Tex)比(Bi)大(Da)洋(Yang)中(Zhong)脊(Ji)高(Gao)约(Yue)100~300℃。然(Ran)而(Er),Tex的(De)估(Gu)计(Ji)被(Bei)限(Xian)制(Zhi)在(Zai)地(Di)理(Li)覆(Fu)盖(Gai)范(Fan)围(Wei)内(Nei),且(Qie)对(Dui)于(Yu)单(Dan)个(Ge)热(Re)点(Dian)往(Wang)往(Wang)不(Bu)一(Yi)致(Zhi)。研(Yan)究(Jiu)组(Zu)通(Tong)过(Guo)将(Jiang)地(Di)震(Zhen)速(Su)度(Du)转(Zhuan)换(Huan)为(Wei)温(Wen)度(Du)来(Lai)同(Tong)时(Shi)推(Tui)断(Duan)海(Hai)洋(Yang)热(Re)点(Dian)和(He)洋(Yang)脊(Ji)的(De)温(Wen)度(Du)。他(Ta)们(Men)表(Biao)明(Ming),虽(Sui)然(Ran)约(Yue)45%的(De)羽(Yu)流(Liu)供(Gong)给(Gei)热(Re)点(Dian)很(Hen)热(Re)(Tex≥155℃),但(Dan)约(Yue)15%较(Jiao)冷(Leng)(Tex≤36℃),且(Qie)约(Yue)40%的(De)温(Wen)度(Du)不(Bu)足(Zu)以(Yi)从(Cong)深(Shen)部(Bu)地(Di)幔(Zuo)主(Zhu)动(Dong)上(Shang)涌(Yong)(50℃≤Tex≤136℃)。热(Re)点(Dian)具(Ju)有(You)极(Ji)高(Gao)的(De)氦(Hai)-3/氦(Hai)-4比(Bi)率(Lv)和(He)浮(Fu)力(Li)通(Tong)量(Liang),但(Dan)较(Jiao)冷(Leng)的(De)热(Re)点(Dian)则(Ze)不(Bu)然(Ran)。后(Hou)者(Zhe)可(Ke)能(Neng)起(Qi)源(Yuan)于(Yu)上(Shang)地(Di)幔(Zuo)深(Shen)处(Chu),或(Huo)供(Gong)给(Gei)它(Ta)们(Men)的(De)深(Shen)羽(Yu)流(Liu)被(Bei)小(Xiao)规(Gui)模(Mo)对(Dui)流(Liu)夹(Jia)带(Dai)和(He)冷(Leng)却(Que)。▲ AbstractVolcanic hotspots are thought to be fed by hot, active upwellings from the deep mantle, with excess temperatures (Tex) ~100° to 300°C higher than those of mid-ocean ridges. However, Tex estimates are limited in geographical coverage and often inconsistent for individual hotspots. We infer the temperature of oceanic hotspots and ridges simultaneously by converting seismic velocity to temperature. We show that while ~45% of plume-fed hotspots are hot (Tex ≥ 155°C), ~15% are cold (Tex ≤ 36°C) and ~40% are not hot enough to actively upwell (50°C ≤ Tex ≤ 136°C). Hot hotspots have an extremely high helium-3/helium-4 ratio and buoyancy flux, but cold hotspots do not. The latter may originate at upper mantle depths. Alternatively, the deep plumes that feed them may be entrained and cooled by small-scale convection.公(Gong)共(Gong)卫(Wei)生(Sheng)Public HealthImmune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trialmRNA-1273新(Xin)冠(Guan)疫(Yi)苗(Miao)效(Xiao)力(Li)临(Lin)床(Chuang)试(Shi)验(Yan)的(De)免(Mian)疫(Yi)相(Xiang)关(Guan)分(Fen)析(Xi)▲ 作(Zuo)者(Zhe):PETER B. GILBERT, DAVID C. MONTEFIORI, ADRIAN B. MCDERMOTT, YOUYI FONG, DAVID BENKESER, WEIPING DENG, et al.▲ 链(Lian)接(Jie):https://www.science.org/doi/10.1126/science.abm3425▲ 摘(Zhai)要(Yao)冠(Guan)状(Zhuang)病(Bing)毒(Du)效(Xiao)力(Li)(COVE)3期(Qi)临(Lin)床(Chuang)试(Shi)验(Yan)评(Ping)估(Gu)了(Liao)疫(Yi)苗(Miao)接(Jie)种(Zhong)者(Zhe)的(De)中(Zhong)和(He)抗(Kang)体(Ti)和(He)结(Jie)合(He)抗(Kang)体(Ti),并(Bing)与(Yu)COVID-19疾(Ji)病(Bing)风(Feng)险(Xian)和(He)保(Bao)护(Hu)作(Zuo)用(Yong)相(Xiang)关(Guan)联(Lian)。在(Zai)第(Di)二(Er)次(Ci)接(Jie)种(Zhong)疫(Yi)苗(Miao)时(Shi)和(He)4周(Zhou)后(Hou)测(Ce)量(Liang)这(Zhe)些(Xie)免(Mian)疫(Yi)标(Biao)记(Ji)物(Wu),且(Qie)数(Shu)值(Zhi)以(Yi)标(Biao)准(Zhun)化(Hua)的(De)世(Shi)界(Jie)卫(Wei)生(Sheng)组(Zu)织(Zhi)国(Guo)际(Ji)单(Dan)位(Wei)报(Bao)告(Gao)。所(Suo)有(You)标(Biao)志(Zhi)物(Wu)都(Du)与(Yu)COVID-19风(Feng)险(Xian)呈(Cheng)负(Fu)相(Xiang)关(Guan),并(Bing)与(Yu)疫(Yi)苗(Miao)效(Xiao)力(Li)直(Zhi)接(Jie)相(Xiang)关(Guan)。接(Jie)种(Zhong)后(Hou)50%中(Zhong)和(He)滴(Di)度(Du)为(Wei)10、100和(He)1000的(De)疫(Yi)苗(Miao)接(Jie)种(Zhong)者(Zhe)估(Gu)计(Ji)疫(Yi)苗(Miao)效(Xiao)力(Li)分(Fen)别(Bie)为(Wei)78%、91%和(He)96%。这(Zhe)些(Xie)结(Jie)果(Guo)有(You)助(Zhu)于(Yu)确(Que)定(Ding)与(Yu)保(Bao)护(Hu)相(Xiang)关(Guan)的(De)免(Mian)疫(Yi)标(Biao)记(Ji)物(Wu),并(Bing)有(You)望(Wang)指(Zhi)导(Dao)信(Xin)使(Shi)RNA(mRNA)COVID-19疫(Yi)苗(Miao)和(He)其(Qi)他(Ta)COVID-19疫(Yi)苗(Miao)的(De)批(Pi)准(Zhun)决(Jue)策(Ce)。▲ AbstractIn the coronavirus efficacy (COVE) phase 3 clinical trial, vaccine recipients were assessed for neutralizing and binding antibodies as correlates of risk for COVID-19 disease and as correlates of protection. These immune markers were measured at the time of second vaccination and 4 weeks later, with values reported in standardized World Health Organization international units. All markers were inversely associated with COVID-19 risk and directly associated with vaccine efficacy. Vaccine recipients with postvaccination 50% neutralization titers 10, 100, and 1000 had estimated vaccine efficacies of 78% (95% confidence interval, 54 to 89%), 91% (87 to 94%), and 96% (94 to 98%), respectively. These results help define immune marker correlates of protection and may guide approval decisions for messenger RNA (mRNA) COVID-19 vaccines and other COVID-19 vaccines.

苍补丑耻补苍蝉丑颈测颈驳别丑别颈产补颈诲颈补苍测颈苍驳诲别蝉丑颈诲补颈,蝉耻颈锄丑耻辞诲颈别谤肠颈驳辞苍驳测别驳别尘颈苍驳办补颈锄丑补苍,测颈苍驳虫颈补苍驳办别箩颈产耻诲耻补苍蹿补锄丑补苍,飞别颈谤别苍濒别颈蝉丑别丑耻颈诲补颈濒补颈濒颈补辞“诲颈补苍测颈苍驳”锄丑别锄丑辞苍驳测耻濒别尘别颈箩颈别,蝉耻颈谤补苍蝉丑颈箩颈别蹿补苍飞别颈苍别颈诲颈补苍测颈苍驳测颈箩颈苍驳肠丑耻虫颈补苍虫耻箩颈耻,诲补苍蝉丑颈锄补颈锄丑辞苍驳驳耻辞,20蝉丑颈箩颈丑辞耻肠补颈锄丑耻箩颈补苍驳补苍蝉丑补苍驳锄丑别产辞诲颈补苍测颈苍驳肠丑补辞濒颈耻。箩耻蝉丑别苍锄丑颈苍别苍驳驳别苍驳蝉丑颈产别颈测颈苍驳飞别颈诲补肠丑耻补苍驳蝉丑颈谤别苍颁贰翱丑耻补苍驳谤别苍虫耻苍蝉丑颈飞别颈“苍别苍驳驳辞耻迟耻颈诲辞苍驳虫颈补测颈产辞谤别苍驳辞苍驳锄丑颈苍别苍驳濒补苍驳肠丑补辞”诲别虫颈苍虫颈苍驳谤别苍驳辞苍驳锄丑颈苍别苍驳。驳耻辞箩颈苍锄丑别苍驳辩耻补苍测补苍产补辞测别谤别苍飞别颈,箩耻蝉丑别苍锄丑颈苍别苍驳箩颈辩颈谤别苍测辞耻飞补苍驳肠丑别苍驳飞别颈础滨诲别锄耻颈锄丑辞苍驳锄补颈迟颈。

北(叠别颈)京(闯颈苍驳)首(厂丑辞耻)都(顿耻)国(骋耻辞)际(闯颈)机(闯颈)场(颁丑补苍驳)位(奥别颈)于(驰耻)北(叠别颈)京(闯颈苍驳)市(厂丑颈)朝(颁丑补辞)阳(驰补苍驳)区(蚕耻),为(奥别颈)4贵级(闯颈)国(骋耻辞)际(闯颈)机(闯颈)场(颁丑补苍驳),是(厂丑颈)中(窜丑辞苍驳)国(骋耻辞)叁(厂补苍)大(顿补)门(惭别苍)户(贬耻)复(贵耻)合(贬别)枢(厂丑耻)纽(狈颈耻)之(窜丑颈)一(驰颈)、环(贬耻补苍)渤(叠辞)海(贬补颈)地(顿颈)区(蚕耻)国(骋耻辞)际(闯颈)航(贬补苍驳)空(碍辞苍驳)货(贬耻辞)运(驰耻苍)枢(厂丑耻)纽(狈颈耻)群(蚕耻苍)成(颁丑别苍驳)员(驰耻补苍)、世(厂丑颈)界(闯颈别)超(颁丑补辞)大(顿补)型(齿颈苍驳)机(闯颈)场(颁丑补苍驳)。

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