站长工具 - 91 免费国产永久入口-91中文字幕-人人视频...
我母亲的娘家就在花桥镇的寿字阁村。小时候，我常跟着母亲到外婆家去玩，被那里的绿水青山深深吸引。那时候，我总是盼望着去外婆家，盼着坐汽车，而且我特别爱闻汽车散发的汽油味，闻着汽油味去外婆家总是令我兴奋不已。
2025年01月01日，在《星光大道》爆红的第二年。
站长工具 - 91 免费国产永久入口-91中文字幕-人人视频...
遇到机票跳水到底能不能免费退票东航这样说
2024-07-05 11:32·中国新闻周刊纳德拉称：“虽然我非常尊重埃隆(马斯克)和他所做的一切，但我只想说这实际上是不正确的，OpenAI非常重视由非营利组织控制。微软在其中拥有非控股权益。”
锄补颈尘补辞办补诲补驳辞苍驳，肠丑耻辩耻蝉丑别产补辞诲别丑耻补，诲补辞蝉丑辞耻虫颈苍锄颈蝉补苍辩颈补苍办耻补颈诲耻产耻诲补辞，苍补蝉丑颈飞辞蝉丑别苍锄丑颈虫颈补苍驳驳耻辞办别测颈辩耻诲辞苍驳飞耻测耻补苍诲补苍驳驳耻补苍濒颈测耻补苍。锄丑别锄丑颈丑别颈蝉别尘补苍箩颈办补苍驳补颈箩颈补辞尘补辞，蝉丑颈测颈驳别虫颈补辞苍惫丑补颈，箩颈耻蝉丑颈飞辞肠辞苍驳尘补辞办补诲补颈丑耻颈濒补颈诲别，蝉补苍驳别测耻别诲别驳辞苍驳锄颈箩颈耻丑耻补苍丑耻颈濒颈补辞迟补。迟补诲补苍虫颈补辞测辞耻锄耻辞谤别苍，蝉耻补苍蝉丑颈飞辞箩颈补蹿别颈肠丑补苍驳飞别苍箩颈苍驳诲别测颈驳别丑补颈锄颈。驳耻辞测辞耻濒颈耻诲补虫颈苍驳驳辞苍驳驳补辞虫颈补苍蝉丑颈，锄颈6测耻别8谤颈辩颈，丑耻辞辩颈肠耻苍办耻补苍驳耻补辫补颈濒颈濒惫肠辞苍驳肠颈辩颈补苍诲别0.25%虫颈补诲颈补辞锄丑颈0.2%，2苍颈补苍辩颈诲颈苍驳辩颈肠耻苍办耻补苍驳耻补辫补颈濒颈濒惫虫颈补诲颈补辞10驳别箩颈诲颈补苍锄丑颈2.05%，3苍颈补苍辩颈诲颈苍驳肠耻苍驳耻补辫补颈濒颈濒惫虫颈补诲颈补辞15驳别箩颈诲颈补苍锄丑颈2.45%，5苍颈补苍诲颈苍驳辩颈肠耻苍办耻补苍驳耻补辫补颈濒颈濒惫虫颈补诲颈补辞15驳别箩颈诲颈补苍锄丑颈2.5%。肠颈飞补颈，锄丑补辞蝉丑补苍驳测颈苍虫颈苍驳、辫颈苍驳补苍测颈苍虫颈苍驳、锄丑辞苍驳虫颈苍测颈苍虫颈苍驳、辫耻蹿补测颈苍虫颈苍驳、驳耻补苍驳诲补测颈苍虫颈苍驳、锄丑别蝉丑补苍驳测颈苍虫颈苍驳诲别苍驳诲耻辞箩颈补驳耻蹿别苍锄丑颈测颈苍虫颈苍驳测颈箩颈产耻蹿别苍肠丑别苍驳蝉丑补苍驳虫颈苍驳、苍辞苍驳蝉丑补苍驳虫颈苍驳测别驳别苍蝉耻颈虫颈补诲颈补辞肠耻苍办耻补苍驳耻补辫补颈濒颈濒惫。
报(Bao)告(Gao)称(Cheng)中(Zhong)国(Guo)民(Min)宿(Su)行(Xing)业(Ye)迎(Ying)丰(Feng)年(Nian) 热(Re)门(Men)城(Cheng)市(Shi)预(Yu)订(Ding)量(Liang)倍(Bei)增(Zeng)2023-12-19 20:51·中(Zhong)国(Guo)新(Xin)闻(Wen)网(Wang)中(Zhong)新(Xin)社(She)北(Bei)京(Jing)12月(Yue)19日(Ri)电(Dian) （记(Ji)者(Zhe) 刘(Liu)亮(Liang)）今(Jin)年(Nian)中(Zhong)国(Guo)民(Min)宿(Su)行(Xing)业(Ye)迎(Ying)来(Lai)“丰(Feng)收(Shou)年(Nian)”。途(Tu)家(Jia)民(Min)宿(Su)预(Yu)订(Ding)平(Ping)台(Tai)19日(Ri)发(Fa)布(Bu)的(De)《2023年(Nian)民(Min)宿(Su)行(Xing)业(Ye)发(Fa)展(Zhan)观(Guan)察(Cha)》报(Bao)告(Gao)显(Xian)示(Shi)，2023年(Nian)平(Ping)台(Tai)上(Shang)热(Re)门(Men)城(Cheng)市(Shi)预(Yu)订(Ding)量(Liang)比(Bi)疫(Yi)情(Qing)前(Qian)的(De)2019年(Nian)增(Zeng)长(Chang)1.2倍(Bei)。与(Yu)此(Ci)同(Tong)时(Shi)，民(Min)宿(Su)房(Fang)东(Dong)队(Dui)伍(Wu)明(Ming)显(Xian)扩(Kuo)列(Lie)。从(Cong)民(Min)宿(Su)预(Yu)订(Ding)热(Re)门(Men)城(Cheng)市(Shi)看(Kan)，报(Bao)告(Gao)显(Xian)示(Shi)，前(Qian)十(Shi)大(Da)热(Re)门(Men)城(Cheng)市(Shi)为(Wei)成(Cheng)都(Du)、重(Zhong)庆(Qing)、北(Bei)京(Jing)、上(Shang)海(Hai)、大(Da)理(Li)、广(Guang)州(Zhou)、青(Qing)岛(Dao)、西(Xi)安(An)、长(Chang)沙(Sha)和(He)杭(Hang)州(Zhou)。从(Cong)预(Yu)订(Ding)量(Liang)增(Zeng)速(Su)排(Pai)名(Ming)看(Kan)，那(Na)曲(Qu)、和(He)田(Tian)、昌(Chang)都(Du)、日(Ri)喀(Ka)则(Ze)、山(Shan)南(Nan)、博(Bo)尔(Er)塔(Ta)拉(La)、喀(Ka)什(Shi)等(Deng)城(Cheng)市(Shi)增(Zeng)速(Su)居(Ju)前(Qian)。从(Cong)消(Xiao)费(Fei)者(Zhe)习(Xi)惯(Guan)看(Kan)，“90后(Hou)”最(Zui)爱(Ai)住(Zhu)民(Min)宿(Su)，预(Yu)订(Ding)量(Liang)最(Zui)高(Gao)；“80后(Hou)”最(Zui)舍(She)得(De)花(Hua)钱(Qian)，预(Yu)订(Ding)间(Jian)夜(Ye)价(Jia)格(Ge)最(Zui)高(Gao)；“00后(Hou)”最(Zui)“特(Te)种(Zhong)兵(Bing)”，在(Zai)同(Tong)一(Yi)目(Mu)的(De)地(Di)城(Cheng)市(Shi)中(Zhong)换(Huan)住(Zhu)民(Min)宿(Su)数(Shu)量(Liang)最(Zui)多(Duo)，平(Ping)均(Jun)每(Mei)间(Jian)民(Min)宿(Su)停(Ting)留(Liu)1.52天(Tian)。从(Cong)房(Fang)型(Xing)选(Xuan)择(Ze)上(Shang)看(Kan)，携(Xie)家(Jia)带(Dai)口(Kou)、朋(Peng)友(You)聚(Ju)会(Hui)型(Xing)的(De)消(Xiao)费(Fei)者(Zhe)最(Zui)爱(Ai)住(Zhu)民(Min)宿(Su)，且(Qie)更(Geng)喜(Xi)欢(Huan)整(Zheng)院(Yuan)、多(Duo)居(Ju)民(Min)宿(Su)，其(Qi)预(Yu)订(Ding)量(Liang)比(Bi)2019年(Nian)增(Zeng)长(Chang)2倍(Bei)。此(Ci)外(Wai)，平(Ping)台(Tai)上(Shang)带(Dai)有(You)私(Si)家(Jia)花(Hua)园(Yuan)、陶(Tao)艺(Yi)手(Shou)工(Gong)、赶(Gan)海(Hai)、种(Zhong)植(Zhi)体(Ti)验(Yan)等(Deng)标(Biao)签(Qian)的(De)民(Min)宿(Su)预(Yu)订(Ding)量(Liang)也(Ye)出(Chu)现(Xian)较(Jiao)大(Da)幅(Fu)度(Du)增(Zeng)长(Chang)。更(Geng)多(Duo)人(Ren)加(Jia)入(Ru)到(Dao)民(Min)宿(Su)房(Fang)东(Dong)行(Xing)列(Lie)中(Zhong)。2023年(Nian)新(Xin)房(Fang)东(Dong)数(Shu)量(Liang)比(Bi)2019年(Nian)增(Zeng)长(Chang)77%。“90后(Hou)”“00后(Hou)”接(Jie)棒(Bang)成(Cheng)为(Wei)房(Fang)东(Dong)主(Zhu)力(Li)，在(Zai)今(Jin)年(Nian)新(Xin)增(Zeng)房(Fang)东(Dong)中(Zhong)占(Zhan)比(Bi)超(Chao)四(Si)成(Cheng)。今(Jin)年(Nian)小(Xiao)众(Zhong)爆(Bao)火(Huo)的(De)目(Mu)的(De)地(Di)和(He)传(Chuan)统(Tong)热(Re)门(Men)城(Cheng)市(Shi)新(Xin)增(Zeng)房(Fang)东(Dong)最(Zui)多(Duo)，如(Ru)因(Yin)朝(Chao)鲜(Xian)族(Zu)风(Feng)情(Qing)而(Er)爆(Bao)火(Huo)的(De)旅(Lv)行(Xing)目(Mu)的(De)地(Di)——延(Yan)边(Bian)，排(Pai)名(Ming)第(Di)一(Yi)。传(Chuan)统(Tong)热(Re)门(Men)目(Mu)的(De)地(Di)，如(Ru)哈(Ha)尔(Er)滨(Bin)市(Shi)、重(Zhong)庆(Qing)市(Shi)、洛(Luo)阳(Yang)市(Shi)、西(Xi)安(An)市(Shi)紧(Jin)随(Sui)其(Qi)后(Hou)。报(Bao)告(Gao)还(Huan)显(Xian)示(Shi)，目(Mu)前(Qian)平(Ping)台(Tai)超(Chao)六(Liu)成(Cheng)的(De)房(Fang)东(Dong)是(Shi)“斜(Xie)杠(Gang)房(Fang)东(Dong)”，即(Ji)兼(Jian)职(Zhi)经(Jing)营(Ying)民(Min)宿(Su)。房(Fang)东(Dong)中(Zhong)，经(Jing)营(Ying)1至(Zhi)2套(Tao)民(Min)宿(Su)的(De)人(Ren)最(Zui)多(Duo)，占(Zhan)比(Bi)超(Chao)过(Guo)一(Yi)半(Ban)。房(Fang)东(Dong)职(Zhi)业(Ye)中(Zhong)，餐(Can)饮(Yin)和(He)住(Zhu)宿(Su)占(Zhan)比(Bi)最(Zui)高(Gao)，达(Da)20%。文(Wen)化(Hua)体(Ti)育(Yu)、建(Jian)筑(Zhu)、互(Hu)联(Lian)网(Wang)、教(Jiao)育(Yu)的(De)从(Cong)业(Ye)者(Zhe)分(Fen)列(Lie)其(Qi)后(Hou)。在(Zai)迎(Ying)来(Lai)“丰(Feng)收(Shou)年(Nian)”的(De)同(Tong)时(Shi)，今(Jin)年(Nian)以(Yi)来(Lai)民(Min)宿(Su)业(Ye)也(Ye)暴(Bao)露(Lu)出(Chu)不(Bu)少(Shao)问(Wen)题(Ti)，如(Ru)到(Dao)店(Dian)无(Wu)房(Fang)、民(Min)宿(Su)滤(Lv)镜(Jing)化(Hua)严(Yan)重(Zhong)、服(Fu)务(Wu)体(Ti)验(Yan)差(Cha)等(Deng)。中(Zhong)国(Guo)社(She)会(Hui)科(Ke)学(Xue)院(Yuan)财(Cai)经(Jing)战(Zhan)略(Lue)研(Yan)究(Jiu)院(Yuan)博(Bo)士(Shi)后(Hou)、长(Chang)期(Qi)专(Zhuan)注(Zhu)民(Min)宿(Su)旅(Lv)游(You)研(Yan)究(Jiu)的(De)龙(Long)飞(Fei)认(Ren)为(Wei)，长(Chang)期(Qi)看(Kan)，这(Zhe)些(Xie)问(Wen)题(Ti)需(Xu)企(Qi)业(Ye)、行(Xing)业(Ye)、监(Jian)管(Guan)层(Ceng)面(Mian)共(Gong)同(Tong)发(Fa)力(Li)解(Jie)决(Jue)。（完(Wan)）
ertonglinbamuxibaolinbaliuzhenliaoguifan（2019 nianban）2019-10-28 16:25·zhongliujie2022yi、gaishulinbamuxibaolinbaliu(lymphoblastic lymphoma, LBL)shiyizuqiyuanyubuchengshuqianti T huo B linbaxibaodeexingzhongliu，yuezhanertongfeihuoqijinlinbaliu（Non Hodgkin Lymphoma, NHL）de 35%～40%，shiertong NHL zuichangjiandebinglileixingzhiyi。youyu LBL yujixinglinbaxibaobaixuebing（acute lymphocytic leukemia, ALL）juyouxiangsidelinchuangheshiyanshitezheng，zhexietezhengbaokuoxibaoxingtaixue、mianyibiaoxing、jiyinxing、xibaoyichuanxueyijilinchuangbiaoxianheyuhou，yincidangqian WHO fenleijiangerzhegongtongguiyuqiantilinbaxibaozhongliu，mingmingweiqianti T/B linbamuxibaobaixuebing/linbaliu（T/B-ALL/LBL）。danglinchuangyizhongliuxingbingzaoqibingerwugusuijiwaizhouxuejinrunhuogusuizhongzhongliuxinglinbamuxibaoxiaoyu25%shizhenwei LBL；dangyougusuihewaizhouxueshoulei，gusuizhonglinbamuxibaodayu 25%shi，zezhenwei ALL。anzhaomianyibiaoxingfenwei T xibaoxing（yuezhan70%～80%）he B xibaoxing（yuezhan 20%～30%）。jinnianlai，tongguocaiyongyuweixianduxiangguandeleisizhiliao ALL defanganhualiao，shiliaoxiaodedaoxianzhutigao，yixiezhiliaozhongxin 5 nianwushijianshengcunlv（Event-free survival，EFS）yidadao 75%～90%。er、shiyongfanweiyijuhuanerlinchuangtedian，jingzhongwuhuojian、xiongfushuihuogusuixibaoxingtaixue、mianyibiaoxing、xibaoyichuanxuehefenzishengwuxuejiancequezhen，bingjingzhishaoliangjiasanjijiadengyiyuanbinglizhuanjiahuizhenjieguoyizhi，an WHO 2016linbaxitongzhongliubinglizhenduanfenxingbiaozhunjinxingzhenduanhefenxingdeertongheqingshaonian LBL。san、zhenduan（yi）linchuangbiaoxian1.qianti T linbamuxibaolinbaliu（T-LBL）：qian T xibaozhongliu85%～90%biaoxianwei LBL，shaoshubiaoxianwei ALL。haofayunianchanger，zhongweifabingnianling 9-12 sui。nanxingduojian，nannvzhibi（2.5～3）:1。dianxingdelinchuangbiaoxianweiqianzongzuozhongwu，chuxianqingzhongbudengdeqidaoyapozhengzhuangrukesu、xiongmen、chuanxi、qicu、duanzuohuxideng，banxiongmoqinfankehebingxiongqiangjiye，jiazhonghuxikunnan；zongzuozhongwuyaposhiguankeyinqitunyankunnan；yaposhangqiangjingmaikezhijingmaihuiliushouzu、jingmianbuheshangzhishuizhong，ji"shangqiangjingmaizonghezheng（superior vena cava syndrome）"；qinfanxinbao，kedaozhiexingdexinbaojiyehexinbaotiansai。linbajiebingbianyuezhan 70%，yijingbu、suogushangheyexiaduojian。bufenhuanzhehebingganpizhongda。yue 50%gusuishoulei；yue 15%zhongshushenjingxitongzhuanyi，naomobingbianduoyunaoshizhibingbian；xingxianshouleiyuezhan 5%。benbingwangwangjinzhanxunsu，90%yishangbinglijiuzhenshiyichuyulinchuangⅢ、Ⅳqi。2.qianti B linbamuxibaolinbaliu(B-LBL)：yuqianti T xibaozhongliuxiangfan，qian B xibaogouchengdezhongliu 85%yishangbiaoxianwei ALL，zhiyou 10%～20%wei LBL。B-LBL fabingnianlingjiaoxiao，zhongweinianlingxiaoyu 6 sui。fabingwumingxianxingbietezheng。changjianbiaoxianweilinbajiezhongdajipifu、ruanzuzhi(youqishitoujingbu)、gu（changjianyugugu、zuogu、jizhugu）dengjiewaiqinfan，biaoxianweipifuduofaxinghongsejiejie，guneigulixingzhongkuai，yingxiangxuejianchashirongguxinghuoyinghuaxingbingbian；shaojiandebiaoxianyouzongzuo、xiongmoqinfan，neizangqinfanrushenzang、xiaohuadaojinrundeng。yeyifashenggusuihe CNS jinrun。（er）shiyanshijiancha1.binglijiancha：suoyoubingrenjunxutongguozhongliuzuzhihuogusuibinglihuojianquezhen。（1）binglixingtaixue：linbajiejiegoupohuai，zhongliuchangqinfanlinbajiebaomo、jiewaizhifanghexianweizuzhi。liuxibaochengmimanxingzhimidexiangduidanyixingjinrunshengchang，xibaozhongdengdaxiao，hezhibigao，heyuanxing、luanyuanxinghuoquxinghe，ransezhixirufenchen，herenchangbumingxian，baozhixishaodanran，hefenliexiangduojian。xibaoxuetezhengyu FAB fenxingzhongde L1 huo L2 xingyouzhilinbaxibaoxiangduiying。liuxibaojianhenshaoyouqitafanyingxingxibaochengfen，bufenbinglikejian"xingkongxianxiang"。（2）mianyibiaoxing：①linbamuxibaodebiaozhi：baokuo TdT、CD99、CD34、CD1a。LBL laiyuanyuqiantide T huo B linbaxibao，TdT beirenweishiqiantilinbaxibaodetezhengxingbiaozhi，xiongxianhuogusuiqian T、qian B xibaojunkechengxianyangxingbiaoda，wenxianbaodaoqiyangxinglvkeda 90%～95%。CD99 yebeirenweishiqianT xibaodelianghaobiaojiwu，dantabujinbiaodayurendexiongxianpizhixibaoyiji ALL/LBL xibaozhong，zai Ewing's rouliu（ES）、yuanshishenjingwaipeiyezhongliu（PNET）yijixiongxianliuzhongyejunyouyangxingbiaoda，yincizaijianbiezhenduanshangbixupeiyixiangyingdeqitayouxiaobiaozhilianheguancha。②T-LBL fashengyuxiongxianzuzhi，zhongliuxibaolaiyuanyuqianxiongxianxibao、xiongxianxibao，biaoda CD3、CD2、CD5、CD7，CD7 shiqiteyixingkangyuan。muqianrenwei T-LBL laiyuanyuxiongxianzhongfayuxiangduichengshudeqianti T xibao，er T-ALL jiaozhiyougengzaoqidefenhuajieduan。COG baogaoliao 180 li T-LBLdemianyibiaoxingtezhengyu T-ALL xiangsi，dan CD4/CD8 shuangyangxingdefashenglvmingxiangaoyuhouzhe，yezhichi T-LBL juyougengchengshumianyibiaoxing。③B-LBL zhongliuxibaolaiyuanyugusui，shuyuqianqian B、qian B、putongB jieduan，biaoda CD10、CD19、CD20、CD22、CD79a，qizhong CD79awei B xibaoteyixingkangyuan。Mayer dengbaodao 22%B-LBL cunzaimianyiqiudanbaiγqingliandequeshi，erzai B-ALL zhongdefashenglvjinwei 1%，yetishiliaoB-LBL laiyuanyujiao B-ALL shaochengshujieduandeqianti B xibao。④zaoqian T linbaxibaobaixuebing/linbaliu（ETP-ALL/LBL）：qiyuanyuzuichufenhuajieduandexiongxianxibao，juyouxiang T xi、suixi、shutuzhuangxibao、NK xibaofenhuadeqianneng，mianyifenxingtedian：quefa CD1a、CD4、CD8 debiaoda；CD5 ruobiaodahuozhebubiaoda；zhishaoyouyigesuixihuoganxibaoxiangguandekangyuanbiaoda（CD13、CD33、CD117、CD11b、CD34、HLA-DRdeng）；biaoda CD7、CD2、CD3 deng T xibaobiaozhi。yuezhan T-ALL/LBLde 10%～15%。benxingyuhoujiaocha。2.xibaoyichuanxue（Cytogenetics）hefenzishengwuxue（Molecular biology）benbingyuduozhongjiyinyichangyouguan，baokuokangyuanshoutijiyin、ransetiyichang、yiaijiyinshihuoyijiaijiyindejihuodeng。tongguoransetihexingfenxi、FISH fangfa、ronghejiyindingliang RT-PCR、IgH/TCR zhongpaijiance、xinyidaicexu（NGS）defangfajinxingxiangguanjiancha。95%yishang T-ALL/LBL you T xibaoshouti(T cell receptor,TCR)jiyinkelongxingzhongpai，daduoshu T-ALL biaoxianweifenhuachengshuguochengzhongshouxianzhongpaide TCRγσlianjiyin，er T-LBL zeduoweiαβlianjiyinzhongpai，yetishiliao T-ALL defenhuajieduanzaoyu T-LBL。dayue 20％T-ALL/LBL tongshiyou IgH jiyinzhongpai。juedaduoshu B-LBL you Ig-H jiyinzhongpai，yekeyou Ig-L jiyinzhongpai。50％～70％de T-ALL/LBL youransetihexingyichang。daduoshuhexingyichangyufeisuijixingduandianyouguan：changleiji TCRασ（14q11.2），β（7q35），γ（7q14-15），baokuocharutubian、queshiyijiransetiyiwei。yiweitongchangshiyuanaijiyinjihuobingyichangbiaoda，daozhiyuxibaozhouqidiaokonghexibaofenhuaxiangguandebajiyinjihuoerzhizhongliu。xianyizhiyuT-ALL/LBL fabingyouguandezhongyaoyuanaijiyinyou T xibaojixingbaixuebingjiyin 1(TAL-1)/SCL、HOX11、HOX11L2、LYL1、LMO1 he LMO2 deng。del（9p）queshidaozhideyiaijiyin CDKN2A dediushiyeshibenbingfashengdejizhizhiyi。muqianyizhijuyoujihuotubianleijibianmaqian T xibaofayudeguanjiandanbaideNOTCH1jiyindebingrenyuhoulianghao，fashenglvyuewei50%；eryue 10%debingrenjuyouranseti 6q zahexingqueshi（Loss of heterozygosity at chromosome 6q；LOH6q），qifufafengxianzenggao，yuhoubuliang。yue 60% B-ALL/LBL youtezhengxingyichuanxuegaibianqiejuyouzhongyaodelinchuangzhenduanheyuhoupanduanyiyi。yichuanxueshangtishiyuhoujiaohaodeyouchaoerbeiti(ransetishu＞50)hexingji t(12;21)(p12;q22）yiweixingchengTEL/AML1 ronghejiyin；eryaerbeiti(ransetishuxiaoyu 45)、t（9;22）(q34;q11.2)xingcheng BCR/ABLl、 t（ 4;11 ）huo MLL/AF4 、 t（1;19)(q23;13.3)xingchengde(E2A-PBX1; TCF3/PBX1)yiji Phyangjiyinhuotubiandengyulinchuangliaoxiaobujia、yuhoubuliangxiangguan。3.xuechanggui：baixibaokezhengchanghuoqingdushenggao，keyoupinxue，duoweizhengxibaozhengsesuxingpinxue。danggusuishouleishi，keyoubaixibaozongshushenggaohuojiandi，waizhouxuechuxianyouzhixibao，kebanyoupinxuehe/huoxuexiaobanjiandi。4.xueshenghua：ganshengongneng、rusuantuoqingmei（LDH）、dianjiezhishibichaxiangmu。wangwangbiaoxianweiniaosuan、rusuantuoqingmeizenggao，zheliangxiangzhibiaoduijibinghuanjieqingkuangjiyuhouyoutishizuoyong。5.ningxuegongneng：baokuo PT、APTT、TT、FIB、D erjuti、FDP。benbingkezaochengningxuegongnengyichang，ningxuemeiyuanhexianweidanbaiyuanjianshao，congerdaozhiningxuemeiyuanshijianyanchanghechuxue。6.gusuijiancha：gusuishouleishi，gusuizhongyouzhilinbaxibaoyibanxiaoyu 25%，tongguoliushixibaoshu、xibaoyichuanxue、jiyinzhongpaidengjianchayouzhuyuzhenduanhefenxing。liushixibaoyijiancekeyifaxianyinxingdegusuishoulei。gusuihuojianduigusuiqinfandejianchulvgaoyugusuixingtaixue。7.naojiyejiancha：changguixingnaojiyechanggui、shenghua、shuaipianzhaozhongliuxibaoliaojieyouwuzhongshushenjingxitong（Central nervous system, CNS）deqinfan。liushixibaoyijiancezhongliuxibaomianyifenxingketigao CNS qinfanjianchulv。8.yingxiangxuejiancha：zhiliaoqianxuchangguijinxingquanshenyingxiangxuejianchayimingqueshouleibuwei，xiezhufenqi。X xianjiancha：gupian（yougu、guanjiezhongtongzhe）；B chao：zhishaobaokuojingbulinbajie B chao、fubu B chaojibingzaobuweixiangguan B chao（zuozuidaliuzaoceliang）；CT：zhishaobaokuoxiongfupen CT pingsao（ruozuo PET/CT，kebuzuochanggui CT jiancha，jinzuobingzaobuweijiancha）；bingzaobuweixuxingzengqiang CT jiancha；huaiyizhongshushenjingxitongbingbiandexingtouluhe（huo）jisui MRI jiancha；youtiaojianzhejinkenengxingquanshen PET/CT jiancha。（san）ertong LBL dezhenduanbiaozhun1.zhenduanbiaozhunWHO 2016youguanlinbazaoxuezuzhizhongliufenleizhongguidingliaoLBLdezhenduanbiaozhun。chuyijuhuanzhelinchuangtedianwai，junxujingguoshouleizuzhihuojian，jinxingzuzhibinglixue、mianyibiaoxing、xibaoyichuanxuehefenzishengwuxuedejiancequezhen。linchuangfenqi：genjuquanshenyingxiangxue、naojiyejigusuidengjiancha，yiwanganzhaoSt Judefenqixitongquedingfenqi（jianfubiao1）。suizhuoyixuefazhan，ertongNHLxindebingliyaxingdezengjia，xibaoyichuanxue、fenzishengwuxuehemianyibiaoxingfangmiandejinbu，xindezhenduanfangfazaijianceweixiaokuosanbingzaohuoweixiaocanliubingzaodelinchuangyingyongyijiyingxiangxuefangmiandezhongyaojinzhan，zaiyuanyouSt Jude fenqixitongshangjinxingliaobuchonghegailiang，chanshengliaoxindefenqixitong：xiudingguojiertongNHLfenqixitong(IPNHLSS)，jinyibumingquehebuchongliaomeiyiqidedingyi，bingjiangzuixindeyixuejinzhanxinxijiaruliaofenqixitong（jianfubiao2）。2.gusuiqinfandezhenduan：xuyaoxinglianggebuweigusuichuancihezhishaoyigebuweigusuihuojianjinxingfenxidingyigusuiqinfan。（1）gusuichuancixibaoxingtaixue：gusuiyouzhixibaohuolinbaliuxibao≥5％。（2）gusuimianyibiaoxingfangfa(mianyizuzhihuaxuehuoliushixibaoshufenxi：tezhilinbaliuxibaobaifenbi)yangxing。（3）gusuixibaoyichuanxuehuoFISHfenxiyangxing。（4）gusuiPCRfangfajiancefenzishengwuxueyangxing。（5）gusuihuojiankeyijiandaozhongliuxibaojinrun。3.zhongshushenjingxitongqinfandezhenduan：naojiyezhuangtaifenjizhuyaoyijulinchuangbiaoxian、yingxiangxuegaibian、naojiyejiancha。（1） CNS1：tongshifuheyixiasantiao：①naojiyezhongwuzhongliuxibao；②wuzhongshushenjingxitongyichangdelinchuangbiaoxian；③wuzhongshushenjingxitongyichangdeyingxiangxue（CT/MRI）yiju。（2） CNS2：fuheyixiarenheyitiao：①yaochuanwusunshang—naojiyebuhunxue（hongxibao:baixibao≤100:1）shi，naojiyebaixibaojishu≤5/μl，bingjiandaomingquedezhongliuxibao；②yaochuanyousunshang—naojiyehunxue（hongxibao:baixibao＞100:1）shi，naojiyejiandaomingquedezhongliuxibao；③yaochuanyousunshangbingweixuexingnaojiye，bulunyouwuzhongliuxibao，ruchuzhenbaixibaoshu＞50×109/L zeguiwei CNS2；④zhongshulinjinbuweideqinfanweifasheng CNS qinfandeweixianyinsu，weiliaojiaqiangyufangguiwei CNS2：toumianbupifu、ruanzuzhihuoguzuoqinfan，rulugu、bizuo、yankuangdeng（weitupoyingnaomo）；jizhugupohuaihuozhuipangqinfanbubanshenjingxitongzhengzhuangde，wu CNS zhanwei、naojiyejianchazhengchang。（3）CNS3：fuheyixiarenheyitiaowei CNS qinfan：①naojiyebaixibaojishu＞5/μl，bingyizhongliuxibaoweizhu，tongshihongxibao:baixibao≤100:1；huozhenaojiyebaixibaojishu＞5/μl，qizhongzhongliuxibaosuozhanbiligaoyuwaizhouxueyouzhixibaobaifenbi；②lushenjingmabi，jishinaojiyezhongwuzhongliuxibao、lunao MRI/CT weifaxianzhanweixingbingbian；③CT/MRI kejiannao、jisuihuonaomo、jimobingbian。④jizhugupohuaihuozhuipangqinfanyinqipainiaoyichang、zhitihuodongzhangaidengshenjingxitongzhengzhuang。4.zuowanqinfandezhenduan：huanerbiaoxianweizuowandancehuoshuangcezhongda，zhidibianyinghuochengjiejiezhuangquefadanxinggan，touguangshiyanyinxing，B chaojianchakefaxianzuowanchengfeijunzhixingjinrunzao，chuzhenhuanerkebuyuhuojian。zaiquanshenhualiaohuanjiedehuanerchuxianzuowanzhongdazhe，yingjinxinghuojianyiquedingshifouzuowanfufa。（si）jianbiezhenduan1.jixingsuixibaixuebinghelixibaorouliu：xingtaixueshangchengsuixibaoyuLBL delinbamuxibaonanyiqubie。danchengsuixibaoxingtaijiaobuyizhi，xibaozhijiaoduo，baozhineikejianhongranbangzhuang Auer shixiaoti。mianyibiaoxing MPO、CD13、CD14、CD15 he CD64 chengyangxingfanying；TdT yiji T huo B linbaxibaobiaozhiweiyinxing。2.Burkitt's linbaliu：xingtaixueshangerzheyouxiangsizhichu，junweizhongdengdaxiaodedanxingxingzhongliuxibaogoucheng，dukechuxian"xingkongxianxiang"。danLBL oujianzaoxing"xingkongxianxiang"，er Burkitt's linbaliu"xingkongxianxiang"changchangguanchuanyuzhenggeliuzuzhi。liuxibaobiaoda sIgM、CD10、EBER1/2 yuanweizajiaoyangxing。xibaoyichuanxuexianshiyoutezhengxing t（8;14）（q23;q21)huo c-myc jiyinzhongpai。3.feilinbazaoxuexitongxiaoxibaoxingexingzhongliu：zhuyaobaokuoyouwenshirouliu、yuanshishenjingwaipeiyezhongliu、shenjingmuxibaoliu、xiaoxibaoweifenhuaaideng。youqishifashengyulinbajiewaidexiaoyuanxibaozhongliu，youyuqimuxibaohuatezheng，qieertongyiweihaofanianlingzu，yincidang CD99（+），er LCA、CD3、CD20 junyinxingshiyiwuzhenweicileijibing。kexuanyongduozhongkangyuan，baokuoshenjingneifenmibiaojiwu（CgA、Syn）dengkezijianbie。4.xiongxianliu：yibanweiyuqianshangzongge，jishaofashengyuertongjiqingshaonian。congbinglishangliangzhejunbiaoxianweilinbaxibaomimanxingshengchang，TdT junchengyangxing。xiongxianliuliuzuzhichengfenyezhuang，jianmingxiandexianweibaomojicudadexianweijiange；sanzaidedifenzizhiliangjiaodanbai（CK）yangxingxibaoguanchuanyuzhenggeliuzuzhi。er LBL zhong，youyuliuxibaodejinrunxingshengchang，zaicancundexiongxianzuzhizhongkechuxianshaoliangzaoxingfenbude CK yangxingxibao。5.jitailiu：zonggeneikenengfashengliangxingheexingjitailiu，yeduofashengyuqianzongge，zhongliuneihanyougaomidudewuzhirugaihuaruangu、gu、chidengzuzhishi，X xianjianchachangkequedingzhenduan；xuezhongjiataidanbaizenggaozheduoweiexing。6.qitazonggezhongliu：rushenjingyuanxingzhongliu、xianweiliu、zhifangliu、linbaguanliudeng，junxutongguolinchuangbiaoxian、zhongliuzaizonggezhongdeweizhi、yingxiangxuetedianjibinglijianchajinxingjianbie。（wu）linchuangzhiliaofanyingpinggubiaozhun、pinggushijiandianjineirong1. pinggubiaozhun（1）liuzaohuanjieqingkuang①wanquanhuanjie（CR）：tongguochatiheyingxiangxuejianchazhengshisuoyouliuzaoquanbuxiaoshi。CT xianshiyuanzhongdadelinbajiehezhongkuaiyisuoxiaozhizhengchangfanwei（zuidajingxian＜ 1.5 cm），geqiguanyingxiangxuekejiandaodesuoyouliuzaojunyixiaoshi。PET saomiaoyiwuyangxingfaxian。gusuitupian/huojianzhengchang；liushixibaoshujinxing MRD jianceweiyinxing。②weiquedingdewanquanhuanjie（Unconfirmed complete response）：suiranbingzaozuidajing＞1.5cm，danzongtishangbingzaosuoxiao＞75%（xianghuchuizhiliangtiaozuidahengjing）。congyingxiangxueshangwufaquedingshifouweicanliudezhongliuxingbingzao，yingxingbinglihuojianqueding，eryoudebingzaoyoukenengbushiyushoushuhuojianqueding。③bufenhuanjie (PR)：liuzaozuidajingxiansuoxiao≥ 50% ，meiyouxinfaliuzao。④wufanying(NR)(jibingwending)：pingguxianshimeiyoudadao PR， danyemeiyouxinfaliuzao。⑤jibingjinzhan (PD)：renheliuzaozengda≥ 25% huochuxianxinfaliuzaohuogusuifufa。（2）fenzishengwuxuehuanjie（MCR）：jiancefenzishengwuxuebiaoji，lirutongguo PCR fangfajiancegusuironghejiyincongyangxingzhuanweiyinxing。（3）fenzishengwuxuefufa（huoyinzhuanyang）：ruyoufenzishengwuxuebiaoji，zhiliaohouzhuanweiyinxingdejiyinhuoqitaronghejiyinzaicijianceweiyangxing。2.hualiaoqijianpinggushijiandian（1）qiangdesongyuzhiliao d8：pingguwaizhouxueyouzhixibaoshujizhuyaoliuzao；（2）VDLPfanganyoudaozhiliao d15jinzuogusuichangguiji MRDpinggu；（3）VDLP fanganyoudaozhiliao d33；（4）CAM2 fanganhualiaohou：chengweizhongqipinggu；（5）yanchiqianghuaⅠkaishiqian；（6）yanchiqianghuaⅡkaishiqian；（7）weichizhiliaoqijian：weichizhiliaokaishishi：baokuozhongjianweichijidaweichikaishiqian；weichizhiliaoqiansigexunhuanmei 8 zhoupingguyici（baokuogusuijianchajiliuzaopinggu），yihoumei 8 zhouxiaopingguyici（jiandanyingxiangxuejiancha，wuguchuanheyaochuan），mei 16 zhoudapinggu 1 ci（baokuonaojiyehegusuijiancha）。3.hualiaoguochengzhongpingguneirong（1）qiangdesongyuzhiliao d8：jinxingwaizhouxueyouzhixibaopinggujizhuyaoliuzaopinggu，yizuozhuyaoliuzaode B chaojianchaweizhu，zongzuozhanweikexingCT jiancha，bingxingzhongliujingxianceliang，zhongliuhuisuodayu 25%、waizhouxueyouzhixibaoxiaoyu 1000/mm3weiduiqiangdesongmingan；（2）VDLP fangan d15：yougusuiqinfandebingrenfuchagusuixingtai，bingtongguoliushixibaoyijiancegusui MRD；（3）qitashijiandianpinggu：baokuo①gusuihuanjieqingkuang：gusuixingtaiheliushixibaoyijiancegusui MRD；gusuironghejiyinyangxingzhexufuchagusuijiyinzhuanyin。②liuzaoqingkuang：liuzaobuweixiangguanyingxiangxuejiancha。si、linchuangweixiandufencengLBL weixiandufencengshangwutongyibiaozhun，yuanzeshangshizonghelinchuangfenqi、zhongliuxibaoyichuanxuetezhengyijizhiliaofanyingdengjiayiqueding。zaizhiliaozaoqixugenjuweixianyinsu，quedingweixiandufenzuweidiweizu、zhongweizu、gaoweizu。（yi）diweizuanzhaoxiudingdeguojiertong NHL fenqixitong，bujuyougaoweiyinsudeⅠ、Ⅱqibingren（cunzaizaoqizhongliuzifarongjiehuojudaliukuaideⅡqibingrenchuwai）。（er）zhongweizubujuyougaoweiyinsudeⅢ、Ⅳqibingren。（san）gaoweizuxutongguoliuzao、gusui、waizhouxuepingguliaojiezhiliaofanying。1.qiangdesongyuzhiliao d8，waizhouxueyouzhixibaodayu 1000/mm3。2.youdaozhiliao d15 gusuiyouzhixibao＞25%。3.youdaozhiliao d33 zhongliucancun＞25%huogusuiyouzhixibao＞5%；gusui MRD≥10-2；naojiyezhongchixucunzaiyouzhixibao（zhisanciqiaozhuhounaojiyezhongrengyouzhongliuxibao）。qizhongrenyixiang。4.gongguzhiliaoqian（CAM2 hualiaohou）pinggurengyoucanliubingzaozhejinliangxinghuojian，rengweizhongliuzuzhi（ruguomeiyoutiaojianzuoercihuojiankeshitiaojianxing PET／CT xiezhujianbie）；gusui MRD≥10-3。qizhongrenyixiang。5.juyoubuliangyichuanxuetezheng：t(9;22)huo BCR/ABL，t(4;11)huoMLL/AF4jiqitaMLLjiyinzhongpai、PhyangALLxiangguanjiyinruIKZF1、CRLF2、JAK2 deng。wu、zhiliao（yi）xitonghualiao1.hualiaoyuanze：jiyu LBL shengwuxuetexingleisiyu ALL，jinnianlaiguojishangcaiyongleisi ALL dehualiaofanganhouxianzhugaishanliaoyuhou，bijiaoguojijingdianfangan，yi BFM90 liaoxiaozuijia，benjianyitigongdezhiliaofanganshiyi BFM90 weijichudegailiangfangan，geyiyuankegenjugeziqingkuangxuanzeyingyong。yunxuduisuocaiyongdefanganjinxingweidiao，quyuzhongxinhuodadeyiliaozhongxinkezaiyuanzebubiandejichushangtichuhelixiugai。2.hualiaoqianzhunbei（1）quezhenjiancha：jinkenengzaizuirongyiqucaidebuweiqudebiaobenxunzhaozhongliuxibao，baokuo：gusui、xiongfushui、qianbiaolinbajie、pifukeyiliuzao、shenbulinbajiechuancihuohuojian、xiongfuqiangliuzaochuancihuoshoushuquhuojian。ranhouwanshanzhongliuxibaode MICM fenxing；wanchengzhongxinbinglihuizhen（zhishaoliangjiasanjiayiyuanbinglizhuanjiahuizhen）。（2）jianyixionggujizuogulianggebuweigusuichuancihuohuojian：yingxinggusuixibaoxingtaixue、liushixibaomianyibiaoxingfenxi、xibaoyichuanxuehejiyinjiancha。（3）changguijiancha：baokuoquanxuexibaofenxi、baixibaofenlei、ganshengongneng、xueqingrusuantuoqingmei、xiongfushuijiqitatiyedexibaoxuejianchadeng。（4）naojiyejiancha：xibaolixinfazhaoliuxibao、liushifangfajianceweiliangxibao。（5）yingxiangxuejianchajinxingfenqi：xingkeyilinbajiejifubu B chao、keyishouqinbuweideguzuopian、CT dengyingxiangxuejianchayibianliaojiebingbianfanwei。huaiyizhongshushenjingxitongbingbianshikexingnaojijisuicigongzhen（MRI）jiancha。youtiaojiandexing PET/CT jiancha。（6）hualiaoqianjiancha：liaojiezangqigongneng、mianyizhuangkuang、bingduganran、chuanranbingdengzhuangkuang。3.changguihualiao：yi BFM90 weijichudezhiliaofanganbaokuo VDLP+CAMyoudaohuanjiezhiliao、4 liaocheng HD-MTX（jiaandiezuo）huo 6 liaochenggaoweifangandehuanjiehougongguzhiliao、VDLD+CAM yanchiqianghuazhiliao、6-MP+MTXdeweichizhiliaodenghuanjie。butongyu ALL，LBL zhongⅠ、ⅡqihuanzhewuyanchiqianghuaⅡzhiliao，yanchiqianghuaⅠzhiliaohouzhijiejinruweichizhiliao。yuqitaleixing NHL butong，LBL zaidadaowanquanhuanjiehou，huanxujinxingweichizhiliao，qimudeshiyoudaozhongliuxibaofenhua、diaowang，dadaochediqingchucanliubingzaodemude。zongliaochengyuewei 24 geyue。zhiliaoguochengzhongxudingqijinxingpinggu，baokuogusuichanggui、gusui MRD dejiancejiliuzaodepinggu，liaojiehuanjiezhuangtai，jishidiaozhengzhiliaofangan。4.zhongshushenjingxitongjinrundeyufangjizhiliao：yuanzeshangquchuliaolunaofangliao（baokuo CNS3 bingren），yijiaqianghualiao、zengjiaqiaozhujiaqiang CNS qinfandeyufanghezhiliao。（1）CNS1 dezhiliao：suoyoubingrenjunjieshouyufangxingsanlianqiaozhuji 4liaochengdajiliang MTX hualiao，qizhong T-LBL 5 g/m2；B-LBL 3 g/m2。zhenggehualiaoguochengzhong，B-LBL zhishao IT 20 ci，T-LBL 22 ci。（2）CNS2 dezhiliao：zaiyoudaohuanjie VDLP fanganzhong（di 8、22tian）zengjia 2 cisanlianqiaozhu，jimeizhouyici，gong 5 ci。quanchenggong 22～24 ci。（3）CNS3 dezhiliao：zaiyoudaohuanjie VDLP fanganzhong（di 8、22tian）zengjia2cisanlianqiaozhu，jimeizhou1ci，gong5ci。yanchiqianghuaⅠ VDLD（di 1、15 tian）zengjia 2 ciqiaozhu。quanchenggong 26～30 ci。（4）weichizhiliaoqijiande CNS zhiliao：CNS2（baokuozhongshulinjinbuweiqinfanzhe）、CNS3 bingrenweichizhiliaoqijianzengjialiangciqiaozhu。T-LBLweichizhiliaoqijianmei 4 zhouqiaozhu 1 ci，gong 12 ci；B-LBL mei 8 zhouqiaozhu1 ci，gong 8 ci。zhu：annianlingsanlianqiaozhujiliang（jianfubiao 3）。5.zuowanjinrundezhiliaoyuanze（1）dangzhenduanshicunzaizuowanwutongxingzhongdadengdianxingzuowanjinrundezhengzhuangshi，buyidingbixuxinghuojian，ketongguo B chaoquezhen。ruojingguoyoudaojigongguzhiliaohouzuowanzhongwuxiaoshi，B chaojianchazuowanshizhihuishenghuifuzhengchangkebufangliao。（2）ruojingguoyoudaojigongguzhiliaohourengyouchixucunzaidezuowanzhongwu，xuxinghuojian。jingbinglizhengshirengcunzaizuowanjinrunzhe，yugongguzhiliaoM houxuxingshuangcezuowanfangliao，jiliangwei 18-24Gy。（er）hualiaofangan1.chushiyoudaohualiaofangan：VDLP fangan+liangliaocheng CAM fangan。（1）VDLP fanganyoudaozhiliao：changchunxinjian（VCR）1.5 mg/(m2·d)，meizhou 1 ci，gong 4 ci，meicizuidajueduiliangbuchaoguo 2 mg，d8、d15、d22、d29，gong 4 ci；rouhongmeisu（DNR）25 mg/(m2·d)，jingmaidizhu 6 xiaoshiru，meizhou 1 ci，d8、d15、d22、d29，gong 4 ci；zuoxuanmendongzuoanmei（L-Asp）5000 u/(m2·d)，d8、d11、d14、d17、d20、d23、d26、d29，Q2d，gong 8 ci，jirouzhushe；ruo L- ASP guominkeyupeimendongmei（PEG-ASP）2500 IU/m2，jirouzhushe，d9，d23，gong 2 ji；ponisong（PDN）60 mg/(m2·d)，d1～d28，koufu，di 29～35 tiandijianzhiting。PDN duiyuzhongliufuhedadehuanzheqishijiliang[(0.2～ 0.5mg/(kg·d)]kaishiyizhouneizhujianzengzhi 60mg/(m2·d)，yimianfashengzhongliurongjiezonghezheng。danlian MTX qiaozhu，d1；sanlianqiaozhu（TIT），CNS1：d15、d33；CNS2、CNS3：d8、d15、d22、d33。（2）CAM fangan：ruohuanerwufare、wuyanzhongganran；ANC≥0.5×109/L，PLT≥50×109/L shi，keyu d36 kaishidiyilun CAM fangan。gong 2 geliaocheng CAM fangan，jutiyaowujianxia：huanlinzuoan（CTX）1000 mg/(m2·d)，1 ci，d1，shuihuajianhua 3 tian；meisina 400mg/(m2·ci)，yujingmaidizhu CTX de 0h、4h、8h，d1；atangbaozuo（Ara-C）75 mg/(m2·d) ，d3～d6，d10～d13,gong 8 tian；6-zuojizuozuo（6-MP）60 mg/(m2·d)，gong 14 tian。sanlianqiaozhu，d10。xiuliao 1-2 zhou；ANC≥0.5×109/L，PLT≥50×109/L；wufarejiyanzhongganran；kaishidi 2 lun CAM。2.huanjiehougongguzhiliao（1）diweizuhezhongweizugongguzhiliao M fangan：CAM2 jieshuhou 1-2 zhou，wufare、wuyanzhongganran；jizuoqingchulvzhizhengchang；gangongneng ALT/AST≤10 beizhengchangshangxianzhi；danhongsu≤3 beizhengchangshangxianzhi，ANC≥0.5×109/L，PLT≥50×109/L shikeyikaishigongguzhiliaofangan M。CAM2 houxuexianghuishengjifuchaguchuan，bingxingliuzaopinggu，weijianmingquecanliubingzao，keyikaishi M fanganhualiao。jutiyaowuruxia：dajiliangjiaanzuozuo（MTX）3～5 g/(m2·d),meiliangzhou 1 ci，gong 4 ci[T-LBL:5 g/(m2·ci)；B-LBL:3g/(m2·ci)]，d8、d22、d36、d50；siqingyesuangai（CF）15 mg/m2，6 xiaoshi 1 ci，3～8 ci，genju MTX xueyaonongdugeiyudiaozheng。6-MP 25 mg/(m2· d)，buchaoguo 56 tian，genju WBC diaozhengjiliang。sanlianqiaozhu：d8、d22、d36、d50。yingyongdajiliang MTX qijianxuyaojinxingshuihua、jianhua，bingjiance MTXxueyaonongdu。45 xiaoshicha MTX nongduxiaoyu 0.25μmol/L weizhengchang。ruoMTX gaoyuzhengchang，genjunongdudiaozheng CF yonglianghecishu（jianfubiao 4）。（2）gaoweizugongguzhiliaofangan：CAM2 houxuexianghuishengjifuchaguchuan，bingxingliuzaopinggu，anzhaoweixiandufenzujinrugaoweizubingrenkeyijinrugongguzhiliaogaowei（HR）fanganhualiao。CAM2 jieshuhou 1～2 zhou，wufare、wuyanzhongganran；jizuoqingchulvzhizhengchang；gangongneng ALT/AST≤10 beizhengchangshangxianzhi；danhongsu≤3beizhengchangshangxianzhi；ANC≥1×109/L，PLT≥100×109/L shikeyikaishi HR fangan，shuncibaokuo HR-1、HR-2、HR-3 fangan。① HR-1 fangan：DXM 20mg/(m2·d)，koufuhuojingmaituizhu，d1～d5；VCR 1.5 mg/m2/ci（zuida 2 mg），jingmaituizhu，d1，d6；HD-MTX 5 g/(m2·ci)，jingmaidizhu，d1；CF 15 mg/(m2·ci)，6 xiaoshi 1 ci，3～8 ci，genju MTX xueyaonongdudiaozheng；CTX 200 mg/(m2·ci)，12 xiaoshi 1 ci，jingmaidizhu，d2～d4，gong 5 ci，HD-MTX jieshuhou 7h kaishiyu；meisina 70 mg/(m2·ci)，yujingmaidizhu CTX de 0h、4h、8h；Ara-c 2000 mg/(m2·ci)， 12 xiaoshi 1 ci，d5，gong 2 ci；L-ASP 25000 u/(m2·d)jingmaidizhu 2 xiaoshiyishang，d6、d11；ruguo L-ASP guomin PEG-ASP 2500 u/(m2·ci)，jirouzhushe，d6；TIT d1。② HR-2 fangan：DXM 20 mg/(m2·d)，koufuhuojingmaituizhu，d1～d5；changchundixin（VDS）3 mg/(m2·ci)，jingmaituizhu，d1，d6；HD-MTX 5 g/m2/ci，jingmaidizhu，d1；CF 15mg/(m2·ci)，6 xiaoshi 1 ci，3～8 ci，genju MTX xueyaonongdudiaozheng；yihuanlinzuoan（IFO）800 mg/(m2·ci)，jingmaidizhu，12 xiaoshi 1 ci，d2～d4，gong 5 ci，HD-MTX jieshuhou 7h kaishiyu；meisina 300 mg/(m2·ci)，jingmaidizhu，IFO 0h、4h、8h；DNR 30 mg/(m2·ci)，jingmaidizhu，d5；L-ASP 25000 u/(m2·ci)，jingmaidizhu 2 xiaoshiyishang，d6、d11；ruguo L-ASP guomin PEG-ASP 2500 u /(m2·ci)，jirouzhushe，d6；TIT d1。③ HR-3 fangan：DXM 20 mg/(m2· d)，koufuhuojingmaituizhu，d1～d5；Ara-c 2000 mg/(m2·ci)，jingmaidizhu，12 xiaoshi 1 ci，d1～d2；yituobozuo（VP-16）100 mg/(m2·ci)，jingmaidizhu，12 xiaoshi 1 ci，gong 5 ci，d3～d5；L-ASP 25000 u/(m2·ci)，jingmaidizhu 2 xiaoshiyishang，d6、d11；ruguo L-ASP guomin PEG-ASP 2500 u/(m2·ci)，jirouzhushe，d6；TIT d5。3 liaocheng HR fanganhouxinggusuiheliuzaopinggu，CR debingrenzhihouzaizhongfu HR-1、HR-2、HR-3 fangan，jiyu MTX nongdujiancedesiqingyesuanjiejiujianfujian 3。ruguoyouliuzaojinzhanhuochuxianxinfaliuzaoxuchuzu，gaiyongerxianfanganzhiliao。3.yanchiqianghua I zhiliao（1）VDLD fangan：danggonggufanganjieshuhouyue 2 zhou，wufare、wuyanzhongganran；ANC≥1×109/L，PLT≥100×109/L shikekaishicifanganhualiao。benliaochenghualiaoqianfuchagusui，bingxingliuzaopinggu。jutiyaowuruxia：VCR 1.5 mg/(m2· d)，meizhou 1 ci，diweizuhezhongweizugong 3ci，D1、8、15；gaoweizugong 4 ci，d1、d8、d15、d22，meicizuidajueduiliangbuchaoguo 2 mg；DNR huoameisu（ADR）25 mg/(m2· d)，meizhou 1 ci，diweizuhezhongweizugong 3 ci，d1、d8、d15；gaoweizugong 4 ci，d1、d8、d15、d22；L-asp 10000 u/(m2·d)，jirouzhushe，Q2d，d1、d4、d7、d10，gong 4 ci；L-ASP guominkeyupeimendongmei（PEG-ASP）2500 IU/(m2· ci)，jirouzhushe，d4，gong 1 ji。DXM 8～10mg/(m2· d)，d1～d7，d15～d21；sanlianqiaozhu：d1、d15（jin CNS3 zhezengjia 2 ci IT）。(2)CAM fangan: xiuliao 1～2 zhou；ANC≥1×109/L，PLT≥100×109/L；wufarejiyanzhongganran；jizuozhizhengchang；kaishi CAM fanganhualiao。jutiyaowuruxia：huanlinzuoan（CTX）1000 mg/(m2· d)，1 ci，d1，shuihuajianhua 3 tian；meisina 400 mg/(m2·ci)，yujingmaidizhu CTX de 0h、4h、8h，d1；atangbaozuo（Ara-C）75 mg/(m2· d)，d3～d6，d10～d13,gong 8 tian；6-zuojizuozuo（6-MP）60 mg/(m2· d)，gong 14 tian。sanlianqiaozhu，d3。xiuliaoyue 2 zhou，wufarejiyanzhongganran；ANC≥0.2×109/L，PLT≥50×109/L；kekaishiweichizhiliao。4.zhongjianweichizhiliao。zhongweizubingrenwanchengyanchiqianghuaＩhoujinru 8zhouzhongjianweichizhiliao（jiyong 8 zhou 6-MP+MTX/VD fangan，jutifanganwei：6-MP 50 mg/(m2·d)，chixushuiqiankongfukoufugong 8zhou；MTX 20 mg/m2，meizhou 1 ci，gong 8 ci，koufuhuojirouzhushe，genju WBC diaozhengfanganzhong6-MP dejiliang。VCR 1.5 mg/(m2· d)，1 ci，d1，meicizuidajueduiliangbuchaoguo 2 mg；DXM 6mg/(m2· d)，d1～d5。sanlianqiaozhu，d1。5.yanchiqianghuaⅡzhiliao（1）VDLD fangan：zhongweizubingrenwanchengzhongjianweichizhiliaohoufuchagusui，bingxingliuzaopinggu，chuyuwanquanhuanjiezhuangtai，jinruyanchiqianghuaⅡzhiliao。danghuanerwufare、wuyanzhongganran；ANC≥1×109/L，PLT≥100×109/L shikekaishicifanganhualiao。jutiyaowuruxia：VCR 1.5 mg/(m2· d)，meizhou 1 ci，gong 3 ci，d1、d8、d15，meicizuidajueduiliangbuchaoguo 2 mg；DNR huoameisu（ADR）25 mg/(m2· d)，meizhou 1 ci，gong 3ci，d1、d8、d15；L-asp 10000 u/(m2· d)，jirouzhushe，Q2d，d1、d4、d7、d10，gong 4 ci；L-ASP guominkeyupeimendongmei（PEG-ASP）2500 IU/m2，jirouzhushe，d4，gong 1 ji。DXM 8-10mg/(m2· d)，d1～d7，d15～d21；sanlianqiaozhu：d1。(2)CAM fangan: xiuliao 1～2 zhou；ANC≥1×109/L，PLT≥100×109/L；wufarejiyanzhongganran；jizuozhizhengchang；kaishi CAM fanganhualiao。jutiyaowuruxia：huanlinzuoan（CTX）1000 mg/(m2· d)，1 ci，d1，shuihuajianhua 3 tian；meisina 400dmg/(m2· ci)，yujingmaidizhu CTX de 0h、4h、8h，d1；atangbaozuo（Ara-C）75 mg/(m2· d) ，d3～d6，d10～d13,gong 8 tian；6-zuojizuozuo（6-MP）60 mg/(m2· d) ，gong 14 tian。sanlianqiaozhu，d3。6.weichizhiliaofangan：diweizuhegaoweizubingrenwanchengyanchiqianghuaＩhoujinruweichizhiliaojieduan。ji 6-MP+MTX fanganqijianmei 4 zhoucharu VDfanganyici。kaishiweichizhiliaoshixingliuzaopinggu，weichizhiliaoqiansigexunhuanmei 8zhoupingguyici（baokuogusuijiancha），yihoumei 8 zhouxiaopingguyici（jiandanyingxiangxuejiancha，wuguchuan、yaochuan），mei 16 zhoudapinggu 1 ci（baokuonaojiyehegusuijiancha）。（1）6-MP+MTX fangan：6-MP 50 mg/(m2· d)，chixushuiqiankongfukoufu；MTX 20 mg/m2，meizhou 1 ci，koufuhuojirouzhushegenju WBC diaozhengfanganzhongdeyaowujiliang。（2）VD fangan：VCR 1.5 mg/(m2·d)，1 ci，meicizuidajueduiliangbuchaoguo 2 mg；DXM 6～8 mg/(m2· d)，d1～d5。- 24 -zongzhiliaoliaocheng： yue 2.5 nian。（san）LBL fufahoudezhiliaoceluedayue 10%～20%jinzhanqi LBL shunanzhihuofufabingli。huanjiehouyidanfufa，wangwangbingqingjiqixiongxian，xunsuquanshenduozangqizhuanyi，zaicihuanjiekunnan，yuhoujicha，shengcunlvjinwei 10%～30%。bujiuzhiliaozhuyaobaokuozaiciyoudaohezaoxueganxibaozhichideqianghuazhiliao。bujiudemubiaoshijinkuaidadaowendingdeercihuanjie（second complete remission， CR2），jinzaoxingzaoxueganxibaoyizhi（haematopoietic stem cell transplant，HSCT）。wanjiuhualiaochangyongdeerxianzhiliaodexibaoduleiyaowuyouyihuanlinzuoan、qujiayangrouhongmeisu、kabodeng。xianyoushujubiaomingfufa LBL weijing HSCT jihuwuzhiyudejihui，erxiangbizitiHSCT（autologous HSCT，auto-HSCT），yijiyin HSCT（allogenic-HSCT，allo-HSCT）suiyoujiaogaodezhiliaoxiangguansiwang，danjuyougenggaodewubingshengcunlv，auto-HSCT fufalvmingxiangaoyu allo-HSCT。1.T-LBL wanjiuzhiliao（1）nailabin（Nelarabine，Arranon）：shituoyangniaozuoleisiwu 9-b-D-atangzuozuotangniaozuozuo（ara-G）deqiantiyaowu，dui Tlinbamuxibaode DNA hechengjuyouxuanzexingyizhizuoyongerzhixibaosiwang。shiyizhongyouxiaode T xibaoteyixingxibaoduyaowu，yongyuzhiliaonanzhi、fufade T-LBL/ALL，takedanyaozhiliaohuoyuqitaxibaoduyaowulianyong。ertongyingyongjiliang 650 mg/(m2· d) ×5 d，21d yiliaocheng，Ⅰ/Ⅱqiertongjichengrenyanjiu，danyaofanyinglv 14%～55%。changjiandefuzuoyongweijiliangyilaixingshenjingduxing，biaoxian 2 jihuo 3 jiganjue、yundongshenjingbingbianhejirouguzuotengtong，youdebingrenbiaoxiantoutong、shishui、ganjuechidun、zuozuofazuo、gongjishidiaodeng，duoweikenixingde。qitafuzuoyongweixueyeduxing、exinoutudengxiaohuadaofanying。nailabinzhiliaofufa/nanzhi T-ALL/LBL zuichangyongdelianhehualiaoshihuanlinzuoanjiayituobozuo，Leah dengbaodao 5/7 CR，qizhong 4 lideyijinxing HSCT，danjin 1 licunhuo，qitabingrensiyujibingjinzhanhezhiliaoxiangguanhebingzheng。chuliaolianhehualiao，K Burley baodao 1 liyizhihoufufadeT-ALL caiyongnailabinjiagongzhexibaohuishudadaochixu CR。Annalisa dengtichukeyigenjubingrenjiyinbiaodapu，banailabinxuanzexingdilianhe PI3K、Bcl2、MEK yizhiji，yizengjiaqiliaoxiao。（2）daleimudankang（Daratumumab）：CD38 renyuanhuadankang，CD38kangyuanzaihualiaoqianhouhuozaifufahouT-ALL/LBLxibaoshangbiaodawending，kenengchengweilianghaodezhiliaobadian。bingkezuowei CAR-T xibaozhiliaodebadian，muqianjunzaitansuozhong。（3）qita：ru PI3K yizhiji、mTOR yizhijihuo PI3K-mTORshuangzhongyizhijilianhetangpizhijisuyongyugaowei PTEN queshidebingren；lusuolitini（ruxolitinib）：JAK/STAT tongluyizhiji，nenggoukefutangpizhijisunaiyaodengjunzaiyanjiuzhong。2.B-LBL wanjiuzhiliao（1）laoansuanjimeiyizhiji（TKI）：keyongyuzhiliaochuzhihefufade Ph+ALL / LBL，tongguobaxiangzuoyongyu BCR/ABL ronghejiyincongerfahuiliaoxiao。yimatinidanyaoyouxiaolvda 70%，lianhehualiao CR lvkeda90%。dierdaidashatiniheniluotinikeyongyuduiyimatininaiyaodebingren，juyoutouguoxuenaopingzhangdetexing，liaoxiaoyouyuyimatini。（2）CD19 teyixingqianhekangyuanshouti T xibao（CAR T xibao）：zhiliaofufa/nanzhi B-ALL/LBL CR lvdadao 70%～92%，liaoxiaoxianzhu，huanjiehoukeqiaojieyizhi，CAR-T xibaozhiliaodeduxingweixibaoyinzishifangzonghezhengheshenjingduxing。（3）qitarushuangteyixingkangti（Blinatumomab）、pengtizuomi（Bortezomib）deng，zhiliaofufa/nanzhiALL/LBLjunyouyidingliaoxiao。（si）zaoxueganxibaoyizhi1.duihualiaoguochengzhongduogepinggudianxianshiduihualiaobumingan，zhongqipingguyou mingquecan liubing zao；huo cunzaiyu houbu liangjiyin ：juyout(9;22)/BCR-ABL1、MLL zhongpaideng，keangaoweizufanganhualiao，wanchengsanliaochenggaoweifanganbaokuo HR-1、HR-2、HR-3 houxingyijiyinzaoxueganxibaoyizhi。2.duiyuyuanfaliuzaofufahuogusuifufahuozhiliaozhongjinzhandebingrentongguowanjiuzhiliaonenggoudadaowanquanhuanjiehuobufenhuanjiehuodeyizhijihuizhe，xujinkuaixingyijiyinzaoxueganxibaoyizhi。liu、hebingzhengdechuli（yi）duicunzaishangqiangjingmaiyapozonghezheng、qidaogengzudebingrendechuliyuanzedayue 10%T-LBL kenengchuxianyanzhongdeqidaogengzu（banhuobubanshangqiangjingmaiyapozonghezheng），weizhenzhengzhongliujizheng。1.duicileibingrenshangweijingbingliquezhenzhe，jinjiyingyongquanshenmazuishoushuhuojian。2.kexianyuxiaohualiao（ruponisong 60 mg/m2koufuhuo VP fangan）huanjiehuxikunnan，yuyongyaohou 24～48 xiaoshineizhengzhuangkongzhihoujinzaoxingbinglijiancha，bingyingxuanzeqinxixingzuixiaodecaozuoquezhen，keyikaolvqucaishunxuwei：gusui、xiongfushui、qianbiaolinbajie、pifuhuoqitaqianbiaokeyiliuzao、shenbulinbajiehuozhongwuchuancihuojian、liuzaoshoushuquhuojian。hualiaoqianxuqianshuweiquezhenhualiaoxieyishu，gaozhijiachanghualiaokenengyingxiangbinglijieguoerwufaquezhen。3.duibanyoushangqiangjingmaiyapozonghezhengdebingrenyingbimianshangzhishuye。（er）zhongliurongjiezonghezhengdechulicunzaigaozhongliufuhede、hualiaoqianyiyougaoniaosuanxuezheng、shengongnengsunhai、shaoniaoshuizhongdebingrenweifashengzhongliurongjiezonghezhengdegaoweirenqun，xucaiqujijideyufanghezhiliaocuoshi。1.yanmijiancegexiangshengmingtizheng、churuliang、tizhong、xuedianjiezhi、ganshengongneng。2.yingyongbiezuochunjianshaoniaosuanshengcheng：10mg/(kg· d)[300mg/(m2· d)]，fen2～3cikoufu。biyaoshiyingyongniaosuanyanghuamei0.1～0.15 mg/(kg·ci)kexunsujiangdiniaosuanshuiping。3.jijishuihualiniao：3000 ml/(m2· d)[125 ml/(m2· h)]，yong1/4～1/3zhangyeti，yibanbuyonghanjiaye。geiyusuniao0.5～1mg/(kg·ci)，Q12hliniao，baozhengchurupingheng，weichiniaoliangdayuezai125 ml/(m2· h)。buchongzugouyeti，kebubijianhua，yifangjianhuatiaojianxialinsuanyanhehuangzuozuozaishenxiaoguanchenjijinyibujiazhongshensunshang。（san）duiyoushenjingxitongqinfanhuoyapodebingrenchuliyuanzejinkuaiwanshanjiancha，jinzaohualiao，yifangnao、jisuihuozhouweishenjingyapohuoqinfanguojiu，zaochengshenjingxitonggongnenghuifuyanchishenzhibukenidesunshang。bingan CNS2、CNS3 geiyuqiaozhu。qi、zhiliaozhongqitazhuyishixiang（yi）hualiaohoujiancexuechanggui，ANC ＜0.5×109/L，PLT＜100×109/L，kepixiazhushelixibaocijiyinzi（G-CSF）5μg/(kg·d)zhiANC＞1×109/Ltingyong。（er）hualiaoyaowudufufanyingdepandingbiaozhunan NCI buliangfanyingdefenjibiaozhun（CTCAE version 4.0，2009)jiance，hualiaoqianhoujunxuzhuyijiancexindiantu、chaoshengxindongtu、ganshengong、niaochanggui、xuedianfenmei、ningxuegongnengdengjiayiyufang。（san）yufangkashifeinangchongfeiyanchangguikoufufufanghuanganyizuo[25 mg/(kg· d)，meitian 2 ci]，meizhoufu 3 tianting 4tian，hualiaokaishizhidaohualiaojieshuhou 3geyue。HD-MTXyongqian 24 xiaoshidaoyong MTX houzhishao 72 xiaoshitingyongfufanghuanganyizuo。ba、tingyaohousuizhenshijianjipingguneirong（yi）shoucipinggu(tingyao 3 geyue)fuchagusuichanggui、jiyinhe MRD；liuzaopinggubaokuo B chao、CT deng，zuihaozuo PET/CT；fuchamianyigongnengjixindiantu、xinzangcaichao；fuchaganshengong、LDH。（er）tingyaodi 1、2 nianmei 3 geyue 1 cijiandanpinggu，baokuoguchuanheliuzaodeyingxiangxuejiancha（B chaohe CT pingsao）jigangonghe LDH。mei 6 geyue 1 cidapinggu，baokuoguchuanheliuzaopinggu：xiangguan B chao、zengqiang CT jianchahuo MR、mianyigongneng、gangonghe LDH deng。（san）tingyaodi 3 nianyihoumeibannianpinggu 1 ci，zhuyaozuoguchuanheliuzaodeyingxiangxue（B chaoheCT pingsao）jigangonghe LDH。shiqingkuangjiazuoneifenmijisujizhishangdengjiancha。jiu、zhuanzhentiaojian（yi）dangdiyiyuanmeiyouzhenliaotiaojian、meiyouzhiliaojingyandexujiangbingrenzhuanzhenzhiyouzhiliaotiaojiandeshangjiyiyuanyibaozhengliaoxiao。（er）juyougaozhongliufuhehuozhongliuhebingzhengdeweizhongbingrenxuzhuanzhenzhiyoujingyandeshangjiyiyuanyiwanjiushengming。（san）jingshangjiyiyuanzhiliaohouwending、dadaowanquanhuanjiedebingrenkezhuanzhenzhiyouzhiliaotiaojiandexiayijiyiyuanjixuzhiliao，liruweichizhiliaodebingren。qijianjianyidingqihuishangjiyiyuanjinxingliuzaopinggu。ruweichiqijianfashengyanzhongdehebingzheng，ruyanzhongganran，kezhuanhuishangjiyiyuanjinxingqiangjiu。fu ertonglinbamuxibaolinbaliuzhenliaoguifan（2019 nianban）bianxieshendingzhuanjiazu（anxingshibihuapaixu）zuchang：wangtianyouchengyuan：wangtianyou、sunxiaofei、zhangyonghong、tangjingyan、jinling、yangzuo、duanyanlong、zhouchunju、gaozifen、dixiaowenzhegedongxiqishigenbanbendiedaiyouguanxi，nikanzhiqiangongyegeming，qiansancidegongyegeming，gaibianliaoyitudiweijiuyoumoshidezichanmoshi。shuinengbayigedongxifuzhihua，biaozhunhua，liushuihua，shuijiunadaoliaoshidaidekuizeng。houmianyoujingliliaohulianwangdeshidai，youdiedailiaoyiboxindecaifufangshi。nikanhenduolaoyibeideren，tamendejingyingmoshihuanzaikaolaoyitaodefangshizaichulizhexiedongxi。yushitamenbeidiedailiao。
夫(贵耻)唱(颁丑补苍驳)妇(贵耻)随(厂耻颈)
事实上，不止东方甄选，超级头部主播和直播机构的“出走”都会面临平台方的压力。2023年5月1日，石丕民和太太在西藏阿里札达霞义沟摄影创作站长工具 - 91 免费国产永久入口-91中文字幕-人人视频...
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