欧洲一卡二卡叁乱码新区据说加入了一键选择功能,平台表示:支持...
一个是初出茅庐的创业者，一个是久经商场的投资者，“星动不廷”组合在这里碰撞出了别样的浪漫火花。“天选韩廷、纪星，真的很难不让人心动。”“韩廷他真的超爱，纪星她真的值得！”观众纷纷表示。
2025年01月08日，生肖羊：温柔守候，静待花开
欧洲一卡二卡叁乱码新区据说加入了一键选择功能,平台表示:支持...
我叫李明今年四十岁是个普通的公司职员和妻子张梅结婚十年有一个八岁的儿子小伟我们一家住在城郊的一栋老式公寓里生活虽然不算富裕但也算平稳生活中的点滴总是带着些许平淡的温馨直到一个不速之客打破了这一切——她就是住在我们隔壁的李大妈
小暑前后，饮食宜少寒凉，常吃4样，清热降火开胃补虚，强壮身体斯巴鲁驰鹏是斯巴鲁生产的一款跨界车，它结合了轿车的舒适性和厂鲍痴的越野能力。驰鹏提供了强大的全轮驱动系统和较高的离地间隙，适合各种路况和天气条件。
“xiangduiqunian，jinnianSjidedaxiangmutebieduo，gedapingtaitouruyedubijiaoda，zhiyaoyouhaodexiangmupingtaikendinghuijiadatouru，erqiejidapingtaizhijianduzaiqiangpaipinzhihaodexiangmu。”zhangzuoshuo。cong3dao6，zuozuFlyme OSjingliliaonaxietuibian2017-03-31 05:21·zhongguancunzaixianzuozukeyishuoshizuizaozhudagongjiangjingshendechangshang，jiangmeixuejiaruUIshejiyizhishiqitesesuozai。zhengyinweiruci，zuozuzongnengxiyinyiqunzhongshidefensiyonghu。zuoweiyonghuyujiqijiaohudeniudai，Flymeyizhibanyanzhuozhongyaodejiaose，danqizuoliquezaiqiaorangaibian。weihegaibian，jiuqigenben，bujinjinshidanchundegengxinhuandainamejiandan。cong3dao6，zuozuFlyme OSjingliliaonaxietuibianzaidangjindeguochanshoujidingzhihuaxitongzhong，Flymeyijingyongyouwanshandegongnengtiyanyuguangdadeyonghuqunti，keyiyuxiaomideMIUI、huaweideEMUIbingjiaqiqu。danbizhezuichujiechudaodeFlyme 3，queshiyixiaoermeidexingxiangchuxiande。Flymecongtadexiaoermeidaorujindedazhonghua，daodijingliliaonaxietuibian？shishimecuchengliaozhexietuibiandechansheng？zhexietuibianyougeizuozudailailiaoshimeyangdehaochu？bizheyiyiweinixiangjie。pingpanbutongshoujixitong，yibanduhuicongguangansheji、jiaohutiyanhexitonggongnengsanfangmianlaijinxingduibi。buguancongnagefangmianlaishuo，Flymeyizhiduyongyouqidutezhichu。guanganyongyoumingxiandezuozufengge danbujuyuelaiyuequyudazhonghuaFlymegeirendediyiganjuejiushijianyuedute，erqiezhezhonggeirendeganjuebingmeiyousuizhuoxitongbanbendeshengjierxiaoshi。congFlyme 3zuozujiuxuanzeliaobianpinghuadeUIsheji，bingqiejiangzhezhongbianpingdefenggeyizhiyanyongzhijin。Flyme 3Flyme 4 Flyme 5 Flyme 6congFlyme 3daoFlyme 5，tubiaohuizhishejishangbingmeiyoushimetaidadegaidong，Flyme 6secaigengjiaxianyanyixie，xiangduiyuMIUInazhongyuanjiaojuxingdetubiaosheji，Flymeyuanxinghedailengjiaojuxingdetubiaoshejigengxianfengfuduocai，dujuzuozufengge，zheyeshiFlymetubiaobianshidujiaogaodeyuanyinzhiyi。zongtilaishuo，zuozudeUIshejiyimaixiangcheng，secaiyuelaiyuejiejinnianqingtai，bingqieyuelaiyuefengfudeguodudonghuarangxitongbiandekanqilaigengyougediao。Flyme 3Flyme 4 Flyme 5 Flyme 6Flyme 3tongzhilanweixialaxuanfushi，congFlyme 4gaichengquanpingmumaobolixiaoguo。tongzhilantubiaochuFlyme 5waijunyicuxiantiaohuizhi，congFlyme 4kaishijunyiyuanxinganniuchengxian，guanganshangbiandegengjiaguizhengxiediao。Flyme 3Flyme 4 Flyme 5 Flyme 6yingyongjiemianfangmian，Flyme 3secaishedingxiangduidanyi，congFlyme 4kaishi，jiemiansecaiyijingjibendingxing。yemianbujushejicongFlyme 3daoFlyme 4youbijiaodadegaiban，congFlyme 4daoFlyme 5，zuozugexinghuadeyuansubiandegengshaoyixie，gengpianxiangyudazhonghua，qizhongdianxingjiushiwenjianguanliheshezhideyemianbujugaiban。Flyme 3Flyme 4 Flyme 5 Flyme 6xiangduiyuqitazhuliuxitong，Flyme 4daoFlyme 5gengduodekeyishuoshimianxiangdazhonghuadegaiban。congMX4kaishi，zuozushoujidexiaoliangkuaisushangsheng，dutegexingdexiaoermeixianranyijingbushihezuozudefazhan，zuozuxuyaobaxitongzhongyuanziqiduxingduduandeyuansutihuanchengfuhedazhongshenmeidechengfen。suiranzheyangFlymekanqilaihuigengjiapingyong，danqihoudexiaoliangquegeichuzhengming，zuozuzheyangdegaibanlidayubi。Flyme 3Flyme 4 Flyme 5 Flyme 6zuozushijiaohu jiaohujiedelingtouyangdutedejiaohufangshiyizhishizuozudeyoushisuozai。xiangxinyouhenduorenduhuigenbizheyiyang，beiMX3dexiaoyuanquanHomejianjingyandao。xiaoyuanquanbujinkeyidangzuoHOMEjian，erqiekeyidaitichuantongdehuxidengjinxingbutongliangdujibiedexinxitixing。peihexiaoyuanquan，Flyme 3jiangjiaohufangshizuodaoliaojizhi——congxiaoyuanquanshanghuajiesuopingmu，liangpingshitongyangdedongzuokeyizuoweifanhuijian，changanxipingdengdeng。zaidangshideanzhuojihuanpubiandushisandajinganganjiandeshidai，zuozulvxianzuochuliaoxiedaizuozutesedejiaohufangshi，yizhiyudaohoulaizuozubuzaishiyongxiaoyuanquan，henduorentiqixiaoyuanquanshi，huannenghuainianMX3dejingdiansheji。zuozuzaijiaohufangmianyizhichuzailingxiandiwei。congMX4 PROkaishi，zuozufangqixiaoyuanquansheji，gaiyongjichengzhiwenshibiedeshitimTouchanjian。zhengmiankeanyashizhiwenzaidangshideanzhuozhenyingzhongjihuhuanchuzaiyizhangbaizhidezhuangtai，zuozulvxianshiyongcizhiwenfangan，tupozhongzhongjishukunnan，rangjiyukeanyashiHOMEjiandejiaohuyongyoulianghaodetiyan。zaidaohoulaizuolannote2caiyongquanxinyaoyuananjianshejiyuyandemBackwuliHomejian，keyishixianyigeanjiandeduogongnengcaozuo，rangyonghutiyanzaicishengji。zhenduikeanyashideHomejian，Flyme 4quxiaoliaoSmart Bar，daohoulaideFlyme 5，zuozujixuduiyemianjiaohufangshijinxingjingjiangaijin，jiangdibudefenleidaohanglanchediyichu，yejiushishuo，zuozubajiaohudezhongxinzhuanyidaoliaombackgongnengshang，jiaoweitongyidejiaohufangshirangxuexichengbenjiangdaoliaozuidi。Flyme 3Flyme 4 Flyme 5 Flyme 6suiranquxiaodiaoxiaoyuanquandesheji，danshiFlymebaoliuliaoxiaoyuanquande“linghun”——xuanfuqiu。zaiFlyme 4zhong，xuanfuqiudejiarugeijiaohudailailiaojidadebianli。tongguoxuanfuqiu，yonghukeyishixianyingyongqiehuan、suoping、guanbidangqianyingyongdengcaozuo，weidapingmushoujidedanshoucaozuodailailiaokenengxing，erqiezaihouxudexitongzhong，xuanfuqiuyizhidedaoliaobaoliu。Flyme 4xuanfuqiushezhizuozudelidaixitong，junshicongpingmuxiacewangshanghuadonghuanchuhoutai。Flyme 3、Flyme 4weichoutishitubiaopailie，jiandanmingliao。zaiFlyme 5zhonghuanchengliaoshangxiahuadongkapianshihoutai，danyijianqinglifangzhizaipingmushangfang，bufangbiandanshoucaozuo，houlaiFlyme 6huanchengliaozuoyouhuadongkapianshihoutai，yijianqingliyenuodaoliaoxiafang。conghoutaidejinhualaishuo，Flymejingliliaoyoujiandankuaijiedaodazhonghuadezhiguanyubuyouhao，zaidaodazhonghuadezhiguanyuyouhaojiangudetuibian。｜Flyme 3Flyme 4 Flyme 5Flyme 6zaidangxiadeguochanshoujizhenyingzhong，zuozuzuoranyichengweirenjijiaohudeyinlingzhe，Flymegongbukemei。xitonggongnengyujiawanshan dandutezhichuyuelaiyueshaoxitonggongnengshang，Flymedefazhankeyiyonglianggecihuilaigaikuo——“chuancheng”he“biangeng”。“chuancheng”ziranshichuanchengFlymeteyoudegongneng。congFlyme 3kaishi，zuozudexitonggongnengjiuyijingbijiaowanbei，yongyouzijideyinlebofangqiheshipinbofangqi，nenggoumanzuyonghuduiyingyindexuqiu；zuozuzuolanqixiangyingsuduhenkuai，yizhiduyongyoubucuodewangyezuolanliuchangdu；bianqiankeyifangbianjiluwenbenhetupianxinxi，bingqiekeyiyunbeifen，jibianshuajiyekeyifangbianhuifushuju。Flyme 3zuozudeyunfuwuyizhiyongyoulianghaodetiyan，dengluflymezhanghaozhihou，yonghujiukeyiduilianxiren、tonghuajilu、duanxin、bianqian、zuolanqidengjinxingyunbeifen，zhiyaodengluflymezhanghao，shujujiukeyijinxinghuifu，fangbiankuaijie。zheyeshiFlymeyizhiyilaiyongyoujiaogaoyonghuzhanxingdeyuanyinzhiyi。Flyme 6zhongyuntongbugongnengjinyibuwanshan“biangeng”jiushigaibianyuanlaibubiyaodegongneng，zengjiaxingongneng。congFlyme 4kaishi，zuozuzaixitongzhongjiaruhenduoshiyongxingdegongneng——jiaruanquanzhongxin，yonghukeyitongguoanquanzhongxinduishoujijinxinggengshenyicengdeguanli；jiaruzixunyushenghuofuwu，rangxitongneirongyuelaiyuefengfu；dushuhegongjuxiangcongFlyme 5kaishibeijiarudaoxitongzhong，bingzaiFlyme 6zhongdedaoliaojinyibudewanshan。Flyme 6deanquanzhongxin、zixun、dushuduiyushuajidanglaishuo，meiyoushimebiyixiangwanshandebeifengongnenggengrangrenxingfendeliao。congFlyme 4kaishi，xitongneizhiliaobeifengongneng，yonghukeyiduilianxiren、duanxin、tonghuajilu、rili、xitongshezhi、yingyongjiyingyongshuju、xiangcejinxingshujubeifen，bingqiexinxitongshuahaohoukeyikuaisuduishujujinxinghuifu。Flyme 6jiangshujugongnengjinyibushenhua，jiaruliaohuanjizhushou，tongguohuanjizhushou，yonghukeyishixianxinjiushoujizhiqianshujudechuansong。Flyme 6shujubeifen、huanjizhushoumeiyibandeFlymeduhuidailaibushaoxinqidexiaogongneng，biruFlyme 5jiaruliaochangjietugongneng，Flyme 6youduigaigongnengjinyibuwanshan，yonghukeyiduijietujinxinggengduodezidingyishezhi；kapianshihoutaizaiFlyme 6shangbujinkeyishixiansuodinghefenping，huankeyiduihoutaikapianjinxingmohuchuli，baohuyonghudeyinsi；Flyme 6degongjuxianglibiFlyme 5duochufenbeiyi、yitouyingbichengxiandesuijishijianyijijibuqi。Flyme 6gongjuxiangcongFlyme 3kaishi，xitongneizhihuabanyingyong，yonghukeyiliyonghuabanjinxingtuyazuohua。zheyizhenduiwenyixiaoqingxindegongnengzaiqianjidaixitongzhongdeyibaoliu，danPRO 6 PlusdeFlyme 6quxiaoliaogaigongneng，buguoyonghukeyitongguozuozuyingyongshangdianxiazaidaozuozuhuaban。wuyi，zheyoushizuozumianduidaxiaoliangdetuoxiesuozai。zuoweiputongdexiaofeizhe，womenjibenshangbuhuiquzaiyishoujichangshangxuanchuandeshimezhinengyinqing，dazaishimehoutaiguanlimoshi，womenzhixuyaoguanxinxitongdaodikabuka，luojishifoujiandanheli，xitongdexiangyingsududaodikuaibukuaizheleizuizhijieqianxiandewenti。suoyiwomenhuigengjiazaiyiUIshejiyuxitongdeliuchangdu。xianran，jingguozhemeniandemolian，Flymezaizhexiefangmianyiranzuodaoliaorumusanfendechengdu。xianzaiguoneizhuliudeshoujicaozuoxitongduzhubuquyuwanshan，zuoweiyigeshoujixitonglaishuo，yijinghennanrangrenzaixiangdaoyoushimegongnengshitabuzhichide，jishiyou，yehenkuaijiunengbeikaifahuozhefuzhiguolai。suoyixianzaidezhuliucaozuoxitongzaigongnengshangyuelaiyuejiejinbingbushishimeqiguaideshiqing。Flymeyuelaiyuequjindazhonghua，conggongnengdejiaodulaishuozheyeshiqizhongyuanyinzhiyi。zongjie：Flymeweihehuiyouzheyangdetuibian？tongguozhemeduochanshu，xiangxinduzheyijingduizhegewentiyouliaoyidingliaojie，shuojiandanyixie，zuozutongguoxiaoermeideUIshejixiyindaoyipizhongshiyonghu，houlaizuozufaxianzhexieyonghushulianggenbenbuzuyirangzuozufazhanzhuangda，taxuyaogengduoderenqujieshoutademeixue，namejiubixurangqimeixuegengnengfuhedazhongdekouwei。zhiyuFlymedetuibiangeizuozudailailiaoshimehaochu，shuodaozhelidaanyexianeryijian——Flymejinruxiaofeizheshiyehounengbeikuaisujieshou，zuozuyeyincihuodegengguangdadeyonghuqunti。
快(碍耻补颈)乐(尝别)就(闯颈耻)在(窜补颈)当(顿补苍驳)下(齿颈补)
8，蹿补虫颈苍驳丑耻补苍箩颈别锄丑耻产补苍箩颈别蝉丑耻23产别颈蝉丑颈测颈苍驳濒惫虫颈补苍锄丑颈，蝉丑补苍驳蝉丑颈蝉丑辞耻飞耻谤颈飞耻锄丑补苍驳诲颈别蹿耻虫颈补苍锄丑颈，虫颈苍驳耻濒颈补苍虫耻测颈锄颈产补苍箩颈补苍驳产耻蹿耻肠耻苍锄补颈；锄丑耻产补苍蝉丑补苍驳蝉丑颈测颈锄丑辞耻丑辞耻锄丑补苍驳诲颈别蹿耻丑耻补苍蝉丑颈10%，濒耻别测颈飞补颈，20%迟颈苍驳丑补辞诲别；丑别箩颈补辞濒辞苍驳丑耻补苍迟颈诲补辞濒颈补辞测颈驳别飞别苍迟颈，苍补产颈补苍蝉丑颈“虫颈苍箩颈补苍驳苍辞苍驳肠丑补苍辫颈苍诲补箩颈补蝉丑颈飞别颈尘颈苍驳迟颈”。
药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)你(Ni)问(Wen)我(Wo)答(Da)系(Xi)列(Lie)（一(Yi)）2015-05-21 08:53·南(Nan)京(Jing)市(Shi)第(Di)一(Yi)医(Yi)院(Yuan)问(Wen)题(Ti)一(Yi)：何(He)谓(Wei)药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)？按(An)照(Zhao)WHO国(Guo)际(Ji)药(Yao)物(Wu)监(Jian)测(Ce)合(He)作(Zuo)中(Zhong)心(Xin)的(De)规(Gui)定(Ding)，药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)（adverse drug reactions,简(Jian)称(Cheng)ADR）系(Xi)指(Zhi)正(Zheng)常(Chang)剂(Ji)量(Liang)的(De)药(Yao)物(Wu)用(Yong)于(Yu)预(Yu)防(Fang)、诊(Zhen)断(Duan)、治(Zhi)疗(Liao)疾(Ji)病(Bing)或(Huo)调(Diao)节(Jie)生(Sheng)理(Li)机(Ji)能(Neng)时(Shi)出(Chu)现(Xian)的(De)有(You)害(Hai)的(De)和(He)与(Yu)用(Yong)药(Yao)目(Mu)的(De)无(Wu)关(Guan)的(De)反(Fan)应(Ying)。该(Gai)定(Ding)义(Yi)排(Pai)除(Chu)有(You)意(Yi)的(De)或(Huo)意(Yi)外(Wai)的(De)过(Guo)量(Liang)用(Yong)药(Yao)及(Ji)用(Yong)药(Yao)不(Bu)当(Dang)引(Yin)起(Qi)的(De)反(Fan)应(Ying)。我(Wo)国(Guo)是(Shi)WHO国(Guo)际(Ji)药(Yao)物(Wu)监(Jian)测(Ce)合(He)作(Zuo)计(Ji)划(Hua)的(De)成(Cheng)员(Yuan)国(Guo)，在(Zai)ADR监(Jian)测(Ce)工(Gong)作(Zuo)中(Zhong)应(Ying)遵(Zun)守(Shou)WHO所(Suo)规(Gui)定(Ding)的(De)ADR定(Ding)义(Yi)进(Jin)行(Xing)ADR报(Bao)告(Gao)。为(Wei)正(Zheng)确(Que)理(Li)解(Jie)WHO的(De)ADR定(Ding)义(Yi)，现(Xian)将(Jiang)原(Yuan)文(Wen)摘(Zhai)录(Lu)如(Ru)下(Xia)：A reaction which is noxious and unintended ,and which occurs at doses normally used in man for the prophylaxis, diagnosis, or therapy of diseases ,or for the modification of physiological function.This definition excludes accidental or deliberate excessive dosage or maladministration.问(Wen)题(Ti)二(Er)：药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)如(Ru)何(He)分(Fen)类(Lei)？药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)有(You)多(Duo)种(Zhong)分(Fen)类(Lei)方(Fang)法(Fa)，通(Tong)常(Chang)按(An)其(Qi)与(Yu)药(Yao)理(Li)作(Zuo)用(Yong)有(You)无(Wu)关(Guan)联(Lian)而(Er)分(Fen)为(Wei)两(Liang)类(Lei)：A型(Xing)和(He)B型(Xing)。A型(Xing)药(Yao)物(Wu)不(Bu)良(Liang)(Type A adverse drug reactions)又(You)称(Cheng)为(Wei)剂(Ji)量(Liang)相(Xiang)关(Guan)的(De)不(Bu)良(Liang)反(Fan)应(Ying)（dose-related adverse reactions）。该(Gai)反(Fan)应(Ying)为(Wei)药(Yao)理(Li)作(Zuo)用(Yong)增(Zeng)强(Qiang)所(Suo)致(Zhi)，常(Chang)和(He)剂(Ji)量(Liang)有(You)关(Guan)，可(Ke)以(Yi)预(Yu)测(Ce)，发(Fa)生(Sheng)率(Lv)高(Gao)而(Er)死(Si)亡(Wang)率(Lv)低(Di)，如(Ru)苯(Ben)二(Er)氮(Dan)zhuo类(Lei)引(Yin)起(Qi)的(De)瞌(Zuo)睡(Shui)，抗(Kang)血(Xue)凝(Ning)药(Yao)所(Suo)致(Zhi)出(Chu)血(Xue)等(Deng)。B型(Xing)药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)（Type B adverse drug reactions），又(You)称(Cheng)剂(Ji)量(Liang)不(Bu)相(Xiang)关(Guan)的(De)不(Bu)良(Liang)反(Fan)应(Ying)（non-dose-related adverse reactions）。它(Ta)是(Shi)一(Yi)种(Zhong)与(Yu)正(Zheng)常(Chang)药(Yao)理(Li)作(Zuo)用(Yong)无(Wu)关(Guan)的(De)异(Yi)常(Chang)反(Fan)应(Ying)，一(Yi)般(Ban)和(He)剂(Ji)量(Liang)无(Wu)关(Guan)联(Lian)，难(Nan)于(Yu)预(Yu)测(Ce)，发(Fa)生(Sheng)率(Lv)低(Di)（据(Ju)国(Guo)外(Wai)数(Shu)据(Ju)，占(Zhan)药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)的(De)20~25%）而(Er)死(Si)亡(Wang)率(Lv)高(Gao)，如(Ru)氟(Fu)烷(Wan)引(Yin)致(Zhi)的(De)恶(E)性(Xing)高(Gao)热(Re)，青(Qing)霉(Mei)素(Su)引(Yin)起(Qi)的(De)过(Guo)敏(Min)性(Xing)休(Xiu)克(Ke)。在(Zai)药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)中(Zhong)，副(Fu)作(Zuo)用(Yong)、毒(Du)性(Xing)反(Fan)应(Ying)、过(Guo)度(Du)效(Xiao)应(Ying)属(Shu)A型(Xing)不(Bu)良(Liang)反(Fan)应(Ying)。首(Shou)剂(Ji)效(Xiao)应(Ying)、撤(Che)药(Yao)反(Fan)应(Ying)、继(Ji)发(Fa)反(Fan)应(Ying)等(Deng)，由(You)于(Yu)与(Yu)药(Yao)理(Li)作(Zuo)用(Yong)有(You)关(Guan)也(Ye)属(Shu)A型(Xing)反(Fan)应(Ying)范(Fan)畴(Chou)。药(Yao)物(Wu)变(Bian)态(Tai)反(Fan)应(Ying)和(He)异(Yi)质(Zhi)反(Fan)应(Ying)属(Shu)B型(Xing)反(Fan)应(Ying)。问(Wen)题(Ti)三(San)：药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)的(De)发(Fa)生(Sheng)率(Lv)有(You)多(Duo)少(Shao)？据(Ju)国(Guo)外(Wai)有(You)关(Guan)文(Wen)献(Xian)报(Bao)道(Dao)，药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)的(De)发(Fa)生(Sheng)率(Lv)如(Ru)下(Xia)：（1）住(Zhu)院(Yuan)病(Bing)人(Ren)：10%~20%；（2）住(Zhu)院(Yuan)病(Bing)人(Ren)因(Yin)药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)死(Si)亡(Wang)者(Zhe)：0.24%~2.9%；（3）因(Yin)药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)而(Er)住(Zhu)院(Yuan)的(De)病(Bing)人(Ren)：0.3%~5.0%。问(Wen)题(Ti)四(Si)：药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)发(Fa)生(Sheng)频(Pin)率(Lv)通(Tong)常(Chang)如(Ru)何(He)表(Biao)示(Shi)？国(Guo)际(Ji)医(Yi)学(Xue)科(Ke)学(Xue)组(Zu)织(Zhi)委(Wei)员(Yuan)会(Hui)（Counsil for International Organization of Medical Sciences，简(Jian)称(Cheng)CIOMS）推(Tui)荐(Jian)用(Yong)下(Xia)列(Lie)术(Shu)语(Yu)和(He)百(Bai)分(Fen)率(Lv)表(Biao)示(Shi)药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)发(Fa)生(Sheng)频(Pin)率(Lv)：十(Shi)分(Fen)常(Chang)见(Jian)（≥10%），常(Chang)见(Jian)（≥1%，<10%），偶(Ou)见(Jian)（≥0.1%，<1%），罕(Han)见(Jian)（≥0.01%，<0.1%），十(Shi)分(Fen)罕(Han)见(Jian)（<0.01%）。问(Wen)题(Ti)五(Wu)：副(Fu)作(Zuo)用(Yong)是(Shi)否(Fou)为(Wei)不(Bu)良(Liang)反(Fan)应(Ying)的(De)同(Tong)义(Yi)词(Ci)？一(Yi)种(Zhong)药(Yao)物(Wu)常(Chang)有(You)多(Duo)种(Zhong)作(Zuo)用(Yong)，在(Zai)正(Zheng)常(Chang)剂(Ji)量(Liang)情(Qing)况(Kuang)下(Xia)出(Chu)现(Xian)与(Yu)用(Yong)药(Yao)目(Mu)的(De)无(Wu)关(Guan)的(De)反(Fan)应(Ying)称(Cheng)为(Wei)副(Fu)作(Zuo)用(Yong)（side effect）。一(Yi)般(Ban)说(Shuo)来(Lai)，副(Fu)作(Zuo)用(Yong)比(Bi)较(Jiao)轻(Qing)微(Wei)，多(Duo)为(Wei)可(Ke)逆(Ni)性(Xing)机(Ji)能(Neng)变(Bian)化(Hua)，停(Ting)药(Yao)后(Hou)通(Tong)常(Chang)很(Hen)快(Kuai)消(Xiao)退(Tui)。副(Fu)作(Zuo)用(Yong)随(Sui)用(Yong)药(Yao)目(Mu)的(De)不(Bu)同(Tong)而(Er)改(Gai)变(Bian)，如(Ru)阿(A)托(Tuo)品(Pin)作(Zuo)为(Wei)麻(Ma)醉(Zui)前(Qian)给(Gei)药(Yao)抑(Yi)制(Zhi)腺(Xian)体(Ti)分(Fen)泌(Mi)，则(Ze)术(Shu)后(Hou)肠(Chang)胀(Zhang)气(Qi)，尿(Niao)潴(Zuo)留(Liu)为(Wei)副(Fu)作(Zuo)用(Yong)，而(Er)当(Dang)阿(A)托(Tuo)品(Pin)用(Yong)于(Yu)解(Jie)除(Chu)胆(Dan)道(Dao)痉(Jing)挛(Luan)时(Shi)，心(Xin)悸(Ji)、口(Kou)干(Gan)成(Cheng)为(Wei)副(Fu)作(Zuo)用(Yong)。有(You)些(Xie)人(Ren)将(Jiang)副(Fu)作(Zuo)用(Yong)作(Zuo)为(Wei)不(Bu)良(Liang)反(Fan)应(Ying)的(De)同(Tong)义(Yi)词(Ci)，其(Qi)实(Shi)该(Gai)两(Liang)词(Ci)的(De)含(Han)义(Yi)不(Bu)尽(Jin)相(Xiang)同(Tong)，为(Wei)了(Liao)避(Bi)免(Mian)混(Hun)淆(Xiao)，WHO国(Guo)际(Ji)药(Yao)物(Wu)监(Jian)测(Ce)合(He)作(Zuo)中(Zhong)心(Xin)规(Gui)定(Ding)了(Liao)副(Fu)作(Zuo)用(Yong)的(De)定(Ding)义(Yi)，并(Bing)作(Zuo)了(Liao)说(Shuo)明(Ming)如(Ru)下(Xia)：Side Effect: Any unintended effect of a pharmaceutical product occuring at doses normally in man which is related to pharmacological properties of the drug.This is an old term and is broad enough to include both positive and negative effects of a drug apart from its main properties or indication. Some use the term as synonymos with adverse reactions, but the proposed definition will improve clarity of use of this term .问(Wen)题(Ti)六(Liu)：何(He)谓(Wei)毒(Du)性(Xing)反(Fan)应(Ying)？大(Da)多(Duo)数(Shu)药(Yao)物(Wu)都(Du)有(You)或(Huo)多(Duo)或(Huo)少(Shao)的(De)毒(Du)性(Xing)（toxicity）。毒(Du)性(Xing)反(Fan)应(Ying)（toxic reaction , toxic response）是(Shi)指(Zhi)药(Yao)物(Wu)引(Yin)起(Qi)肌(Ji)体(Ti)发(Fa)生(Sheng)生(Sheng)理(Li)生(Sheng)化(Hua)机(Ji)能(Neng)异(Yi)常(Chang)或(Huo)组(Zu)织(Zhi)结(Jie)构(Gou)病(Bing)理(Li)变(Bian)化(Hua)的(De)反(Fan)应(Ying)；该(Gai)反(Fan)应(Ying)可(Ke)在(Zai)各(Ge)个(Ge)系(Xi)统(Tong)、器(Qi)官(Guan)或(Huo)组(Zu)织(Zhi)出(Chu)现(Xian)。药(Yao)物(Wu)的(De)毒(Du)性(Xing)作(Zuo)用(Yong)（toxic effect）一(Yi)般(Ban)是(Shi)药(Yao)理(Li)作(Zuo)用(Yong)的(De)延(Yan)伸(Shen)，主(Zhu)要(Yao)对(Dui)神(Shen)经(Jing)、消(Xiao)化(Hua)、心(Xin)血(Xue)管(Guan)、泌(Mi)尿(Niao)、血(Xue)液(Ye)等(Deng)系(Xi)统(Tong)，以(Yi)及(Ji)皮(Pi)肤(Fu)组(Zu)织(Zhi)造(Zao)成(Cheng)损(Sun)害(Hai)。各(Ge)种(Zhong)药(Yao)物(Wu)毒(Du)性(Xing)性(Xing)质(Zhi)和(He)反(Fan)应(Ying)的(De)临(Lin)床(Chuang)表(Biao)现(Xian)各(Ge)相(Xiang)同(Tong)，但(Dan)反(Fan)应(Ying)程(Cheng)度(Du)和(He)剂(Ji)量(Liang)有(You)关(Guan)，剂(Ji)量(Liang)加(Jia)大(Da)，则(Ze)毒(Du)性(Xing)反(Fan)应(Ying)增(Zeng)强(Qiang)。药(Yao)物(Wu)引(Yin)致(Zhi)的(De)毒(Du)性(Xing)反(Fan)应(Ying)所(Suo)造(Zao)成(Cheng)的(De)持(Chi)续(Xu)性(Xing)的(De)功(Gong)能(Neng)障(Zhang)碍(Ai)或(Huo)器(Qi)质(Zhi)性(Xing)病(Bing)变(Bian)，停(Ting)药(Yao)后(Hou)恢(Hui)复(Fu)较(Jiao)慢(Man)，甚(Shen)至(Zhi)终(Zhong)身(Shen)不(Bu)愈(Yu)。如(Ru)氨(An)基(Ji)糖(Tang)苷(Zuo)类(Lei)抗(Kang)生(Sheng)素(Su)链(Lian)霉(Mei)素(Su)、庆(Qing)大(Da)霉(Mei)素(Su)等(Deng)具(Ju)有(You)耳(Er)毒(Du)性(Xing)（ototoxicity），可(Ke)引(Yin)致(Zhi)第(Di)八(Ba)对(Dui)颅(Lu)神(Shen)经(Jing)损(Sun)害(Hai)，造(Zao)成(Cheng)听(Ting)力(Li)减(Jian)退(Tui)或(Huo)永(Yong)久(Jiu)性(Xing)耳(Er)聋(Long)。问(Wen)题(Ti)七(Qi)：继(Ji)发(Fa)反(Fan)应(Ying)是(Shi)否(Fou)为(Wei)药(Yao)物(Wu)本(Ben)身(Shen)的(De)效(Xiao)应(Ying)？继(Ji)发(Fa)反(Fan)应(Ying)（secondary effect）并(Bing)不(Bu)是(Shi)药(Yao)物(Wu)本(Ben)身(Shen)的(De)效(Xiao)应(Ying)，而(Er)是(Shi)药(Yao)物(Wu)主(Zhu)要(Yao)作(Zuo)用(Yong)的(De)间(Jian)接(Jie)结(Jie)果(Guo)，如(Ru)广(Guang)谱(Pu)抗(Kang)生(Sheng)素(Su)长(Chang)期(Qi)应(Ying)用(Yong)可(Ke)改(Gai)变(Bian)正(Zheng)常(Chang)肠(Chang)道(Dao)菌(Jun)群(Qun)的(De)关(Guan)系(Xi)使(Shi)肠(Chang)道(Dao)菌(Jun)群(Qun)失(Shi)调(Diao)导(Dao)致(Zhi)二(Er)重(Zhong)感(Gan)染(Ran)（superinfection）；利(Li)尿(Niao)药(Yao)噻(Zuo)嗪(Zuo)类(Lei)引(Yin)起(Qi)的(De)低(Di)血(Xue)钾(Jia)可(Ke)以(Yi)使(Shi)患(Huan)者(Zhe)对(Dui)强(Qiang)心(Xin)药(Yao)地(Di)高(Gao)辛(Xin)不(Bu)耐(Nai)受(Shou)。青(Qing)霉(Mei)素(Su)类(Lei)引(Yin)致(Zhi)的(De)赫(He)氏(Shi)反(Fan)应(Ying)（Herxheimers reaction）也(Ye)属(Shu)于(Yu)继(Ji)发(Fa)反(Fan)应(Ying)。问(Wen)题(Ti)八(Ba)：如(Ru)何(He)预(Yu)防(Fang)首(Shou)剂(Ji)效(Xiao)应(Ying)？首(Shou)剂(Ji)效(Xiao)应(Ying)（first dose effect）又(You)称(Cheng)首(Shou)剂(Ji)综(Zong)合(He)征(Zheng)（syndrome of first dose）或(Huo)首(Shou)剂(Ji)现(Xian)象(Xiang)（first dose phenomenon），系(Xi)指(Zhi)一(Yi)些(Xie)病(Bing)人(Ren)在(Zai)初(Chu)服(Fu)某(Mou)种(Zhong)药(Yao)物(Wu)时(Shi)，由(You)于(Yu)肌(Ji)体(Ti)对(Dui)药(Yao)物(Wu)作(Zuo)用(Yong)尚(Shang)未(Wei)适(Shi)应(Ying)而(Er)引(Yin)起(Qi)不(Bu)可(Ke)耐(Nai)受(Shou)的(De)强(Qiang)烈(Lie)反(Fan)应(Ying)。最(Zui)初(Chu)发(Fa)现(Xian)引(Yin)起(Qi)首(Shou)剂(Ji)效(Xiao)应(Ying)的(De)药(Yao)物(Wu)为(Wei)α1受(Shou)体(Ti)阻(Zu)滞(Zhi)剂(Ji)哌(Zuo)唑(Zuo)嗪(Zuo)（prazoxin），该(Gai)药(Yao)引(Yin)起(Qi)的(De)首(Shou)剂(Ji)效(Xiao)应(Ying)表(Biao)现(Xian)为(Wei)恶(E)心(Xin)、头(Tou)晕(Yun)、头(Tou)痛(Tong)、心(Xin)悸(Ji)、嗜(Shi)睡(Shui)、体(Ti)位(Wei)性(Xing)低(Di)血(Xue)压(Ya)、休(Xiu)克(Ke)等(Deng)；β受(Shou)体(Ti)阻(Zu)滞(Zhi)剂(Ji)和(He)钙(Gai)拮(Zuo)抗(Kang)剂(Ji)也(Ye)可(Ke)引(Yin)起(Qi)首(Shou)剂(Ji)效(Xiao)应(Ying)。为(Wei)预(Yu)防(Fang)哌(Zuo)唑(Zuo)嗪(Zuo)的(De)首(Shou)剂(Ji)效(Xiao)应(Ying)，可(Ke)采(Cai)用(Yong)临(Lin)睡(Shui)前(Qian)给(Gei)药(Yao)，并(Bing)从(Cong)小(Xiao)剂(Ji)量(Liang)（0.5mg）开(Kai)始(Shi)；一(Yi)旦(Dan)发(Fa)生(Sheng)首(Shou)剂(Ji)效(Xiao)应(Ying)，应(Ying)使(Shi)患(Huan)者(Zhe)平(Ping)卧(Wo)，一(Yi)般(Ban)无(Wu)须(Xu)特(Te)殊(Shu)处(Chu)理(Li)。问(Wen)题(Ti)九(Jiu)：后(Hou)遗(Yi)效(Xiao)应(Ying)是(Shi)一(Yi)种(Zhong)暂(Zan)时(Shi)性(Xing)的(De)还(Huan)是(Shi)永(Yong)久(Jiu)性(Xing)的(De)效(Xiao)应(Ying)？后(Hou)遗(Yi)效(Xiao)应(Ying)（after effect）是(Shi)指(Zhi)停(Ting)药(Yao)后(Hou)血(Xue)浓(Nong)度(Du)已(Yi)降(Jiang)至(Zhi)阈(Zuo)浓(Nong)度(Du)以(Yi)下(Xia)时(Shi)残(Can)存(Cun)的(De)生(Sheng)物(Wu)效(Xiao)应(Ying)。后(Hou)遗(Yi)效(Xiao)应(Ying)可(Ke)能(Neng)比(Bi)较(Jiao)短(Duan)暂(Zan)，如(Ru)服(Fu)用(Yong)巴(Ba)比(Bi)妥(Tuo)类(Lei)催(Cui)眠(Mian)药(Yao)后(Hou)次(Ci)晨(Chen)的(De)宿(Su)醉(Zui)现(Xian)象(Xiang)；也(Ye)可(Ke)能(Neng)比(Bi)较(Jiao)持(Chi)久(Jiu)，如(Ru)长(Chang)期(Qi)应(Ying)用(Yong)肾(Shen)上(Shang)腺(Xian)皮(Pi)质(Zhi)激(Ji)素(Su)，一(Yi)旦(Dan)停(Ting)药(Yao)后(Hou)肾(Shen)上(Shang)腺(Xian)皮(Pi)质(Zhi)功(Gong)能(Neng)低(Di)下(Xia)，数(Shu)月(Yue)内(Nei)难(Nan)以(Yi)恢(Hui)复(Fu)。少(Shao)数(Shu)药(Yao)物(Wu)可(Ke)以(Yi)导(Dao)致(Zhi)永(Yong)久(Jiu)性(Xing)器(Qi)质(Zhi)性(Xing)损(Sun)害(Hai)，如(Ru)链(Lian)霉(Mei)素(Su)引(Yin)起(Qi)永(Yong)久(Jiu)性(Xing)耳(Er)聋(Long)。问(Wen)题(Ti)十(Shi)：何(He)谓(Wei)ADE？ADE是(Shi)adverse drug event的(De)缩(Suo)写(Xie)，即(Ji)药(Yao)物(Wu)不(Bu)良(Liang)事(Shi)件(Jian)。药(Yao)物(Wu)不(Bu)良(Liang)事(Shi)件(Jian)与(Yu)不(Bu)良(Liang)反(Fan)应(Ying)的(De)含(Han)义(Yi)有(You)所(Suo)不(Bu)同(Tong)。不(Bu)良(Liang)事(Shi)件(Jian)是(Shi)指(Zhi)在(Zai)药(Yao)物(Wu)治(Zhi)疗(Liao)过(Guo)程(Cheng)中(Zhong)出(Chu)现(Xian)的(De)不(Bu)利(Li)的(De)临(Lin)床(Chuang)事(Shi)件(Jian)，但(Dan)该(Gai)事(Shi)件(Jian)未(Wei)必(Bi)与(Yu)药(Yao)物(Wu)有(You)因(Yin)果(Guo)关(Guan)系(Xi)。不(Bu)良(Liang)事(Shi)件(Jian)也(Ye)可(Ke)理(Li)解(Jie)为(Wei)new clinical incidents and/or adverse reactions，即(Ji)它(Ta)包(Bao)含(Han)临(Lin)床(Chuang)新(Xin)出(Chu)现(Xian)的(De)偶(Ou)然(Ran)事(Shi)件(Jian)及(Ji)不(Bu)良(Liang)反(Fan)应(Ying)，例(Li)如(Ru)在(Zai)使(Shi)用(Yong)某(Mou)种(Zhong)药(Yao)物(Wu)期(Qi)间(Jian)出(Chu)现(Xian)的(De)病(Bing)情(Qing)的(De)恶(E)化(Hua)，并(Bing)发(Fa)症(Zheng)，就(Jiu)诊(Zhen)或(Huo)住(Zhu)院(Yuan)，化(Hua)验(Yan)结(Jie)果(Guo)异(Yi)常(Chang)，各(Ge)种(Zhong)原(Yuan)因(Yin)的(De)死(Si)亡(Wang)，各(Ge)种(Zhong)事(Shi)故(Gu)如(Ru)骨(Gu)折(Zhe)、车(Che)祸(Huo)，或(Huo)导(Dao)致(Zhi)这(Zhe)些(Xie)事(Shi)故(Gu)的(De)原(Yuan)因(Yin)--瞌(Zuo)睡(Shui)、眩(Xuan)晕(Yun)、晕(Yun)厥(Zuo)、视(Shi)力(Li)障(Zhang)碍(Ai)等(Deng)，以(Yi)及(Ji)可(Ke)疑(Yi)的(De)药(Yao)物(Wu)不(Bu)良(Liang)反(Fan)应(Ying)。ADE是(Shi)否(Fou)确(Que)为(Wei)药(Yao)物(Wu)所(Suo)致(Zhi)须(Xu)经(Jing)分(Fen)析(Xi)评(Ping)估(Gu)。为(Wei)正(Zheng)确(Que)理(Li)解(Jie)ADE的(De)含(Han)义(Yi)，现(Xian)将(Jiang)WHO国(Guo)际(Ji)药(Yao)物(Wu)监(Jian)测(Ce)合(He)作(Zuo)中(Zhong)心(Xin)规(Gui)定(Ding)的(De)不(Bu)良(Liang)事(Shi)件(Jian)定(Ding)义(Yi)抄(Chao)录(Lu)如(Ru)下(Xia)：Any untoward medical occurrence that may present during treatment with a pharmaceutical product but which does not necessarily have a causal relationship with this treatment.
李宇嘉表示，央行降低1年期MLF，预计5年期LPR有望下降，有望对后市形成一定支撑。但最关键的还是需求端对新市民、年轻人的就业、收入能积极帮助，供给端对开发商的风险能及时控制，否则金融层面的降息政策难以支撑地产量价的稳定。如果是坐高铁，可以在丽水站下车，租车或者包车到云和梯田。欧洲一卡二卡叁乱码新区据说加入了一键选择功能,平台表示:支持...
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