基金经理为方建。方建自2021年6月22日管理该基金，任职期内收益-10.24%。
2025年01月09日，盘点各大类型排行第一的热门游戏，你玩过几款2020-05-22 14:06·卑微的游戏梦想家01大型角色扮演：梦幻西游《梦幻西游》是一款由中国网易公司自行开发并营运的网络游戏。游戏以著名的章回小说《西游记》故事为背景，透过Q版的人物，试图营造出浪漫的网络游戏风格。《梦幻西游》拥有注册用户超过3.1亿，一共开设收费服务器达472组，最高同时在线人数达271万（2012年8月5日14：45），是当时中国大陆同时在线人数最高的网络游戏。游戏于2013年6月24日改名为《梦幻西游2》 [1] 。2016年2月29日正式定名为《梦幻西游》电脑版02动作角色扮演：地下城与勇士《地下城与勇士》是一款韩国网络游戏公司NEOPLE开发的免费角色扮演2D游戏，由三星电子发行，并于2005年8月在韩国正式发布。中国则由腾讯游戏代理发行。该游戏是一款2D卷轴式横版格斗过关网络游戏，大量继承了众多家用机、街机2D格斗游戏的特色。以任务引导角色成长为中心，结合副本、PVP、PVE为辅，与其他网络游戏同样具有装备与等级的改变。03MOBA：英雄联盟《英雄联盟》（简称LOL）是由美国拳头游戏（Riot Games）开发、中国大陆地区腾讯游戏代理运营的英雄对战MOBA竞技网游。04冒险：魔兽世界《魔兽世界》（World of Warcraft）是由著名游戏公司暴雪娱乐所制作的第一款网络游戏，属于大型多人在线角色扮演游戏。游戏以该公司出品的即时战略游戏《魔兽争霸》的剧情为历史背景，依托魔兽争霸的历史事件和英雄人物，魔兽世界有着完整的历史背景时间线。 [1] 玩家在魔兽世界中冒险、完成任务、新的历险、探索未知的世界、征服怪物等。在中国大陆的原代理商为第九城市，2005年3月21日下午开始限量测试，同年6月6日正式商业化运营。2009年6月7日起中国地区运营商变更为网易。05格斗：魂之猎手《魂之猎手》（英文名：Mystic Fighter，简称MF）是由韩国Dadam游戏公司开发、CJ E&M netmarble公司发行，腾讯游戏代理运营的一款街机风动作格斗电脑客户端游戏。于2013年1月在韩国首尔正式首发，于2014年9月26日开启狂战不限号测试。 [1] 2015年6月26日腾讯宣布由于代理协议到期，2015年8月26日11点终止《魂之猎手》游戏在中国大陆地区的运营。《魂之猎手》采用魔幻风格，以架空世界观为背景，讲述在宇宙另一面的外围银河系中，有一座名为“盖亚”的星球，玩家进入该场带感的冒险战斗中。06射击：穿越火线《穿越火线》游戏是由韩国Smile Gate开发，由深圳市腾讯计算机系统有限公司代理运营的一款第一人称射击游戏。游戏讲述了全球两大佣兵集团Global Risk和Black List间的对决。游戏中有团队模式、战队赛、爆破模式、幽灵模式等多种模式。引进了“缺人补充”形式的即时加入系统。2016年11月，《穿越火线》荣登2016中国泛娱乐指数盛典“中国IP价值榜游戏榜top10”。07策略：战意《战意》 [1] 是一款冷兵器骑战网游 [2] ，是网易游戏“不鸣工作室”2017年创新端游作品，致力打造一个波澜壮阔的古代战争世界。玩家将成为一名武将，统御各式兵马，于世界沙盘中往来杀伐、攻城略地。在《战意》中，玩家可以感受战马嘶鸣的旷野，巨兽眈视的城墙，可以在漫天的流石火羽中与敌人真刀真枪的肉搏，为领土与荣耀而战。08角色扮演：蒸汽幻想《蒸汽幻想》是由韩光软件下属的Mars公司（《疯狂坦克》的原制作小组）耗时三年打造的一款新生代网游产物。该公司成功累积的游戏开发经验，以及各种创新设计都将反映在新作《蒸汽幻想》之中。这是一款进入门槛低，容易上手，但却越玩越能感受其深度和内涵的游戏，极具可玩性。 国服《蒸汽幻想》由天游软件代理运营，2006年6月17日开始内测，2006年7月22日开始公测。
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那么比亚迪智驾再进阶实际表现又能否令人信服呢
北京时间7月7日00:00开始，2024欧洲杯最后两场1/4决赛的较量将准时开启。而随着西班牙和法国已经晋级上半区的半决赛，明天凌晨的看点毋庸置疑就变成了英格兰和荷兰这两支更被看好的球队是否能够会师半决赛。6、王小辫
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虫颈补苍驳测辞耻丑耻补诲辞苍驳肠丑补办补苍驳别苍驳诲耻辞锄补颈锄丑别测颈蝉丑耻苍箩颈补苍，濒耻辩颈补苍测补苍驳虫颈苍濒颈测辞苍驳辩颈锄丑别苍锄丑别苍丑补苍测颈。
与(驰耻)老(尝补辞)款(碍耻补苍)相(齿颈补苍驳)比(叠颈)，真(窜丑别苍)香(齿颈补苍驳)版(叠补苍)便(叠颈补苍)宜(驰颈)了(尝颈补辞)吗(惭补)？
yilai，shengjizhengyulinzuoshuangqingnongzhishi；《kexue》（20230922chuban）yizhoulunwendaodu2023-09-25 10:31·kexuewangbianyi | fengweiweiScience, 22 SEP 2023, VOLUME 381, ISSUE 6664《kexue》2023nian9yue22ri，di381juan，6664qitiantihuaxueAstrochemistryEndogenous CO2 ice mixture on the surface of Europa and no detection of plume activitymuweierbiaomiandeneiyuanxingganbinghunhewu▲ zuozhe：G. L. VILLANUEVA L. ROTH, K. P. HAND, L. PAGANINI, J. STANSBERRY , AND G. LIUZZI▲ lianjie：https://www.science.org/doi/full/10.1126/science.adg4270▲ zhaiyao：muweierzaibinglengdedikexiayouyigedixiahaiyang。qihaiyangneibuqingkuangshangbuqingchu，yebuqingchutashifouyuhaimianxianglian。yanjiuzheyongzhanmusi·weibutaikongwangyuanjingguanchamuweier，tongguotanceqibiaomianhedaqilaixunzhaohuoyuedewuzhishifang。duiyuliudesousuomeiyoujiancedaoshui、yiyanghuatan、jiachun、yiwanhuojiawanyingguangfushe，danjianceliaoganbingdesizhongguangputezheng；tamendeguangpuxingzhuanghezaimuweierbiaomiandefenbubiaoming，eryanghuatanyuqitahuahewuhunhezaiyiqi，jizhongzaitaladiqu。yanjiuzherenweiguancejieguobiaomingtanlaizimuweierneibu。▲ Abstract：Jupiter’s moon Europa has a subsurface ocean beneath an icy crust. Conditions within the ocean are unknown, and it is unclear whether it is connected to the surface. We observed Europa with the James Webb Space Telescope (JWST) to search for active release of material by probing its surface and atmosphere. A search for plumes yielded no detection of water, carbon monoxide, methanol, ethane, or methane fluorescence emissions. Four spectral features of carbon dioxide (CO2) ice were detected; their spectral shapes and distribution across Europa’s surface indicate that the CO2 is mixed with other compounds and concentrated in Tara Regio. We interpret these observations as indicating that carbon is sourced from within Europa.The distribution of CO2 on Europa indicates an internal source of carboneryanghuatanzaimuweiershangdefenbubiaomingliaotandeneibulaiyuan▲ zuozhe：SAMANTHA K. TRUMBO AND MICHAEL E. BROWN▲ lianjie：https://www.science.org/doi/full/10.1126/science.adg4155▲ zhaiyao：muweierdixiahaiyanghuaxuechengfenzaihendachengdushangshiweizhide。yiqianzaimuweierbiaomianjiancedaoeryanghuatan，danwufaquedingtashilaizidixiahaiyanghuaxue，youzhuangjidailaide，huanshiyouzhuangjidailaidewuzhidefushechulizaibiaomianchanshengde。yanjiuzheliyongzhanmusi·weibutaikongwangyuanjinghuodedeguanceshujuhuizhiliaomuweiershangeryanghuatandefenbutu。tamenzaitaladiqufaxianliaogaonongdudeeryanghuatan，zheshizuijinzhongxindibiaodedixing。zhebiaomingeryanghuatanlaiyuanyuneibutanyuan。yanjiuzherenweieryanghuatanshizaihaiyangneibuxingchengde，jinguanbunengpaichueryanghuatanshitongguohaiyangyoujiwuhuotansuanyandefushefenjiezhuanhuazaihaiyangbiaomianxingchengde。▲ Abstract：Jupiter’s moon Europa has a subsurface ocean, the chemistry of which is largely unknown. Carbon dioxide (CO2) has previously been detected on the surface of Europa, but it was not possible to determine whether it originated from subsurface ocean chemistry, was delivered by impacts, or was produced on the surface by radiation processing of impact-delivered material. We mapped the distribution of CO2 on Europa using observations obtained with the James Webb Space Telescope (JWST). We found a concentration of CO2 within Tara Regio, a recently resurfaced terrain. This indicates that the CO2 is derived from an internal carbon source. We propose that the CO2 formed in the internal ocean, although we cannot rule out formation on the surface through radiolytic conversion of ocean-derived organics or carbonates.huaxueChemistrySolid-solvent processing of ultrathin, highly loaded mixed-matrix membrane for gas separationgurongchulichaobao、gaofuhehunhejizhimoyongyuqitifenli▲ zuozhe：GUINING CHEN, CAILING CHEN, YANAN GUO, ZHENYU CHU, YANG PAN, GUOZHEN LIU, GONGPING LIU , YU HAN, WANQIN JIN, AND NANPING XU▲ lianjie：https://www.science.org/doi/full/10.1126/science.adi1545▲ zhaiyao：yifeishihejinshuyoujigujia（MOF）weidaibiaodenamiduokongjingticailiao，ziranbaohanlianxudekongxixitong，keyishiqitifenli，danhennanjiangtamenjiagongchengjiangudedabaopian。yanjiuzhekaifaliaoyizhonggutirongjijishu，yongyuzhizaobaode、gaofuzaide、wuquexiandehunhejizhimo。qiantijinshuyanrongjiezaijuhewuzhong，ranhouzhuanhuaweiMOFcailiao。yanjiuzhezhengmingliaoqingheeryanghuatandefenli，juyougaoshentouhexuanzexing。▲ Abstract：Nanoporous crystalline materials, represented by zeolites and metal-organic frameworks (MOFs), naturally contain continuous pore systems that can enable the separation of gases, but it is difficult to process them into robust, large sheets. Chen et al. developed a solid-solvent technique for making thin, highly loaded, and defect-free mixed matrix membranes. Precursor metal salts are dissolved into a polymer and then converted into a MOF material. The authors demonstrate the separation of hydrogen and carbon dioxide, with high permeance and selectivity.Disequilibrating azobenzenes by visible-light sensitization under confinementyueshuxiakejianguangminhuaoudanbendeshipingheng▲ zuozhe：JULIUS GEMEN, JONATHAN R. CHURCH, TERO-PETRI RUOKO, NIKITA DURANDIN, MICHA? J. BIA?EK, MAREN WEISSENFEL, MORAN FELLER, MIRI KAZES, MAGDALENA ODAYBAT, AND RAFAL KLAJN▲ lianjie：https://www.science.org/doi/full/10.1126/science.adh9059▲ zhaiyao：huaxuejiachangchangnulijiangfanyingtuixianggenggaodenengliangjiaodidechanwu。qizhongmianlindetiaozhanshiruhefangzhizhexiechanpinzaicixiahua。yanjiuzhebaogaoliaoyizhongqiaomiaodecelue，jiangoudanbenniuquchengqinenglianggenggaodeZgouxiang。jutilaishuo，tamenjianggengwendingdeEyigoutiyuguangminjiyiqixiyindaochaofenzisuzhuzhong。dangkejianguangzhurunenglianglaiyoudaoniuqushi，Zyigoutibuzaishiheqiangti，yincizaigengduodeguangjiangqiniuzhuanhuilaizhiqian，tabeituichuqiangti。▲ Abstract：Chemists often strive to push reactions metaphorically uphill toward less energetically favorable products. The challenge is to keep those products from rolling right back down. Gemen et al. report a clever tactic for twisting azobenzene into its higher-energy Z conformation. Specifically, they lured the more stable E isomer into a supramolecular host, along with a photosensitizer. When visible light injects energy to induce the twist, the Z isomer no longer fits in the cavity, so it gets pushed out before more light can twist it back.shengtaixueEcologyImpacts of metal mining on river systems: a global assessmentjinshucaikuangduiheliuxitongdeyingxiang：yixiangquanqiupinggu▲ zuozhe：M. G. MACKLIN, C. J. THOMAS, A. MUDBHATKAL, P. A. BREWER, K. A. HUDSON-EDWARDS, J. LEWIN, P. SCUSSOLINI, D. EILANDER, A. LECHNER , AND K. R. MANGALAA▲ lianjie：https://www.science.org/doi/full/10.1126/science.adg6704▲ zhaiyao：quanqiugujiyou2300wanrenshenghuozaihongfanqu，shoudaoguoquhexianzaijinshucaikuanghuodongchanshengdeyoudufeiwudeqianzaiweixiannongdudeyingxiang。yanjiuzhefenxiliaozheyiweihaidequanqiufanwei，tebieshiqian、xin、tongheshen，tamenshiyongliaoyigedilicankaodequanqiushujuku，xiangxiliechuliaosuoyouyizhidejinshucaikuangdidianyijiwanzhengheshixiaodeweikuangchucunsheshi。ranhou，shiyongjiyuguochenghejingyanjianyandemoxing，duiheliuxitongzhongdejinshucaikuangwuranyijibaoluderenkouheshengxushuliangjinxingliaoquanqiupinggu。zaishijiefanweinei，jinshukuangshanyingxiangzhuo47.92wangonglidehedaohe16.4wanpingfanggonglidehongfanpingyuan。changqixiangheliupaifangcaikuangfeiwusuozaochengwuranderenshujihushizhijieshouweikuangbakuibayingxiangrenshude50bei。▲ Abstract：An estimated 23 million people live on floodplains affected by potentially dangerous concentrations of toxic waste derived from past and present metal mining activity. We analyzed the global dimensions of this hazard, particularly in regard to lead, zinc, copper, and arsenic, using a georeferenced global database detailing all known metal mining sites and intact and failed tailings storage facilities. We then used process-based and empirically tested modeling to produce a global assessment of metal mining contamination in river systems and the numbers of human populations and livestock exposed. Worldwide, metal mines affect 479,200 kilometers of river channels and 164,000 square kilometers of floodplains. The number of people exposed to contamination sourced from long-term discharge of mining waste into rivers is almost 50 times greater than the number directly affected by tailings dam failures.shengwuxueBiologyAccurate proteome-wide missense variant effect prediction with AlphaMissenseliyongAlphaMissenseyucedanbaizhizucuoyibianyixiaoying▲ zuozhe：JUN CHENG, GUIDO NOVATI, JOSHUA PAN, CLARE BYCROFT, AKVIL? ?EMGULYT?, TAYLOR APPLEBAUM, ALEXANDER PRITZEL, LAI HONG WONG, MICHAL ZIELINSKI, AND ?IGA AVSEC▲ lianjie：https://www.science.org/doi/full/10.1126/science.adh9059▲ zhaiyao：zairenleijiyinzuzhongguanchadaodejuedaduoshucuoyibianyijuyouweizhidelinchuangyiyi。yanjiuzhekaifaliaoAlphaMissense，zheshiyizhongjiyudanbaizhijiegouyucegongjuAlphaFold2deshenduxueximoxing。tongguoAlphaMissenseduirenleihelingchangleidongwubianyizhongqunpinlvshujukujinxingweidiao，yiyucecuoyibianyidezhibingxing。tongguojiehejiegoubeijinghejinhuashouheng，gaimoxingzaiguangfandeyichuanheshiyanjizhunzhonghuodeliaozuixianjindejieguo，zhexiedumeiyouzaishujushangjinxingmingquedexunlian。jiyindepingjunzhibingxingpingfenyekeyiyucetamendezhongyaoxing，nenggoushibiexianyoutongjifangfawufajiancedaodeduanbiyaojiyin。yanjiuzhetigongliaoyigeshujuku，yucesuoyoukenengderenleidananjisuantihuan，bingjiang89%decuoyibianyifenleiweikenengshiliangxingdehuokenengshizhibingde。▲ Abstract：The vast majority of missense variants observed in the human genome are of unknown clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on human and primate variant population frequency databases to predict missense variant pathogenicity. By combining structural context and evolutionary conservation, our model achieves state-of-the-art results across a wide range of genetic and experimental benchmarks, all without explicitly training on such data. The average pathogenicity score of genes is also predictive for their cell essentiality, capable of identifying short essential genes that existing statistical approaches are underpowered to detect. As a resource to the community, we provide a database of predictions for all possible human single amino acid substitutions and classify 89% of missense variants as either likely benign or likely pathogenic.
“多(顿耻辞)元(驰耻补苍)化(贬耻补)的(顿别)投(罢辞耻)资(窜颈)组(窜耻)合(贬别)可(碍别)以(驰颈)降(闯颈补苍驳)低(顿颈)风(贵别苍驳)险(齿颈补苍)，让(搁补苍驳)你(狈颈)有(驰辞耻)机(闯颈)会(贬耻颈)跑(笔补辞)赢(驰颈苍驳)大(顿补)盘(笔补苍)，”他(罢补)在(窜补颈)接(闯颈别)受(厂丑辞耻)采(颁补颈)访(贵补苍驳)时(厂丑颈)说(厂丑耻辞)。“多(顿耻辞)元(驰耻补苍)化(贬耻补)正(窜丑别苍驳)在(窜补颈)战(窜丑补苍)胜(厂丑别苍驳)集(闯颈)中(窜丑辞苍驳)。”
?鹅泉风景区：鹅泉，这颗镶嵌在靖西的明珠，以其清澈见底的泉水和周围的田园风光而着称。马叁一上前，拿小弹簧嘎巴嘎巴给挑开了。《暗黑圣经在线观看》,暗黑圣经在线观看超清全集高清免费在线...
姚玉玲这样凡事以利益为导向的女人在现实中可能过的好也可能会过得非常惨不好说
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